DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FOSB and Atf3

DIOPT Version :9

Sequence 1:	NP_006723.2	Gene:	FOSB / 2354	HGNCID:	3797	Length:	338	Species:	Homo sapiens
Sequence 2:	NP_001259125.1	Gene:	Atf3 / 43867	FlyBaseID:	FBgn0028550	Length:	688	Species:	Drosophila melanogaster

Alignment Length:	376	Identity:	89/376 - (23%)
Similarity:	149/376 - (39%)	Gaps:	83/376 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    16 SSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFV--PTVTAITTS--QDLQWLVQPTL- 75
            |:|.||.|..:.:|..|...|...:..:.:......||.:  |..||.|.|  |....|::..|
  Fly    63 SASCSAASTPVVTVRHFNGHPNGQSHSQDSSHSSCSGSPLDSPAGTATTPSVQQTCSRLIKEGLK 127

Human    76 --------ISSMAQSQGQPLASQPPVVDPYDMPGTSYS--TPGMSGYSSGGASGSGGPSTSGTTS 130
                    :|:...|.|.            :.|.:.||  :...:|:|....:.||..|.:....
  Fly   128 LSIQSKRKLSTCDSSSGS------------EQPHSKYSRRSSNHNGHSGSSNNYSGSMSNANDLD 180

Human   131 GPGPARPARARPRRPREETLTPEEEEKRRVRRERNKLAAAKCRNRRRELTDRLQAETDQLEEEKA 195
            .............:.:.:.||||:|::||.||||||:||.|||.::||.|..|..|::.|:.:..
  Fly   181 DDCEESSDDDSETKSQPKGLTPEDEDRRRRRRERNKIAATKCRMKKRERTQNLIKESEVLDTQNV 245

Human   196 ELESEIAELQKEKERLEFVLVAH----KPGCKIPYE--------------------EGPGPGPLA 236
            ||::::.:|:.|:::|..:|.:|    ..||::|.:                    :||..|...
  Fly   246 ELKNQVRQLETERQKLVDMLKSHGCQRAGGCQLPSQLLQSPAQKYLSELELETVSIDGPNSGNNN 310

Human   237 E-VRDLPGSAPAK-----EDGFSWLLP----PPPPPPLPF----------QTSQDAPPNLTASLF 281
            : ::.:|..|..|     ....:..||    .|.|....|          |..|..|.:|..
  Fly   311 QRLQSIPSMATFKYGSKTAAAMAQQLPNGYCKPSPSAQEFEHAGYQQQQQQQQQQQPQSLNP--- 372

Human   282 THSEVQVLGDPFPVVNPSYTSSFVLTCPEVSAFAGAQRTSGSDQPSDPLNS 332
              :...|:.......:||..|.:|..|..::.       |.|:.||...|:
  Fly   373 --AGNNVIDQQHANPSPSLLSDYVPNCDGLTG-------SASNHPSHNNNN 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FOSB	NP_006723.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54		9/37 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	79..191		33/113 (29%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	157..182		16/24 (67%)
		bZIP_Fos	165..218	CDD:269869	19/52 (37%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	183..211		7/27 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	222..276		16/93 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..338		5/17 (29%)
Atf3	NP_001259125.1	bZIP_ATF3	215..268	CDD:269870	19/52 (37%)
Atf3	NP_001259125.1	coiled coil	215..265	CDD:269870	18/49 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143233
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1414
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740