DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VSIG2 and Lac

DIOPT Version :9

Sequence 1:	NP_055127.2	Gene:	VSIG2 / 23584	HGNCID:	17149	Length:	327	Species:	Homo sapiens
Sequence 2:	NP_523713.2	Gene:	Lac / 36363	FlyBaseID:	FBgn0010238	Length:	359	Species:	Drosophila melanogaster

Alignment Length:	188	Identity:	50/188 - (26%)
Similarity:	78/188 - (41%)	Gaps:	24/188 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    37 LGKTAELTCTYSTSVGDSFALEWS--FVQPGKPISESHPILYFTNGHLYPTGSKSKRVSLLQNPP 99
            :|.|.|..|:.      .:|.|::  |::     ::|.|:...|...|.   .|..|.||..:|.
  Fly    42 IGGTVEFDCSV------QYAKEYNVLFLK-----TDSDPVFLSTGSTLV---IKDSRFSLRYDPN 92

Human   100 TVGVATLKLTDVHPSDTGTYLCQVNNPPDFYTNGLGLINLTVLVPP-SNPLCSQSGQTSVGGSTA 163
            : ....|::.|:..:|.|||.|||........:  ..:.|:|..|| .:...:||...|.|....
  Fly    93 S-STYKLQIKDIQETDAGTYTCQVVISTVHKVS--AEVKLSVRRPPVISDNSTQSVVASEGSEVQ 154

Human   164 LRCSSSEGAPKPVYNWVRLGTFPTPSPGSMVQDEVSGQLILTNLSLTSSGTYRCVATN 221
            :.|.:| |.|.|...|.|......|:..:..   |...|.:.::.....|||.|||.|
  Fly   155 MECYAS-GYPTPTITWRRENNAILPTDSATY---VGNTLRIKSVKKEDRGTYYCVADN 208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VSIG2	NP_055127.2	V-set	31..142	CDD:311561	26/106 (25%)
		Ig	164..231	CDD:319273	17/58 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..327
Lac	NP_523713.2	IG_like	36..131	CDD:214653	26/105 (25%)
		FR1	37..50	CDD:409353	3/7 (43%)
		Ig strand A'	37..42	CDD:409353	50/188 (27%)
		Ig strand B	44..51	CDD:409353	2/6 (33%)
		CDR1	51..59	CDD:409353	2/13 (15%)
		Ig strand C	59..63	CDD:409353	0/3 (0%)
		FR2	60..63	CDD:409353	0/2 (0%)
		CDR2	67..81	CDD:409353	4/16 (25%)
		Ig strand C'	68..72	CDD:409353	1/3 (33%)
		Ig strand C'	79..81	CDD:409353	0/4 (0%)
		FR3	84..115	CDD:409353	11/31 (35%)
		Ig strand D	84..90	CDD:409353	3/5 (60%)
		Ig strand E	94..102	CDD:409353	1/7 (14%)
		Ig strand F	108..115	CDD:409353	4/6 (67%)
		CDR3	116..124	CDD:409353	0/7 (0%)
		FR4	124..130	CDD:409353	0/7 (0%)
		Ig strand G	124..130	CDD:409353	0/7 (0%)
		Ig_3	134..208	CDD:404760	22/77 (29%)
		Ig strand B	153..157	CDD:409353	0/3 (0%)
		Ig strand C	166..170	CDD:409353	0/3 (0%)
		Ig strand E	187..191	CDD:409353	1/3 (33%)
		Ig strand F	201..206	CDD:409353	3/4 (75%)
		Ig strand G	215..218	CDD:409353
		Ig	227..318	CDD:416386
		Ig strand C	256..260	CDD:409353
		Ig strand E	286..290	CDD:409353
		Ig strand F	300..305	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910