DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FOSB and kay

DIOPT Version :9

Sequence 1:	NP_006723.2	Gene:	FOSB / 2354	HGNCID:	3797	Length:	338	Species:	Homo sapiens
Sequence 2:	NP_001027577.2	Gene:	kay / 3772082	FlyBaseID:	FBgn0001297	Length:	755	Species:	Drosophila melanogaster

Alignment Length:	223	Identity:	73/223 - (32%)
Similarity:	98/223 - (43%)	Gaps:	58/223 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    44 CAGLGEMPGSFVPTVTAITTSQDLQWLVQPTLISSMAQSQ------GQPLASQPPVVDPYD---- 98
            |||..      ||.|  :..:.|:..:..||.:||:...|      ||...|:.......|
  Fly   279 CAGFA------VPKV--LPNAIDVLGMGIPTGVSSLPLQQTFDLSLGQGSESEDSNASYNDTQMN 335

Human    99 ------------MPGTSYST----------PGMSGYSS---------GGAS-GSGGPSTSGTTSG 131
                        ...|||..          .|::.:|:         |.|| ||...:||.|
  Fly   336 EEQDTTDTSSAHTDSTSYQAGHIMAGSVNGGGVNNFSNVLAAVSSSRGSASVGSSNANTSNT--- 397

Human   132 PGPARPARARPRRPREET-LTPEEEEKRRVRRERNKLAAAKCRNRRRELTDRLQAETDQLEEEKA 195
              |||  |...|||...| :|||||:||.|||||||.|||:||.||.:.|:.|..|.:|||:...
  Fly   398 --PAR--RGGGRRPNRSTNMTPEEEQKRAVRRERNKQAAARCRKRRVDQTNELTEEVEQLEKRGE 458

Human   196 ELESEIAELQKEKERLEFVLVAHKPGCK 223
            .:..||..|...|.:||::|..|:..|:
  Fly   459 SMRKEIEVLTNSKNQLEYLLATHRATCQ 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FOSB	NP_006723.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54		3/9 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	79..191		51/154 (33%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	157..182		17/24 (71%)
		bZIP_Fos	165..218	CDD:269869	22/52 (42%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	183..211		9/27 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	222..276		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..338
kay	NP_001027577.2	bZIP_Fos	420..481	CDD:269869	29/60 (48%)
kay	NP_001027577.2	coiled coil	421..480	CDD:269869	28/58 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1414
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42280
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23351
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.870