Protein Alignment DAPK2 and CASK

DIOPT Version :9

• Sequence 1: NP_001350659.1
• Gene: DAPK2 / 23604
• HGNCID: 2675
• Length: 488
• Species: Homo sapiens
• Sequence 2: NP_001262811.1
• Gene: CASK / 42567
• FlyBaseID: FBgn0013759
• Length: 929
• Species: Drosophila melanogaster
• Alignment Length: 528
• Identity: 126/528 - (23%)
• Similarity: 226/528 - (42%)
• Gaps: 113/528 - (21%)

Human    20 EDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHH 84
            :|.|::.|.:|.|.|:||::|..:.:..::|.|.:...:..|| .|:|..:::||.:|...:.|.
  Fly     9 DDVYELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTAS-PGLSTADLKREATICHMLKHP 72

Human    85 NVITLHDVYENRTDVVLILELVSGGEL-FDFLAQKES---LSEEEATSFIKQILDGVNYLHTKKI 145
            :::.|.:.|.:...:.::.|.:.|.:| |:.:.:..:   .||..|..:::|||:.:.|.|...|
  Fly    73 HIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQILEALRYCHENDI 137

Human   146 AHFDLKPENIML--LDKNIPIPHIKLIDFGLAHEI---EDGVEFKNIFGTPEFVAPEIVNYEPLG 205
            .|.|::|...:|  :|.:.|   :||..||.|.::   .:.:|.....|.|.::|||:|.....|
  Fly   138 LHRDVRPACALLATVDNSAP---VKLGGFGSAIQLPGTRETIETHGRVGCPHYMAPEVVTRRLYG 199

Human   206 LEADMWSIGVITYILLSGASPFLGD--TKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVK 268
            ...|:|..||:.::||||..||||.  ..|:::|. ..:|::..|  :...|..|||.:.|:|..
  Fly   200 KGCDVWGAGVMLHVLLSGRLPFLGSGVRLQQSVAR-GRLSFEAPE--WKSISANAKDLVMKMLAA 261

Human   269 ETRKRLTIQEALRHPWITSKGEGRAPEQRKTEPTQL--KTKHLREYTLK---------------- 315
            ....||:|.|.|.||||.        ::.|.:.|.|  ..:.|:.|..:
  Fly   262 NPHHRLSITEVLDHPWIR--------DRDKLQRTHLADTVEELKRYNARRKLKGAVQAIAGGTNM 318

Human   316 -----CHSSMPPNNSYVNFERFACVVEDVARVDLGC----RALVEAH-------DTIQDD-VEAL 363
                 ..:.||...:...:......:|.|.|: |.|    .:|.:||       |.::|: :...
  Fly   319 DPLYATDADMPITGATDEWADEEAGIEAVQRI-LDCLDDIYSLQDAHVDADVLRDMLRDNRLHQF 382

Human   364 VSIFNEKEAWYREENESA---------RHDLSQLRY---------EFRKVESLKKLLREDIQATG 410
            :.:|:...|.....|..|         |..|.||..         ::.|.|.::.|....:||..
  Fly   383 LQLFDRIAATVVTSNGRAPAAEAVGRCRDVLEQLSSTSGGNSLGGKYAKEELMRLLAAPHMQALL 447

Human   411 CSLGSMAR----------------------KLDHLQAQFEILRQELSADLQWIQELVGSFQLESG 453
            .|...:||                      :||:::          ..:||.:.. |...|.:..
  Fly   448 HSHDVVARDVYGEEALRVTPPPMVPYLNGDELDNVE----------GGELQHVTR-VRLVQFQKN 501

Human   454 SSEGLGST 461
            :.|.:|.|
  Fly   502 TDEPMGIT 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAPK2	NP_001350659.1	STKc_DAPK2	17..285	CDD:271098	82/275 (30%)
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	89/313 (28%)
		S_TKc	12..278	CDD:214567	81/272 (30%)
		L27	347..396	CDD:280918	11/49 (22%)
		L27	406..462	CDD:280918	12/55 (22%)
		PDZ_signaling	493..573	CDD:238492	5/17 (29%)
		SH3_CASK	586..646	CDD:213014
		Guanylate_kin	710..883	CDD:279019
		GuKc	720..883	CDD:214504

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910