Protein Alignment TNPO3 and tsr-1

DIOPT Version :10

• Sequence 1: NP_001369145.1
• Gene: TNPO3 / 23534
• HGNCID: 17103
• Length: 957
• Species: Homo sapiens
• Sequence 2: NP_001370995.1
• Gene: tsr-1 / 173601
• WormBaseID: WBGene00006647
• Length: 829
• Species: Caenorhabditis elegans
• Alignment Length: 871
• Identity: 246/871 - (28%)
• Similarity: 418/871 - (47%)
• Gaps: 103/871 - (11%)

Human   144 LEILTVLPEEVHSRSLR-IGANRRTEIIEDLAFYSSTVVSLLMTCVEKAGTDEKMLMKVFRCLGS 207
            |.:|.|.||||  ..:| :|.|||..|..:||.....:::.|...:||..::..:|.:||:||.|
 Worm     3 LTLLQVFPEEV--EQIRGVGENRRHAIRNELAACEQPMITFLSHVLEKFHSNADVLKRVFKCLES 65

Human   208 WFNLGVLDSNFMANNKLLALLFEVLQ--QDKTSSNLHEAASDCVCSALYAIENVETNLPLAMQLF 270
            ......:.::..|.:.|::::|.|:.  .....|.|||.|::|:..|||.:|::|.:..||..:.
 Worm    66 NLQNHQMRTDHFAASPLISMIFHVIASIDPIIPSCLHETATNCIVQALYRVEDLEMHRKLAEVVH 130

Human   271 QGVLTLETAYHMAVAREDLDKVLNYCRIFTELCETFLEKIV--CTPG-QGLGDLRTLELLLICAG 332
            :||::|.:|:..|...||.|::.|..|||.|:.|:|..:||  ..|. ..:|.|...||||:.|.
 Worm   131 RGVISLVSAFEKAQQVEDFDRLQNIARIFVEMVESFYVQIVNEANPDPAAIGSLACFELLLLVAK 195

Human   333 HPQYEVVEISFNFWYRLGEHLYKTNDEVIHGIFKAYIQRLLHALARHCQLEPDH-EGVPEETDDF 396
            |..:.::|:|||.|||:.|.|:|.:|:...|.|:.|.::.:..|..||:|:.|. :.:.:||.:|
 Worm   196 HHDWALIEMSFNVWYRITEELFKYDDDQYIGRFRPYAEKFIQCLYEHCKLDADDVDDLLDETSEF 260

Human   397 GEFRMRVSDLVKDLIFLIGSMECFAQLYSTLKE----GNPPWEVTEAVLFIMAAIAKSVDPKKPF 457
            ||||::..:.::|::|::.|.:|...::..|.|    .|..||.:|:.||:|:|:.:::.|
 Worm   261 GEFRLKAVEALRDVVFIVNSDKCIQMMHQKLIECCHKPNASWEESESALFVMSAVVQNLLP---- 321

Human   458 SNAVCRHSLLFGQNITSEISNCEYLPPVLRENNPTLVEVLEGVVRLPETVHTAVRYTSIELVGEM 522
                                          |::..:.|||:.:..||.....|:..||:.|:.::
 Worm   322 ------------------------------ESDTNMPEVLQLICSLPVQSPPALIATSLSLISDL 356

Human   523 SEVVDRNPQFLDPVLGYLMKGLCEKPLASAAAKAIHNICSVCRDHMAQHFNGLLEIARSLDSFLL 587
            ::..:::...|:||:.:.::...:...||..|.....|.|.|...|......||.:...|:....
 Worm   357 NDWFEQHSNLLEPVVRWTLQFATDTRYASHVALCFDRITSKCAVQMTPLLPQLLTLIGVLEQTTT 421

Human   588 S----PEAAVGLLKGTALVLARLPLDKITECLSELCSVQVMAL---------------------- 626
            :    .||...|.:..:::.::||..:....:.:||...|..|
 Worm   422 NGAKVEEAICSLTRAISMIASKLPAHEAKIAMEQLCEPIVRNLLRATDATDATFAASSTNNNTAG 486

Human   627 ------KKLLSQEPSNG---------ISSDPTVFLDRLAVIFRHTNPIVENGQTHPCQK-----V 671
                  .|.....|..|         :::.|.:::||.|.:|:   .:..:|...|..:     |
 Worm   487 AGAAGANKENEGAPPRGSKANEAWASLATRPMLWIDRCACVFK---DVWTSGSKQPPAEIPWFTV 548

Human   672 IQEIWPVLSETLNKHRADNRIVERCCRCLRFAVRCVGKGSAALLQPLVTQMVNVYHVHQHSCFLY 736
            ||:....|.::..|.....|::|...|..|...|.:|..|...::|:||.|:..|..|:||.:||
 Worm   549 IQQCIDALLKSTRKFEGTPRLIEHSIRSCRLIFRALGAQSMPFVEPVVTMMIETYPKHRHSSYLY 613

Human   737 LGSILVDEYGMEEGCRQGLLDMLQALCIPTFQLLEQQNGLQNHPDTVDDLFRLATRFIQRSPVTL 801
            |.|::|||||..:..|.|||.||..|...||.||..| |..|||||||||||||.||..|:....
 Worm   614 LASVIVDEYGQLDKMRPGLLQMLDTLARHTFPLLVGQ-GAINHPDTVDDLFRLAQRFTMRATSIF 677

Human   802 LRSQVVIPILQWAIASTTLDHRDANCSVMRFLRDLIHTGVANDHEEDFELRKELIGQ-VMNQLGQ 865
            ....|...:...|:.:..|||.|||.||.:|:.:::.. :|...:..:........| ::|:..|
 Worm   678 FTDPVSELLFICAVLNIRLDHPDANRSVNKFIMEVLEQ-LATAKKASYTDAGVTAAQTLVNRNAQ 741

Human   866 QLVSQLLHTCCFCLPPYTLPDVAEVLWEIMQVDRPTFCRWLENSLKGLPKETTVGAVTVTHKQLT 930
            .:|:..|..|.|........::|:|:.::.:.|...:.:.|..::..||.:    .|..|.:|||
 Worm   742 SIVTNALSMCLFSHSGQIRREMADVVLQVGRNDPSKYKQILTQAVAALPND----PVKATPQQLT 802

Human   931 DFHKQVTSAEECKQVCWALRDFTRLF 956
            :|.:.|....|...|....||..:||
 Worm   803 EFVEAVCKERERHAVFNHTRDLAKLF 828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TNPO3	NP_001369145.1	IBN_N	33..96	CDD:197981
		Xpo1	121..249	CDD:462459	33/107 (31%)
tsr-1	NP_001370995.1	None