DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VSIG2 and igsf11

DIOPT Version :9

Sequence 1:	NP_055127.2	Gene:	VSIG2 / 23584	HGNCID:	17149	Length:	327	Species:	Homo sapiens
Sequence 2:	NP_001265751.1	Gene:	igsf11 / 100004469	ZFINID:	ZDB-GENE-080303-21	Length:	442	Species:	Danio rerio

Alignment Length:	319	Identity:	102/319 - (31%)
Similarity:	164/319 - (51%)	Gaps:	20/319 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    12 ALLGFLCLS--GLAVEVKVPTEPLSTPLGKTAELTCTYSTSVG-DSFALEWSFVQPGKPISESHP 73
            |.|.|.|::  ..|:||.|....:....|:.|.|.||:|||.. ::..:.| .|.|....::...
Zfish    12 AWLVFFCVNVCVYALEVTVSQSSVQVARGQAAVLPCTFSTSAALNNLYIIW-MVTPLANANQPEQ 75

Human    74 ILYFTNGHLYPTGS-KSKRVSLLQNPPTVGVATLKLTDVHPSDTGTYLCQVNNPPDFYTNGLGLI 137
            ::.:.:|.::...: .:.||..:...|:.. |::.:.:...||||||.|.|||.||.....:|:|
Zfish    76 VIIYQSGQVFSLANHMNGRVGFVSTMPSTS-ASIFINNTQLSDTGTYQCLVNNLPDRGGRNIGVI 139

Human   138 NLTVLVPPSNPLCSQSGQTSVGGSTALRCSSSEGAPKPVYNWVRLGTFPTPSPGSMVQDEVSGQL 202
            .||||||||.|.|...|...||....|.|.|.||.|.|.|.|.:..:.| ..|.:.:||::.|.:
Zfish   140 GLTVLVPPSIPSCRVQGSLDVGSDVMLLCGSDEGIPTPTYAWEKQESVP-KLPHNAMQDQMQGTV 203

Human   203 ILTNLSLTSSGTYRCVATNQMGSASCELTLSVTEP---SQGRVAGALIGVLLGVLLLSVAAFCLV 264
            .|.|:|.::||.|:|.|:|.:|.::|.|.|.||.|   |.|.:||.:...:|.:::.|......:
Zfish   204 TLRNISSSTSGLYQCTASNAIGRSTCVLNLQVTAPQPQSVGLIAGTIATGVLALIICSSLVLVSL 268

Human   265 RFQKERGKKPKETYGGSDLREDAIAPGISEHTCMRADSSKGFLERPSSA--STVTTTKS 321
            .:.:.:.|..:|.. .:::|||.:.|       .|:.|.|.|....||:  .|:|:|.:
Zfish   269 FYWRNKNKYEEEEI-PNEIREDDLPP-------KRSSSVKAFQADASSSENDTLTSTNT 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VSIG2	NP_055127.2	V-set	31..142	CDD:311561	32/112 (29%)
		Ig	164..231	CDD:319273	25/66 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..327		6/19 (32%)
igsf11	NP_001265751.1	V-set	31..144	CDD:284989	32/114 (28%)
		IG_like	32..127	CDD:214653	24/96 (25%)
		IG_like	160..235	CDD:214653	29/75 (39%)
		IGc2	161..225	CDD:197706	24/64 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D841952at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920