DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PATZ1 and Kr-h1

DIOPT Version :9

Sequence 1:	NP_055138.2	Gene:	PATZ1 / 23598	HGNCID:	13071	Length:	687	Species:	Homo sapiens
Sequence 2:	NP_477466.1	Gene:	Kr-h1 / 33861	FlyBaseID:	FBgn0266450	Length:	845	Species:	Drosophila melanogaster

Alignment Length:	461	Identity:	115/461 - (24%)
Similarity:	172/461 - (37%)	Gaps:	83/461 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   247 LTSPFPSVASSAPPLTGKRGRGRPRKANLLDSMFGSPGGLREAGILPCGLCGKVFTDANRLRQHE 311
            :|:..|:.|.||..:..:...|.|..|.:: |....|...:..  ..|..||..|...:....|.
  Fly   152 ITNAAPTAAPSAQRIKTEPVGGFPASAAVV-SQVRKPSASKPQ--FKCDQCGMTFGSKSAHTSHT 213

Human   312 AQH--------------GVTSLQLGYIDLPPPRLGENGLPISEDPDGPRKRSRTRKQVA------ 356
            ..|              ||.:    .:......|.:.|||:. .|..|     |.|.:|
  Fly   214 KSHSKNQDLSLNGASGAGVAA----PVSTAAIELNDAGLPVG-IPKSP-----TIKPLANVAAGA 268

Human   357 ----CEICGKIFRDVYHLNRHKLSHSGEKPYSCPVCGLRFKRKDRMSYHVRSHDGSVGKPYICQS 417
                |.:|.|.|.....|.||..:|:||:|:.|..|...|..|:.:..|.|.|  :..:||.|..
  Fly   269 DPYQCNVCQKTFAVPARLIRHYRTHTGERPFECEFCHKLFSVKENLQVHRRIH--TKERPYKCDV 331

Human   418 CGKGFSRPDHLNGHIKQVHTSERPHKCQTCNASFATRDRLRSHLACHEDKVPCQV----CGK-YL 477
            ||:.|.....|:.|:: :||.||||||..|..:|....:|..|:..|..:.|.:.    ||| :.
  Fly   332 CGRAFEHSGKLHRHMR-IHTGERPHKCSVCEKTFIQSGQLVIHMRTHTGEKPYKCPEPGCGKGFT 395

Human   478 RAAYMADHLKKHSEGPSNFCSICNRGFSSASYLKVHVKTHHGVPLPQVSRHQEPILNGGAAFHCA 542
            .:..:..|.:.|:......|.||.|.|.....||:|...|:|      |:..:..:       |.
  Fly   396 CSKQLKVHSRTHTGEKPYHCDICFRDFGYNHVLKLHRVQHYG------SKCYKCTI-------CD 447

Human   543 RTYGNKEGQKC---SHQDPIESSDSYGDLSDASDLKTPEKQSANGSFSCDMAVPKNKMESDGEKK 604
            .|:.||:..:.   .|.:  |..|...:.:.||...:....|:.||.|. ..|..|. ||.....
  Fly   448 ETFKNKKEMEAHIKGHAN--EVPDDEAEAAAASAAASTSAGSSAGSPSL-QGVSSNS-ESSNHSP 508

Human   605 YPCPECGSFFRSKSYLNKHIQKVHVRALGGPLGDLGPALGSPFSPQQNMSLLESFGFQIVQSAFA 669
            ...|....  :.:......:.|.....|..|       ..||.||.   ||..::      |..|
  Fly   509 PSSPPATK--KPRQARQPRVSKTVAATLSIP-------TSSPLSPS---SLSSTY------SPSA 555

Human   670 SSLVDP 675
            ||:..|
  Fly   556 SSMASP 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PATZ1	NP_055138.2	BTB_POZ_ZBTB19_PATZ1	14..162	CDD:349516
		A-T hook domain	264..272		2/7 (29%)
		Zn finger DNA binding domain	294..628		92/365 (25%)
		C2H2 Zn finger	294..314	CDD:275368	5/19 (26%)
		C2H2 Zn finger	357..377	CDD:275368	7/19 (37%)
		zf-C2H2	357..377	CDD:395048	7/19 (37%)
		COG5048	<381..518	CDD:227381	43/141 (30%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
		C2H2 Zn finger	415..433	CDD:275368	6/17 (35%)
		C2H2 Zn finger	444..464	CDD:275368	5/19 (26%)
		C2H2 Zn finger	497..517	CDD:275368	8/19 (42%)
		zf-C2H2_assoc3	536..604	CDD:406930	17/70 (24%)
		C2H2 Zn finger	607..628	CDD:275370	2/20 (10%)
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	5/19 (26%)
		COG5048	<270..420	CDD:227381	48/152 (32%)
		zf-C2H2	271..293	CDD:278523	7/21 (33%)
		C2H2 Zn finger	273..293	CDD:275368	7/19 (37%)
		zf-H2C2_2	286..309	CDD:290200	9/22 (41%)
		C2H2 Zn finger	301..321	CDD:275368	6/19 (32%)
		zf-H2C2_2	313..338	CDD:290200	9/26 (35%)
		C2H2 Zn finger	329..349	CDD:275368	6/20 (30%)
		zf-H2C2_2	344..366	CDD:290200	11/22 (50%)
		C2H2 Zn finger	357..377	CDD:275368	5/19 (26%)
		zf-H2C2_2	370..396	CDD:290200	7/25 (28%)
		C2H2 Zn finger	385..407	CDD:275368	4/21 (19%)
		zf-H2C2_2	400..424	CDD:290200	7/23 (30%)
		C2H2 Zn finger	415..435	CDD:275368	8/19 (42%)
		zf-C2H2	441..463	CDD:278523	4/28 (14%)
		C2H2 Zn finger	443..463	CDD:275368	4/26 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000