DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VSIG2 and side-V

DIOPT Version :9

Sequence 1:	NP_055127.2	Gene:	VSIG2 / 23584	HGNCID:	17149	Length:	327	Species:	Homo sapiens
Sequence 2:	NP_611765.2	Gene:	side-V / 37679	FlyBaseID:	FBgn0085400	Length:	1174	Species:	Drosophila melanogaster

Alignment Length:	340	Identity:	77/340 - (22%)
Similarity:	121/340 - (35%)	Gaps:	92/340 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    32 PLSTPLGKTAELTCTYSTSVGDSFALEWSFVQPGKPISES-HPILYFTNGHLYPTGSKSKRVSLL 95
            |.:...|..:|:.    |:||...||....| ||..|.:. ..::::..|::.|..:...|
  Fly    33 PATADEGPLSEIL----TAVGSEVALPCDLV-PGTGIVDKVQLVIWYRQGNVKPIYTFDAR---- 88

Human    96 QNPPTVGV--------------------ATLKLTDVHPSDTGTYLCQVNNPPDFYTNGL--GLIN 138
            ..|..:|:                    ..|::.::..||.|.|.|:|    ||:.:..  ..||
  Fly    89 GRPLNLGIPWADESVFNKKAHFHHDTDPPALRIKNIQTSDAGLYKCRV----DFHKSPTRNWRIN 149

Human   139 LTVLVPPSN-PLCSQSG-----QTS----VGGSTALRCSSSEGAPKPVYNWVRLGTFPTPSPGSM 193
            :||||||:. .:....|     ||:    .|.|..|.|.||.|.|.|..:|.|
  Fly   150 VTVLVPPTALTILDHHGAEIRDQTAGPYLEGDSIDLTCLSSGGVPPPRVSWWR------------ 202

Human   194 VQDEVSGQLILTNLSLTSSGTYRCVATNQMGSASCELTLSVTEPSQGRVAGALIGVLLGVLLLSV 258
                 ...||..:..:...|:.|.|...:.......||:...:.|.|.|..||...::..:.|..
  Fly   203 -----EHALIDDSFQVLPDGSVRNVLRLKNIQRKDLLTMYTCQASNGHVVPALTKKVILDMNLPP 262

Human   259 AAFCLVRFQKERGKKPKETYGGSDLREDAIAPGISEHTCMRAD---------SSKGFLERPSSAS 314
            .:..|                 ..|....||...|..||....         |..|.:.|.:::|
  Fly   263 LSLLL-----------------QGLNHAVIAGTRSHVTCTAIGARPPPEIIWSKAGQIVRGATSS 310

Human   315 TVT---TTKSKLPMV 326
            |.:   ||.|:|.::
  Fly   311 TSSDGNTTISELMLI 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VSIG2	NP_055127.2	V-set	31..142	CDD:311561	29/132 (22%)
		Ig	164..231	CDD:319273	14/66 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..327		8/25 (32%)
side-V	NP_611765.2	Ig	42..153	CDD:299845	27/123 (22%)
		IG_like	42..152	CDD:214653	26/122 (21%)
		IGc2	179..245	CDD:197706	19/82 (23%)
		IG_like	179..245	CDD:214653	19/82 (23%)
		Ig	<282..348	CDD:299845	11/44 (25%)
		IGc2	400..459	CDD:197706
		FN3	719..798	CDD:214495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910