Protein Alignment PIGN and PIG-N

DIOPT Version :10

• Sequence 1: NP_001425825.1
• Gene: PIGN / 23556
• HGNCID: 8967
• Length: 970
• Species: Homo sapiens
• Sequence 2: NP_610549.1
• Gene: PIG-N / 36049
• FlyBaseID: FBgn0033479
• Length: 894
• Species: Drosophila melanogaster
• Alignment Length: 988
• Identity: 307/988 - (31%)
• Similarity: 486/988 - (49%)
• Gaps: 158/988 - (15%)

Human     3 LFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQ----FTPLPPPARRLVLFVADGLRADALYELD 63
            ::....|::|.:...|||.|||.||::.|:|||    :..|.|||.||||.|.||.|||:.:|
  Fly     1 MWIAYALVVHVLLLGSIFVIYFRSPVITGLTPQKHLLYYGLEPPANRLVLIVTDGFRADSFFE-- 63

Human    64 ENGNSR-APFIRNIIMHEGSWGISHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLF 127
              .|.| .|.:|.|.:.||..|:|.||||||:||||:.||||.|||.|||.:|||.||::||::|
  Fly    64 --ENCRYVPNLRKIFLREGVVGVSRTRVPTETRPGHITLIAGLYEDPSAVLRGWKSNPIDFDTVF 126

Human   128 NESKYTWSWGSPDILPMFAKGASGDHVYT--YSYDAKREDFG-AQDATKLDTWVFDNVKDFFHHA 189
            |.|..|::||:.|:|.:|:..::|..:..  |::|.   ||. ..||.:.|.|||..||......
  Fly   127 NRSSQTYAWGANDVLNVFSHVSNGGEINLRFYNHDL---DFSPGYDAYEEDEWVFKRVKLLLQQK 188

Human   190 RNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGK 254
            |.     :....:.:||||||||:||.||.|:|.:..::..::|.:.||..|...|...: .|.:
  Fly   189 RE-----ALQRAQNVVFFLHLLGLDTAGHVHKPGAPKFRRTLEKTEKGVYAIYQEFERVF-PDKR 247

Human   255 TTFIFTSDHGMTDWGSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQFDDAFLKEWRLENWKRLDV 319
            |.::.|:||||||.|:||:|.|.||.||.:.||||   ..|...:.....|:...........::
  Fly   248 TAYLLTADHGMTDSGAHGSGSPHETDTPFMLWGAG---ASRAVPKPGGRTFMPNNEGPAMPLHEL 309

Human   320 NQADIAPLMTSLIGVPFPLNSVGILPVDYLNNTDLFKAESMFTNAVQILEQFKVKMTQKKEVTLP 384
            .||.:.|||::|:|:..|:|:.|.||:.|||.:..::|.:...||:|:|||:.....|.|:....
  Fly   310 EQAQLTPLMSALLGLAPPMNNFGKLPLGYLNVSKEYEAMAAHVNALQLLEQYVALQKQHKKGFFA 374

Human   385 FLFTPFKLLSDS--KQFN----ILRKARSYIKHRKFDEVVSLC----KELIHLALKGLSYYHTYD 439
            .:...:.:|:..  |::.    .|:|.|.|          |||    :.::..||:|:.|||.|.
  Fly   375 DILLEYDVLNAEAIKRYKDTIVQLQKKREY----------SLCIDKSQVIMSQALEGIDYYHGYY 429

Human   440 RFFLGVNVVIGFVGWISYASLLIIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLLIQAC 504
            |..|.::....|:||:.|...|:.::.::.::.|   :::.:.::..|.|:..|::...||.|..
  Fly   430 RRVLLLSTTSTFLGWMFYIYRLLSRNRASKVELV---LERSNKIVRVSIVSSVIVLIICLLSQGT 491

Human   505 PWTYYVYGLLPLPIWYAVLREFQV-IQDLVVSVLTYP-LSHFVGYLLAFTLGIEVLVLSFFYRYM 567
            |.....|.|||..:|...|:.:.: ......|..:.| |...:..|:......|::|.:||.|.:
  Fly   492 PLDISFYLLLPYFVWLKALQPWNINFSSSPASAYSVPALQTSMWQLVLLIACAELMVFTFFERRL 556

Human   568 LTAGLTAFAAWPFLTRLWTRAKMTS---LSWTFFSLLLAVFPLMPV-VGRKPDISLVMGAGLLVL 628
            :......||.:    ..|...:..|   .||....|:|:.|||:|: ||.:.  ..::|||::|:
  Fly   557 IALCFCVFACY----NSWENFQWKSRDFFSWLALVLILSCFPLLPLSVGYQN--GYLLGAGVIVI 615

Human   629 LLS--------LCVVTSLMKRKDSFIKEELLVHLLQVLSTVLSMYVVYSTQSSLLRKQG--LPLM 683
            ..:        ||.      |..:.....|:     :|.|:|..|         |...|  :|:.
  Fly   616 FTNSFWNSKSRLCY------RNHTKYSNALI-----LLQTILCAY---------LHSNGINIPIP 660

Human   684 NQIISWATLASSLVVPLLSSPV-LFQRLFSILLSLMSTYLLLSTGYEALFPLVLSCLMFVWINIE 747
            .::.||..|..:....|||... |..||..|..:|.|.|..|.|.|||:|..:|:..:.:.:..:
  Fly   661 LKLASWLYLVYAFASILLSKESRLDLRLAQIGFNLGSLYATLCTSYEAVFVQLLTIELNISLRAQ 725

Human   748 QETLQQSGVCCKQKLTSIQFSYNTDITQFRQLYLDDIRRAFFLVFFLVTAFFGTGNIASINSFDL 812
            ....::|                            .:|.||.|:.:...:.||:||||||:|||.
  Fly   726 SARAERS----------------------------VLRLAFTLLLYTFFSLFGSGNIASISSFDP 762

Human   813 ASVYCFLTVFSPFMMGALMMWKILIPFVLVMCAFEAVQLTTQLSSKSLFLIVLVISDIMALHFFF 877
            ....|:|:.|:||::..|::.|:|:|.||:|....|.....:...:.:|:.:|:|.|:|.|:|.|
  Fly   763 NIARCYLSHFAPFVIMGLVLLKLLVPVVLIMSVIYANSEFVRQHEEQIFICLLLICDVMGLNFLF 827

Human   878 LVKDYGSWLDIGTRQLLACTAWLFMYISASPNRLWMLSDPGLDLNLLHAIRACISHYVIV-MSMT 941
            ||::.||||||||                                       .|||:||: ::..
  Fly   828 LVRNQGSWLDIGT---------------------------------------SISHFVIMEVTTL 853

Human   942 IFLVFLNGLAQLL 954
            :.||......|||
  Fly   854 VMLVIFYTAKQLL 866

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIGN	NP_001425825.1	None
PIG-N	NP_610549.1	GPI_EPT_1	42..335	CDD:293744	126/308 (41%)
		PigN	420..834	CDD:461508	123/470 (26%)