DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VSIG2 and dpr8

DIOPT Version :9

Sequence 1:	NP_055127.2	Gene:	VSIG2 / 23584	HGNCID:	17149	Length:	327	Species:	Homo sapiens
Sequence 2:	NP_001285239.1	Gene:	dpr8 / 32387	FlyBaseID:	FBgn0052600	Length:	344	Species:	Drosophila melanogaster

Alignment Length:	338	Identity:	61/338 - (18%)
Similarity:	115/338 - (34%)	Gaps:	88/338 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    14 LGFLCLSGLAVE-----------VKVPTEPLSTP-------------LGKTAELTCTYSTSVGDS 54
            ||.|||.....:           ..:||.....|             :|||.:|||... ::|:.
  Fly     9 LGILCLLAGCTDGASKRFFTDFLQDLPTPGTGGPTFDTTIGTNITGLVGKTVKLTCRVK-NLGNR 72

Human    55 FALEWSFVQPGKPISESHPILYFTNGHLYPTG----SKSKRVSLLQNPPTVGVATLKLTDVHPSD 115
             .:.|               :...:.||...|    :..:|...:.:|.... .||::......|
  Fly    73 -TVSW---------------VRHRDIHLLTVGRYTYTSDQRFEAMHSPHAED-WTLRIRYAQRKD 120

Human   116 TGTYLCQVNNPPDFYTNGLGLINLTVLVPPSNPLCSQSGQTSVGGSTALRC-SSSEGAPKPVYNW 179
            :|.|.||::..|....:    :.|.::.|.::.:.......:.|.:..|.| ......|.|...|
  Fly   121 SGIYECQISTTPPIGHS----VYLNIVEPVTDIIGGPELHINRGSTINLTCIVKFAPEPPPTVIW 181

Human   180 V---RLGTFPTPSPG-SMVQDE---VSGQLILTNLSLTSSGTYRCVATN------QMGSASCELT 231
            .   .:..|.:|..| |:|.::   .:.:|::.......||.|.|..:|      ::.....|..
  Fly   182 SHNREIINFDSPRGGISLVTEKGVLTTSRLLVQKAITQDSGLYTCTPSNANPTSVRVHIVDGEHP 246

Human   232 LSVTEPSQGRVAGALIGVLLGVLLLSVAAFCLVR------------------------FQKERGK 272
            .::...:.|....:...|||.::||:.:...|::                        |.:|:..
  Fly   247 AAMHTGNNGNSTASQPPVLLPLVLLTCSTLMLLQLVASCSTLVPATPPGCRTVQQASTFAEEKAM 311

Human   273 KPKETYGGSDLRE 285
            ..:......||:|
  Fly   312 GQRSNRNCQDLQE 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VSIG2	NP_055127.2	V-set	31..142	CDD:311561	23/127 (18%)
		Ig	164..231	CDD:319273	17/80 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..327
dpr8	NP_001285239.1	IG_like	51..131	CDD:214653	20/97 (21%)
		V-set	52..143	CDD:284989	22/112 (20%)
		IG_like	153..238	CDD:214653	17/84 (20%)
		ig	153..232	CDD:278476	17/78 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910