DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VSIG2 and dpr18

DIOPT Version :9

Sequence 1:	NP_055127.2	Gene:	VSIG2 / 23584	HGNCID:	17149	Length:	327	Species:	Homo sapiens
Sequence 2:	NP_573102.1	Gene:	dpr18 / 32572	FlyBaseID:	FBgn0030723	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	395	Identity:	85/395 - (21%)
Similarity:	128/395 - (32%)	Gaps:	166/395 - (42%)

- Green bases have known domain annotations that are detailed below.

Human    28 VPTE------PLSTP--------------LGKTAEL-TCTYSTSVGDSFALEWSFV-QP------ 64
            :||:      |:.||              :|.|.:| |.|..|:...|..::.|.: ||
  Fly   125 IPTKMSRGKIPMETPGSMEFSSNSLPIKNVGTTDQLTTVTMPTTAFASLKVDRSTMKQPIDSTRT 189

Human    65 -------------GKPISESH-----------PILYFTNG-------HLYPTGSKSKRVSLLQNP 98
                         .:|.|:.|           ||...|:|       ||:.....:.||.:|::.
  Fly   190 RNHWTASGFARVTERPRSKHHHEHHWGPFFEEPINSATSGDNLVSAVHLFTEAVLNCRVGMLKDK 254

Human    99 P--------------TVGVAT------------------LKLTDVHPSDTGTYLCQVN-NPPDFY 130
            .              |||..|                  |.:......|.|.|:|||: :||..:
  Fly   255 TVMWVRRTAEKVSLLTVGNVTYSGDPRIRVKFQYPNNWRLLINPTQTEDAGVYMCQVSTHPPRVF 319

Human   131 TNGLGLINLTVLVPPSNPLCSQSGQTSVG------GSTA-LRC---------------SSSEGAP 173
            |.     |||||.||...:  ...:..||      |||. |:|               .|::.|.
  Fly   320 TT-----NLTVLEPPLRII--DEHERDVGDRYYKSGSTVDLQCQISRSFFQKERQTILKSTDSAN 377

Human   174 KPVYNWVRLGTFPTPSPGSM--VQDEVSGQ--------------------------LILTNLSLT 210
            ..|...:...|......|::  .|.:.|||                          |.::::.||
  Fly   378 DAVQKLINETTSELNLIGNVNQTQHKFSGQDLEKYFTKFITWAKDEEPLQGMTNRRLSVSDVWLT 442

Human   211 SSGTYRCVATNQMGSASCELTLSVTEPSQ-----GRVAGAL---IG--------VLLGVLLLSVA 259
            |..:......:..|:.||.|....|...|     |.:..|:   ||        .:||.||:.:.
  Fly   443 SRISIGDAKLSDSGNYSCSLGRLFTVIVQVQVLTGELPAAVQHNIGSRTEIYSLAMLGHLLVLIF 507

Human   260 AF-CL 263
            .| ||
  Fly   508 LFTCL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VSIG2	NP_055127.2	V-set	31..142	CDD:311561	42/202 (21%)
		Ig	164..231	CDD:319273	18/109 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..327
dpr18	NP_573102.1	IG_like	242..325	CDD:214653	19/87 (22%)
		Ig	<258..326	CDD:299845	17/72 (24%)
		IGc2	<417..461	CDD:197706	6/43 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910