DRSC/TRiP Functional Genomics Resources

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Protein Alignment VSIG2 and kek2

DIOPT Version :9

Sequence 1:NP_055127.2 Gene:VSIG2 / 23584 HGNCID:17149 Length:327 Species:Homo sapiens
Sequence 2:NP_523551.1 Gene:kek2 / 34582 FlyBaseID:FBgn0015400 Length:894 Species:Drosophila melanogaster


Alignment Length:352 Identity:77/352 - (21%)
Similarity:121/352 - (34%) Gaps:103/352 - (29%)


- Green bases have known domain annotations that are detailed below.


Human    40 TAELT-CTYSTSVGDSFA----LEWSFVQPGKPISESHPILYFTNGHLYPTGSKSKR-VSLLQNP 98
            |.||: |.......::|.    |||..:       :.:.|.:....|:.|   ||.. :||..|.
  Fly   154 TLELSNCQVERIENEAFVGMDNLEWLRL-------DGNRIGFIQGTHILP---KSLHGISLHSNR 208

Human    99 PTVGVATLKLTDVHPSDTGTYLCQVNNP--------PDFYTNGLGLINL----TVLVPPSNPLCS 151
            ..   ...:|.|:|     .:|...|.|        ......|..:.:|    ...:|..:|   
  Fly   209 WN---CDCRLLDIH-----FWLVNYNTPLAEEPKCMEPARLKGQVIKSLQREQLACLPEVSP--- 262

Human   152 QSGQTSV--GGSTALRCSSSEGAPKPVYNWVRLGTFPTPSPGSMVQ--------DE---VSG--- 200
            ||..|.|  |.:.::.| .....|:|...|:..|  ...|..|::.        ||   |||   
  Fly   263 QSSYTEVSEGRNMSITC-LVRAIPEPKVLWLFNG--QVMSNDSLMDNLHMYYYIDETIGVSGAEE 324

Human   201 ---QLILTNLSLTSSGTYRCVATNQMGSASCELTLS--------VTEPSQGR-------VAGALI 247
               ::.:.|:....:||:.||..|..|:.....||.        |.|.|..|       .:.|..
  Fly   325 KRSEIFIYNVGAEDNGTFSCVGQNIAGTTFSNYTLRVIIKEPPVVNEVSFPRDYMNYIVASSAGG 389

Human   248 GVLLGVLLLSVAAFCLVRFQ--KERGKKPKETYGGSDLREDAIAPGISEHTCMRADSSKGFLERP 310
            |::..|||.::...|....:  |:|.|..:.|         :||.|....|....|:..|.::..
  Fly   390 GIIFVVLLCTIVVKCKKTSEPAKQRKKCDQVT---------SIAGGTDSSTGSTQDTGMGMMKCA 445

Human   311 S----------------SASTVTTTKS 321
            |                ...|:|.||:
  Fly   446 SILNDGGDSMNGNPGLLLGDTLTPTKA 472

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VSIG2NP_055127.2 V-set 31..142 CDD:311561 24/119 (20%)
Ig 164..231 CDD:319273 19/83 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 305..327 6/33 (18%)
kek2NP_523551.1 leucine-rich repeat 34..52 CDD:275380
leucine-rich repeat 54..79 CDD:275380
LRR_8 79..138 CDD:290566
LRR_RI <80..187 CDD:238064 8/39 (21%)
leucine-rich repeat 80..103 CDD:275380
leucine-rich repeat 104..127 CDD:275380
LRR_8 126..186 CDD:290566 8/38 (21%)
leucine-rich repeat 128..151 CDD:275380
leucine-rich repeat 152..175 CDD:275380 5/20 (25%)
leucine-rich repeat 176..198 CDD:275380 6/31 (19%)
TPKR_C2 207..256 CDD:301599 9/56 (16%)
I-set 258..361 CDD:254352 28/108 (26%)
Ig_2 263..361 CDD:290606 26/100 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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