DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VSIG2 and dpr13

DIOPT Version :9

Sequence 1:	NP_055127.2	Gene:	VSIG2 / 23584	HGNCID:	17149	Length:	327	Species:	Homo sapiens
Sequence 2:	NP_001033956.2	Gene:	dpr13 / 3885598	FlyBaseID:	FBgn0034286	Length:	419	Species:	Drosophila melanogaster

Alignment Length:	244	Identity:	51/244 - (20%)
Similarity:	84/244 - (34%)	Gaps:	78/244 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    33 LSTPLGKTAELTCTYSTSVGDSFALEWSFVQPGKPISESHPILYFTNGHLYPTG----SKSKRVS 93
            ::|.:|.||.:.||.. .:|:. .:.|               :...:.||...|    |..:|.|
  Fly   185 VTTQIGATAHVPCTVH-HIGEG-VVSW---------------IRKKDYHLLTVGLTTYSSDERFS 232

Human    94 L--LQNPPTVGVATLKLTDVHPSDTGTYLCQVN-NPPDFYTNGLGLINLTVLV--PPSNPLCSQS 153
            .  |::...   .||::..|...|.|.|.|||: :||......|.::.....:  ||...|
  Fly   233 ATHLKHSED---WTLQIKFVQLRDAGVYECQVSTHPPTSIFLHLSVVEARAEITGPPIRYL---- 290

Human   154 GQTSVGGSTALRCSSSEGAPKPVY----------NW-----VRLGTFPTPSPGSMVQDEVSGQLI 203
               :.|.:..|:|...:......|          |:     :.:.|.|         |..|.:|.
  Fly   291 ---TPGSTLRLQCRVVQNTEASEYIFWYHDNRMINYDIDRGINVSTEP---------DFQSSELT 343

Human   204 LTNLSLTSSGTYRCVATNQMGSASCELTLSVTEPSQGRVAGALIGVLLG 252
            :.......||.:.|||:|             |:|     |..|:.:..|
  Fly   344 IQRTRREHSGNFTCVASN-------------TQP-----ASVLVHIFKG 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VSIG2	NP_055127.2	V-set	31..142	CDD:311561	27/115 (23%)
		Ig	164..231	CDD:319273	15/81 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..327
dpr13	NP_001033956.2	V-set	180..276	CDD:284989	27/110 (25%)
		IG_like	182..262	CDD:214653	23/96 (24%)
		IG_like	285..362	CDD:214653	19/105 (18%)
		IGc2	292..361	CDD:197706	15/77 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910