Protein Alignment LPAR3 and 5-HT1B

DIOPT Version :9

• Sequence 1: XP_024301895.1
• Gene: LPAR3 / 23566
• HGNCID: 14298
• Length: 364
• Species: Homo sapiens
• Sequence 2: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 602
• Identity: 99/602 - (16%)
• Similarity: 164/602 - (27%)
• Gaps: 284/602 - (47%)

Human    10 STMNECHYDKHMDFFYNRSNTDTVDD---------WTGTKLVIVLCVGTFFCLFIFFSNSLVIAA 65
            |.:::..:::.::...|.:..|.|||         |...|::.:..|.....|.....|..||||
  Fly    50 SNLSQIVWNRSINGNGNSNTFDLVDDEQERAAVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIAA 114

Human    66 VIKNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLD-------SS 123
            :|..|.......||:|:||.||.|...    |:...|.|.:  ..|.|.|...|.|       ..
  Fly   115 IILERNLQNVANYLVASLAVADLFVAC----LVMPLGAVYE--ISNGWILGPELCDIWTSCDVLC 173

Human   124 LTASLTNLLVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACS 188
            .|||:.:|:.||.:|:.::..:..::..|.:||.|:|..||..|:.:...|..||.
  Fly   174 CTASILHLVAIAADRYWTVTNIDYNNLRTPRRVFLMIFCVWFAALIVSLAPQFGWK--------- 229

Human   189 SLAPIYSR-------------SYLVFWTVSNL-MAFLIMVVVYLRIYVYVKR------------- 226
              .|.|.:             .|.:|.|.... :..|:::.:|.:||:..::
  Fly   230 --DPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVT 292

Human   227 -------------------------------KTNVLSPHTSGSISRRR----------------- 243
                                           :|.|....|.|.:.||.
  Fly   293 LTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICFGRNTNTANV 357

Human   244 ----------------------------------------------------------------- 243
                                                                             
  Fly   358 VAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDYRTSNANEII 422

Human   244 ----------------------TPM---------------------------------------- 246
                                  ||:
  Fly   423 TLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSGS 487

Human   247 -------------------------------------------KLMKTVMTVLGAFVVCWTPGLV 268
                                                       |..:|:..:.||||:||.|..|
  Fly   488 GEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFFV 552

Human   269 VLLLDGLNCRQCGVQ-HVKRWFLLLALLNSVVNPIIYSYKDEDMYGTMKKMICCFSQENPERRPS 332
            :.|...| |::|.:. .|...||.|...||.:||:||:..:.:.....|:::  |.::...|  :
  Fly   553 MALTMSL-CKECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRIL--FGRKAAAR--A 612

Human   333 RIPSTVLSRSDTGSQYI 349
            |.........|...||:
  Fly   613 RSAKIXFQLKDNEDQYL 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LPAR3	XP_024301895.1	7tmA_LPAR3_Edg7	42..315	CDD:320465	84/525 (16%)
		TM helix 1	43..69	CDD:320465	8/25 (32%)
		TM helix 2	76..101	CDD:320465	9/24 (38%)
		TM helix 3	113..143	CDD:320465	11/36 (31%)
		TM helix 4	156..174	CDD:320465	6/17 (35%)
		TM helix 5	194..223	CDD:320465	8/42 (19%)
		TM helix 6	243..273	CDD:320465	13/216 (6%)
		TM helix 7	283..308	CDD:320465	10/25 (40%)
5-HT1B	NP_001137708.2	7tm_1	107..>288	CDD:278431	50/197 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910