Protein Alignment CD2AP and Cd2ap

DIOPT Version :10

• Sequence 1: NP_036252.1
• Gene: CD2AP / 23607
• HGNCID: 14258
• Length: 639
• Species: Homo sapiens
• Sequence 2: NP_033977.3
• Gene: Cd2ap / 12488
• MGIID: 1330281
• Length: 637
• Species: Mus musculus
• Alignment Length: 639
• Identity: 551/639 - (86%)
• Similarity: 577/639 - (90%)
• Gaps: 2/639 - (0%)

Human     1 MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKD 65
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||
Mouse     1 MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEPKD 65

Human    66 DSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDELELK 130
            |:|||||||.|||||||||||||||||||||||||||.||||||||||||||:|.|||||||||.
Mouse    66 DNLPIKRERQGNVASLVQRISTYGLPAGGIQPHPQTKAIKKKTKKRQCKVLFDYSPQNEDELELI 130

Human   131 VGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPTSPIPSLG 195
            |||:||:.||||||||||||||||||||||||||||.|:|||||.||::||..|.|||||:||.|
Mouse   131 VGDVIDVIEEVEEGWWSGTLNNKLGLFPSNFVKELESTEDGETHNAQEESEVPLTGPTSPLPSPG 195

Human   196 NVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVEIT 260
            |.||.|.|||.||||||||||||||||||||||||||||||||||.|||||||.||.:||:||:|
Mouse   196 NGSEPAPGSVAQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKTEKPLILQPLGSRTQNVEVT 260

Human   261 KTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFA 325
            |.|.:|||||||||||||.|.|||||||||:||||||||||||||||||:|||||||||||||||
Mouse   261 KPDVDGKIKAKEYCRTLFPYTGTNEDELTFREGEIIHLISKETGEAGWWKGELNGKEGVFPDNFA 325

Human   326 VQINELDKDFPKPKKPPPPAKAPAPKPELIAAEKKYFSLKPEEKDEKSTLEQKPSKPAAPQVPPK 390
            |||:|||||||||||||||||.|||||:|.|||||.|.||.|||||||.||||||||||||||||
Mouse   326 VQISELDKDFPKPKKPPPPAKGPAPKPDLSAAEKKAFPLKAEEKDEKSLLEQKPSKPAAPQVPPK 390

Human   391 KPTPPTKASNLLRSSGTVYPKRPEKPVPPPPPIAKINGEVSSISSKFETEPVSKLKLDSEQLPLR 455
            |||.||||||||||.|.|||||||||||||||.||||||||.||||.:||||||.|||.||||:|
Mouse   391 KPTAPTKASNLLRSPGAVYPKRPEKPVPPPPPAAKINGEVSIISSKIDTEPVSKPKLDPEQLPVR 455

Human   456 PKSVDFDSLTVRTSKETDVVNFDDIASSENLLHLTANRPKMPGRRLPGRFNGGHSPTHSPEKILK 520
            |||||.|:...|.|||||.||||||||||||||||||||||||||||||||||||||.||||.||
Mouse   456 PKSVDLDAFVARNSKETDDVNFDDIASSENLLHLTANRPKMPGRRLPGRFNGGHSPTQSPEKTLK 520

Human   521 LPKEEDSANLKPSELKKDTCYSPKPSVYLSTPSSASKANTTAFLTPLEIKAKVETDDVKKNSLDE 585
            ||||:||.||||.|.|||..||.|.|  |||||||||.||.|||||||:|||.|.||.|:||:||
Mouse   521 LPKEDDSGNLKPLEFKKDASYSSKSS--LSTPSSASKVNTAAFLTPLELKAKAEADDGKRNSVDE 583

Human   586 LRAQIIELLCIVEALKKDHGKELEKLRKDLEEEKTMRSNLEMEIEKLKKAVLSS 639
            ||||||||||||:|||||||||||||||:|||||.||||||:||.|||||||.|
Mouse   584 LRAQIIELLCIVDALKKDHGKELEKLRKELEEEKAMRSNLEVEIAKLKKAVLLS 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CD2AP	NP_036252.1	Interaction with ANLN and localization to the midbody. /evidence=ECO:0000269|PubMed:15800069	1..175		161/173 (93%)
		SH3_CD2AP_1	3..58	CDD:212986	54/54 (100%)
		SH3_CD2AP_2	111..165	CDD:212987	47/53 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	168..209		27/40 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	227..256		24/28 (86%)
		SH3_CD2AP_3	271..327	CDD:212989	51/55 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	333..428		83/94 (88%)
		SH3-binding. /evidence=ECO:0000255	336..352		14/15 (93%)
		SH3-binding. /evidence=ECO:0000255	378..397		17/18 (94%)
		SH3-binding. /evidence=ECO:0000255	410..422		11/11 (100%)
Cd2ap	NP_033977.3	Interaction with ANLN and localization to the midbody. /evidence=ECO:0000250	1..175		161/173 (93%)
		SH3_CD2AP_1	3..58	CDD:212986	54/54 (100%)
		SH3_CD2AP_2	111..165	CDD:212987	47/53 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	166..209		28/42 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	226..254		24/27 (89%)
		SH3_CD2AP_3	271..327	CDD:212989	51/55 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	333..455		105/121 (87%)
		SH3-binding. /evidence=ECO:0000255	336..352		14/15 (93%)
		SH3-binding. /evidence=ECO:0000255	378..397		17/18 (94%)
		SH3-binding. /evidence=ECO:0000255	410..422		11/11 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	488..555		56/68 (82%)