Protein Alignment TNPO3 and mtr10

DIOPT Version :10

• Sequence 1: NP_001369145.1
• Gene: TNPO3 / 23534
• HGNCID: 17103
• Length: 957
• Species: Homo sapiens
• Sequence 2: NP_595725.2
• Gene: mtr10 / 2539916
• PomBaseID: SPBC11G11.07
• Length: 955
• Species: Schizosaccharomyces pombe
• Alignment Length: 1007
• Identity: 246/1007 - (24%)
• Similarity: 439/1007 - (43%)
• Gaps: 123/1007 - (12%)

Human     8 LQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAWEISDQLL-QIRQDVESCYFAAQTMKMKI 71
            ::.:..|:..||.:.|...|.:|:.:|.|.|:|..||:|...:| |....:|:..|||||::.||
pombe     1 METLLSALATLYANTDREQKLQANNYLEEFQKSPAAWQICFSILNQDDSSIEAKLFAAQTLRQKI 65

Human    72 QTSFYELPTDSHASLRDSLLTHIQNLKDLSPVIVTQLALAIADLALQMPSWKGCVQTLVEKYSND 136
            ...|::||.::|...|:|||......||....::..||:.:|.:||.|..|...:..:.:..|:.
pombe    66 VYDFHQLPKETHIEFRNSLLQLFLAAKDSPRPLLVSLAVCMAAIALHMTEWHNVIADVFQACSSK 130

Human   137 VTSLPFLLEILTVLPEEVH-----SRSLRIGANRRTEIIEDLAFYSSTVVSLL---MTCVEKAGT 193
            ..|...:|:.|:|||||..     |.|......|..|::.|   ....|:.||   :..|..:|:
pombe   131 DPSGRCVLQFLSVLPEEASDPRKTSLSWEELCIRVDELLRD---NGPAVLELLVQYVDAVRASGS 192

Human   194 DEKM-LMKVFRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSNLHEAASDCVCSALYAIE 257
            .... |..|...|.||.....|| ..|| :.|:.|.|..|..|.    |.|.|.:.:|:.....:
pombe   193 PSSADLGLVLTSLISWLREIPLD-KVMA-SPLIELAFRSLDDDL----LLEDAVEFLCALFNETK 251

Human   258 NVETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLNYCRIFTELCETFLEKIVCTPGQGLGDLR 322
            :|:......:.|:..:|.|:.  .:..|.:|.:......|:|.|..|.::..|...|...|..:.
pombe   252 DVDETTDAILMLYPRLLELQP--KLIAACDDPETFRALGRLFAEAGEAWVVLIARMPNDFLPLVN 314

Human   323 TLELLLICAGHPQYEVVEISFNFWYRLGEHLYKTNDEVIHGIFKAYIQRLLHALARHCQLEPDHE 387
            .  :..:.|...:.|.::.:|.||:.|.:.:..........:|......|:..:.||... |..|
pombe   315 C--IAQVAANDTELEAIKFTFAFWWDLKQMVELDVYAEARQLFAPIYLELVRIIVRHLHY-PRTE 376

Human   388 GVP---------------EETDDFGEFRMRVSDLVKDLIFLIGSMECFAQLYSTL------KEGN 431
            .:.               :..|.|..||..:.|::||...:.|...|..|:.|.|      ||..
pombe   377 DLAINEQMASNEVLFEDRDAEDRFRSFRHEMGDVLKDCCVVAGVSSCLVQISSQLIKVLKIKESG 441

Human   432 PP--WEVTEAVLFIMAAIAKSVDPKKPFSNAVCRHSLLFGQNITSEISNCEYLPPVLRENNPTLV 494
            .|  |:..||.||.:.||.:.|.                 .|....|.:...:.|.|.|||
pombe   442 LPYYWQDVEAPLFALRAIGRMVP-----------------ANEDQVIGSLFQILPQLPENN---- 485

Human   495 EVLEGVVRLPETVHTAVRYTSIELVGEMSEVVDRNPQFLDPVLGYLMKG--LCEKPLASAAAKAI 557
                           .|||.:...:|..:|...::.:||:..|.|:..|  :..|.:.||||:|:
pombe   486 ---------------KVRYAATLFLGRYTEWTAQHSEFLELQLNYISAGFEVANKEVQSAAAQAL 535

Human   558 HNICSVCRDHMAQHFNGLLEIARSLDSFLLSPEAAVGLLKGTALVLARLPLDKITECLSELCSVQ 622
            .:.|..||:.:..|.:.|.....:..:: |:|:..:.:.:|.|.::...|:..:.:.:....:..
pombe   536 KHFCYDCREQLVGHLSQLHMFYLNAKTY-LAPDPLMEVAQGLAHIVDIQPVANVYQSVHSFLAPS 599

Human   623 VMALKKLLSQEPSNGISSDPTVFLDRLAVI---FRHTNPIVENGQTHPCQKVIQEIWPVLSETLN 684
            :.::  ||:|...|...::.....|.:.::   ....:|....|:.||..::.|:|||:||.||:
pombe   600 LQSI--LLAQVKLNPTQAELEALADNIDIVTIFLSLVHPPSPAGELHPIVRLFQDIWPILSRTLD 662

Human   685 KHRADNRIVERCCRCLRFAVRCVGKGSAALLQPLVTQ-MVNVYHVHQHSCFLYLGSILVDEYG-- 746
            .. :|..|.||..:.|:..:... |..|.:..|::|: ::..:...|:.|||::....|.::|
pombe   663 TF-SDVLICERISKLLKNFIYTF-KEKAIVTLPVITEALIKGFEKTQYGCFLWVSGACVRQFGVP 725

Human   747 -MEEGCRQGLLDMLQALCIPTFQLLEQQNGLQNHPDTVDDLFRLATRFIQRSPVTLLRSQVVIPI 810
             |:|.....:...:...|...|..:..:|. :..||.:||.|||....:..:|..:|.||::..:
pombe   726 EMDEQTLSAVWSFVGKQCTNMFYYMSNKNP-KEIPDVIDDFFRLMMDALLANPQMVLESQMLESL 789

Human   811 LQWAIASTTLDHRDANCSVMRFLRDLIHTGVANDHEEDFELRKELIGQVMNQL-------GQQLV 868
            :|.|:.|..|:.::...:|:.||:||:...:   |...:.|.:.|...::..|       .|:|.
pombe   790 IQAAMMSLQLEQQEPLQTVLNFLQDLLAFAL---HTPPYSLIEPLPDSLLKSLADLLLKNSQELY 851

Human   869 SQLLHTCCFCLPPYTLPDVAEVLWEIMQV---DRPTFC-RWLENSLKGLPKETTVGAVTV----T 925
            ..|.:...|..|...:.|.:.||..::::   ..|:.| :::.|.|..||      |:|:    .
pombe   852 IILFNGMVFTFPRDNISDASAVLIPLIRLVFAADPSLCIKYMSNVLDQLP------AMTIGQEER 910

Human   926 HKQLTDFHKQVTSAEECKQVCWALRDFTRLFR 957
            .|.|.:|.|..||: |..::...|:|:|.::|
pombe   911 EKFLANFSKHCTSS-EMPRLRAHLQDWTAMYR 941

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TNPO3	NP_001369145.1	IBN_N	33..96	CDD:197981	25/63 (40%)
		Xpo1	121..249	CDD:462459	37/136 (27%)
mtr10	NP_595725.2	IBN_N	23..89	CDD:197981	26/65 (40%)
		Xpo1	95..243	CDD:462459	43/156 (28%)