Protein Alignment PSD4 and siz

DIOPT Version :10

• Sequence 1: NP_036587.2
• Gene: PSD4 / 23550
• HGNCID: 19096
• Length: 1056
• Species: Homo sapiens
• Sequence 2: NP_730594.1
• Gene: siz / 40327
• FlyBaseID: FBgn0026179
• Length: 1325
• Species: Drosophila melanogaster
• Alignment Length: 986
• Identity: 206/986 - (20%)
• Similarity: 326/986 - (33%)
• Gaps: 330/986 - (33%)

Human    88 QEQTRATDPPESTRQDAPPWGS--GVELTHLGSPSAQREHRQNTASP-------GSPVN------ 137
            |:|.:....|..|....|...:  |:..|......:.||.||...||       .||.:
  Fly   407 QQQAQQQQQPRVTIMAGPAGAASPGLSRTPPTRSLSMRERRQLDCSPIPRSQSGASPASISSSTV 471

Human   138 --SHLPGSPKQNRSTSTQVVFWAGILQAQMCVLDLEEELEKTEGLKAGLKCCLPTPPVDLPGDTG 200
              |.|...|..|            :|.|      .|......:.|..|....           |.
  Fly   472 STSALASHPHVN------------LLHA------AEPHYYNAQALPQGAAYY-----------TS 507

Human   201 LHSSPPENEDSGEDSSEPEGEGQAWLR-EGTPDSSPQWGAEEESMFFSNPLFLASP-CSENSASG 263
            .|.||   .|....||.......:|:. .|....:|.:.|.:..|.........:| ||.::.||
  Fly   508 YHGSP---HDLSYASSADTSLNASWVNTSGHSPHTPYYSAAQIYMRPKGGSTTPTPSCSGSTGSG 569

Human   264 ECFSWGASDSHAGVRTGPESP-ATLEPPLPEDTVLWELESEPDLGDGAAISGHCTPPFPVPIYKP 327
            .    |.|.|.:..:..||.| .|......:.|.|..|:.:             ||| |..:.:.
  Fly   570 S----GGSGSGSSKKVPPEVPKRTSSITAQQQTQLLLLQRQ-------------TPP-PPSLLRT 616

Human   328 HSICWASVAAAEGAPAAPPGHGESEGDRLGPAPSAAPCVDEALTWESGCVGSDLGPAAHPVQPWA 392
            :.:|   ..|..|:..:....|.                |.::|.....:.||||..       .
  Fly   617 NGLC---KTAENGSLTSVQSSGS----------------DSSVTSAERNLNSDLGSD-------R 655

Human   393 SLSPEGWQRGGPFWPQVTLNSQDRDEREGGHPQESLPCTLAPCPWRSPASSPEPSSPESESRGPG 457
            |.||..|:||      ..||                             ||.:.|:..::|.|
  Fly   656 SNSPHTWKRG------TALN-----------------------------SSQQFSTHSADSAG-- 683

Human   458 PRPSPASSQEGSPQLQHHSSGILPKWTLDASQSSLLETDGEQPSSLKKKEAGEAPKPGEEVKSEG 522
                 |.|..|        .|:.....:.|:|.        |.:......||..|
  Fly   684 -----AVSGGG--------VGVAGGAGVYAAQM--------QAAVAAATAAGGMP---------- 717

Human   523 TARPAETGDVQPDIHLTSAEHENLRTPMNSSWLPGSPMPQAQSPEEGQRPPAGDKLANGVRNNKV 587
               ||:  |.....|.::|::|.                ..|...|.|:..|....|...:|.|:
  Fly   718 ---PAD--DHAISSHTSAAQYEQ----------------HEQQQHEQQQLQAAAAAAGVAQNYKM 761

Human   588 AWNLASRLYRL------------------EGFRKSE---VAAYLQKNNDFSRAVAEEYLSFFQ-- 629
            :..:..|.||:                  .||.::.   ||.:|......||.:..|||...|
  Fly   762 SETIRKRQYRVGLNLFNKKPEKGITYLIRRGFLENTPQGVARFLITRKGLSRQMIGEYLGNLQNQ 826

Human   630 --------------FGGQSLDRALRSFLQALVLSGETQERERILYQFSRRFHHCNP---GIFPSV 677
                          ..|:.:|.|||.|.....:.||.|:.||::..||:|:..||.   |...|.
  Fly   827 FNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQRYCECNADIVGRLRSS 891

Human   678 DSVHTLTCAIMLLNTDLHGQNI--GKSMSCQEFITNLNGLRDGGNFPKELLKALYWSIRSEKLEW 740
            |::..|..||::||||||..|:  .:.|..::||.||.|:.|..:..|::|..:|..::|:  |:
  Fly   892 DTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHDIDKDMLMGIYDRVKSD--EF 954

Human   741 AVDEEDTARPEKAQPSLPAGKMSKPFLQLAQDPTVPTYKQGILARKMHQ--DADGKKTPW-GKRG 802
            ....:...:..|.|.:: .||  ||.|.|       .:::.:...::::  |.:.|:.|. .:|.
  Fly   955 KPGSDHVTQVMKVQATI-VGK--KPNLAL-------PHRRLVCYCRLYEIPDVNKKERPGVHQRE 1009

Human   803 WKMFHTLL---------RGMVLYFLKQGEDHCLEGESLVGQMVDEPVGVHHSLATPATHYTKKPH 858
            ..:|:.||         :..|.|..:.....|    ..|..::|.|            :|   |.
  Fly  1010 VFLFNDLLVITKIFSKKKTSVTYTFRNSFPLC----GTVVTLLDMP------------NY---PF 1055

Human   859 VFQL-RTADWRLYL-FQAPT-------AKEMSSWIARIN-------------LAAATHSAP---- 897
            ..|| :..|.::.: |.|..       |:::...|:.::             ..:|.:.||
  Fly  1056 CIQLSQKVDGKILITFNARNEHDRCKFAEDLKESISEMDEMESLRIEAELERQKSARNRAPGNAE 1120

Human   898 ------------PFPAAVGSQRRFVRPILPVGPAQSSLEEQHRSHENC----LDAAADDLLDLQR 946
                        |.|...||              |:|.|:...|.:|.    ..|.::.|||:..
  Fly  1121 NRDSGVADVEVCPCPYQQGS--------------QASGEQAPNSADNSQQLKRSALSNSLLDMHE 1171

Human   947 NL----PERRG 953
            ..    |:|||
  Fly  1172 QFGNEKPQRRG 1182

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PSD4	NP_036587.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..71
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..149		19/77 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	195..239		10/44 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	340..362		2/21 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	388..533		26/144 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	546..581		5/34 (15%)
		Sec7	570..738	CDD:238100	59/209 (28%)
		PH_EFA6	772..900	CDD:270107	26/177 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1004..1056
siz	NP_730594.1	Sec7	766..954	CDD:460178	54/189 (29%)
		PH_IQSEC	981..1108	CDD:270128	22/145 (15%)