Protein Alignment PIGN and PIG-G

DIOPT Version :10

• Sequence 1: NP_001425825.1
• Gene: PIGN / 23556
• HGNCID: 8967
• Length: 970
• Species: Homo sapiens
• Sequence 2: NP_610292.2
• Gene: PIG-G / 35685
• FlyBaseID: FBgn0033187
• Length: 927
• Species: Drosophila melanogaster
• Alignment Length: 1076
• Identity: 238/1076 - (22%)
• Similarity: 386/1076 - (35%)
• Gaps: 301/1076 - (27%)

Human     3 LFFTLGLLIHFVFFASIFDIYF------------TSP-----LVHGMTPQFTPLPPPARRLVLFV 50
            |.:|:|:|..|:..|.:|.|.|            |.|     .:.||  :.||.||.....||.:
  Fly     8 LVYTIGMLTAFLCGAVLFLIGFFPASYSVAEKESTVPEGRPTALLGM--ELTPPPPAYDSFVLLL 70

Human    51 ADGLRAD--------ALYELDENGNSRAPFIRNIIMHEGSWGISHTRVPTESRPGHVALIAGFYE 107
            .|.||.|        ..|       |||.....:          |..:||.:.|...::..|...
  Fly    71 VDALRDDFPDATSMPVAY-------SRACEKLKL----------HVDIPTVTMPRLKSITTGTLS 118

Human   108 DVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDAT 172
            :...:|..........||..:..|      ..:.:..||    |||.:...:.:   :|..| ..
  Fly   119 NFIDIALNVGHTEQMQDSFLHRLK------QQNRVVSFA----GDHTWVKLFPS---EFTRQ-VE 169

Human   173 KLDTWVFDNVKDFFHHARN-NQSLFSKI-NEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVD 235
            ..|::.   |.||:...|| .::|.::: ..:..:..||.||:|..||....:|......:|::|
  Fly   170 NHDSFY---VNDFYEGDRNVTKTLETELERSDWSLLILHYLGLDHIGHVEGNASPRVPLKLKEMD 231

Human   236 DGVKEIVSMFNHFYGNDGKT----TFIFTSDHGMTDWGSHGAGHPSETLTPLVTWGAGIKYPQRV 296
            :.||:|:         |.|:    ..:.|.||||.|.|.||...|:|||.||..:..........
  Fly   232 EVVKKIL---------DHKSFPNVLLMLTGDHGMADGGGHGGNTPAETLVPLYLYYNNCSKTPSA 287

Human   297 SAQQFDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLNSVGILPVDYLNNTDL-FKAESM 360
            |                 ||  .||.|:||.::.|:.|..|..|:|.|..:.|.:..| .:..:.
  Fly   288 S-----------------KR--YNQIDLAPTLSVLLSVEIPTLSIGCLIPEMLQSLSLEHQLYAY 333

Human   361 FTNAVQILEQFKVKM-----------TQKKEVTL--PFLFTPFK---------LLSDSKQFNILR 403
            |.||..:|.:.:||.           |..:..||  ..|..|.:         :...:.:.|.:|
  Fly   334 FYNAHHLLNKARVKFGHEIVHRSDYYTWYQNATLLHKKLLRPLREGDGGGASQVYYQNAKLNYMR 398

Human   404 KARSYIKHRKFDEVVSLCKE----------LIHLALKGLSYYH-TYDRFFLGVNVVIGFVG---- 453
            .||         |:..|..|          .:.|||...:..| .....:|.:...:...|
  Fly   399 VAR---------EISDLLSESLVKFDYGFIAVGLALTTSTSLHIVISVLYLDLTEQLQLDGLKVG 454

Human   454 --WISYASLLIIK--SHSNLIKGVSKEVKKPSHLLPCSF-VAIGILVAFFLLIQACP--WTYYVY 511
              |:|..:.:::.  ||:..|...|..:.....|:|.|. |.:.|.||..||..|.|  :|..:.
  Fly   455 QLWLSVIAAVVLNYTSHALDIIMTSSTLYSILLLVPISIAVYLTIDVAQALLKIALPPLYTRRLK 519

Human   512 GLLPLPIWYAVLREFQVIQDLVVSVLTYPLSHFV--GYLLAFTLGIEVLVLSFF--YRYMLT--- 569
            ..:|||:        .::....:..||...|.|:  .|...:.||..:::|:.|  .|:.:|
  Fly   520 ISIPLPL--------PLLACYAIRTLTLGSSSFIEFEYNTWYYLGNTLILLTAFRTLRWRITKTN 576

Human   570 -----AGLTAFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFPLMPVVGRKPDISLVMGAGLLVLL 629
                 ..|...|:    |.||...|:.        ::|.:..||..:.|...|...      |::
  Fly   577 VELNGRHLYTIAS----TCLWQMRKVL--------VVLMLLTLMRYIHRLQAIRST------VVI 623

Human   630 LSLCVVTSLMKRKDSFIKEELLVHLLQVLSTVLSMYVVY------------STQSSLLRKQGLPL 682
            .|:.::.:.:.|..         .|.|.|::..::::||            ...|.:..|..:|.
  Fly   624 FSMLLLWARLHRHS---------QLPQSLASGAALFMVYCFRGLNGQVLFFDVPSHMAAKLMVPT 679

Human   683 MNQIISWATLASSLVVPLLSSPVLFQRLFSI--------LLSLMSTYLLLSTGYEALFPLVLSCL 739
            :  :|.|..||   :|.:|.......:..|.        ||.|:.|.|..|....||...|.:.|
  Fly   680 L--VIFWCCLA---LVLMLGYRAALPQAHSFGKVPPTGALLQLLQTNLTSSLLLAALLQRVHNIL 739

Human   740 MFVWINIEQETLQQSGVCCKQKLTSIQFSYNTDITQFRQLYLDDIRRAFFLVFFLVTAFFGTGNI 804
            :...:.:   .|||:     .||..:   |.|...:| .:.|..:.:....:|.....||..||.
  Fly   740 LLPVLLV---ALQQT-----YKLCDV---YGTSARKF-SVRLVHVYKIIMTIFLARMFFFYQGNS 792

Human   805 ASINSFDLASVYCFLTVFSPFMMGALMMWKILIPFVLVMCAFEAVQLTTQLSSKSLFLIVLV--- 866
            .|:::.||...|...|.::|.::...                  |.|.|..:....||.::|
  Fly   793 NSLSTIDLTPGYIGQTNYNPSIVAIF------------------VTLNTYSADIHAFLYLVVHTL 839

Human   867 ISD-----IMALH-----------------FFFLVKDYGSWLDIGTRQLLACTAWLFMYISASPN 909
            .||     ||.||                 ...|...:...|.:|.|.      .||:|...||.
  Fly   840 RSDLRSVGIMQLHPPYSIAADSLIAPLYAALIMLPAAFYLCLLVGFRY------HLFIYSVFSPK 898

Human   910 RLWMLSDPGLDLNLLHAIRACISHYVIVMSMTIFLV 945
            .|:                .|   |.:::...:|||
  Fly   899 VLY----------------DC---YTVLVFYLVFLV 915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIGN	NP_001425825.1	None
PIG-G	NP_610292.2	GPI_EPT_2	60..317	CDD:293748	78/318 (25%)
		PIGO_PIGG	<776..901	CDD:437148	32/148 (22%)