Protein Alignment TNPO3 and MTR10

DIOPT Version :10

• Sequence 1: NP_001369145.1
• Gene: TNPO3 / 23534
• HGNCID: 17103
• Length: 957
• Species: Homo sapiens
• Sequence 2: NP_014803.1
• Gene: MTR10 / 854331
• SGDID: S000005686
• Length: 972
• Species: Saccharomyces cerevisiae
• Alignment Length: 946
• Identity: 234/946 - (24%)
• Similarity: 399/946 - (42%)
• Gaps: 176/946 - (18%)

Human    14 AVQALYHDPDPSGKERASFWLGELQRSVHAWEISDQLLQIRQD-----VESCYFAAQTMKMKIQT 73
            |:|.:........|.:|..:|.:.|||..||.|.:::|. ::|     :|...|||||::.|:..
Yeast    12 ALQCISSTASQDDKNKALQFLEQFQRSTVAWSICNEILS-KEDPTNALLELNIFAAQTLRNKVTY 75

Human    74 SFYELPTDSHASLRDSLLT----HIQNLKDLSPVIVTQLALAIADLALQMPSWKGCVQTLVEKYS 134
            ...:| .::....:|||||    |.|.|      |:|||.:|:|.||:|...|:..:..::...:
Yeast    76 DLSQL-ENNLPQFKDSLLTLLLSHNQKL------IITQLNVALARLAIQFLEWQNPIFEIISLLN 133

Human   135 NDVTSLPFLLEILTVLPEE---VHSRSL-RIGANRRT-EIIEDLAFYSSTVVSLLMTCVE-KAGT 193
               :|...||..|.:||||   :.|.|| .:..|.|. |:|:.:|   ..|:..|::|:: ...|
Yeast   134 ---SSPSILLNFLRILPEETLDIASTSLTEVEFNSRIHELIDPIA---EDVLKFLVSCIDLLQNT 192

Human   194 DEK-----MLMKVFRCLGSW-FNLGVLDSNFMANNKLLALLFEVLQQ-DKTSSNLHEAASDCVCS 251
            |..     .|.::.|||.|| :...|  ...:....|:.|:||.:.. :::.....::|.||:|.
Yeast   193 DGNSSSSISLEQILRCLNSWSYEFPV--EQLLTVQPLINLVFETISNGNESDMEAFDSAIDCLCV 255

Human   252 ALYAIENVETNLPLAMQLFQGVLTLE-----TAY--HMAVAREDLDKVLNYCRIFTELCETFLEK 309
            .|....:. ||..|...||..::.|:     |.:  |......|.|.:....|:|.|..|.:  .
Yeast   256 ILRESRDT-TNEQLISALFHQLMLLQEKLLPTLFTDHPLNDEYDDDLLEGMTRLFVEAGEAW--S 317

Human   310 IVCTPGQGLGDLRTLELLLICAGHPQYEVVEISFNFWYRLGEHL----YKTNDEVIHGIFKAYIQ 370
            :|.:..........|.||::...:...:||..:|.||:...:.|    |:.:.:....||    .
Yeast   318 VVISKNPDFFKPMVLVLLMLTCKNEDLDVVSYTFPFWFNFKQSLVLPRYQESRKAYSDIF----V 378

Human   371 RLLHALARHCQLEPDHEGVPEETDDFGEFRMRVSDLVKDLIFLIGSMECFAQLYSTLK---EGNP 432
            :|::.:..|.|.........||.|.|.:||..:.|::||...::|:.|..:|....:|   |.|.
Yeast   379 KLINGIITHLQYPSGQFSSKEEEDKFKDFRYHMGDVLKDCTAVVGTSEALSQPLIRIKSAIENNN 443

Human   433 PWEVTEAVLFIMAAIAKSVDPKKPFSNAVCRHSLLFGQNITSEISNCEYLPPVLRENNPTLVEVL 497
            .|::.||.||.:..:||                         |||..|         |..|.|::
Yeast   444 SWQIMEAPLFSLRTMAK-------------------------EISLTE---------NTILPEII 474

Human   498 EGVVRLPETVHTAVRYTSIELVGEMSEVVDRNPQFLDPVLGYLMKG--LCE-----KPLASAAAK 555
            :.:..|||  ...:||.|..::|..:|...::|:.|:..|.|:..|  |.|     :.:.:|::.
Yeast   475 KIICNLPE--QAKIRYASTLVLGRYTEWTAKHPELLEVQLQYIFNGFQLHEGSSDMQSIITASSH 537

Human   556 AIHNICSVCR----DHMAQHFNGLLEIARSLDSFLLSPEAAVGLLKGTALVLARLPLDKITECLS 616
            |:...||.|.    .::.|..|..|.:..|:|.     |:...|.:|.:.|:...|..|::....
Yeast   538 ALMFFCSDCSKLLVGYIDQLINFFLNVQSSIDI-----ESQFELCQGLSAVINNQPEAKVSVIFQ 597

Human   617 ELCSVQVMALKKLLSQEPSNGISSDPTVF-------LDRLAVIFRHTNPIVENGQ--THPCQKVI 672
            :|....:..::.|:.|..:|     ||:.       :|.|..:|....|.....|  :.|....|
Yeast   598 KLVDDNLRQIEALIPQWKAN-----PTLLAPQIADKIDLLYALFEELKPRYNYPQQGSEPLLPRI 657

Human   673 QEIWPVLSETLNKHRA--DNRIVERCCRCL-----RFAVRCVGKGSAALLQPLVTQMVNVYHVHQ 730
            :.||..|...|....|  |:.||||..:.|     ||.|.|     ..:|..:...::..|....
Yeast   658 EFIWKALRTLLVDAGAMTDSIIVERVAKLLRRIFERFHVFC-----EPILPSVAEFLIQGYLTTG 717

Human   731 HSCFLYLGSILVDEYGMEEG------------------CRQGLLDMLQALCIPTFQLLEQQNGLQ 777
            ...:|:....|:..:|.:|.                  |...:|:..:      |..|:    |.
Yeast   718 FGSYLWCSGSLIVIFGDDESFPISPSLKDAVWKFALSQCETFILNFNK------FDKLQ----LN 772

Human   778 NHPDTVDDLFRLATRFIQRSPVTLLRS-QVVIPILQWAIASTT-LDHRDANCSVMRFLRDLIHTG 840
            ::.:.:.|.|.|.:..|...|...|.| :::.|:|..|:.... ||:.||...::|.|.|:|..|
Yeast   773 DYHEAIIDFFSLISDLIMFYPGAFLNSTELLGPVLNVALECVNKLDNYDAYICILRCLDDIISWG 837

Human   841 --------VANDHEEDFELRKELIGQVMNQLGQQLV 868
                    |:.:...| |.||::|.:|:...|.||:
Yeast   838 FKTPPISTVSIEIVPD-EWRKQVINEVVIAHGNQLI 872

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TNPO3	NP_001369145.1	IBN_N	33..96	CDD:197981	23/71 (32%)
		Xpo1	121..249	CDD:462459	35/140 (25%)
MTR10	NP_014803.1	IBN_N	28..97	CDD:197981	23/70 (33%)
		Xpo1	100..253	CDD:462459	46/166 (28%)