Protein Alignment ZNF281 and trem

DIOPT Version :9

• Sequence 1: NP_001268222.1
• Gene: ZNF281 / 23528
• HGNCID: 13075
• Length: 895
• Species: Homo sapiens
• Sequence 2: NP_650861.1
• Gene: trem / 42392
• FlyBaseID: FBgn0038767
• Length: 439
• Species: Drosophila melanogaster
• Alignment Length: 278
• Identity: 80/278 - (28%)
• Similarity: 122/278 - (43%)
• Gaps: 46/278 - (16%)

Human   131 KPADPEEQQSHHHHHHHHYGGLFAGAEERSPGLGGGEGGSHGVIQDLSILHQHVQQQPAQHHRDV 195
            :|...|.:::..:..:..|..|   ..|.||.: ..|.||.|.  |::     .::.|.:...:.
  Fly   166 QPVPNEIEEAETYAEYEEYELL---TNENSPEI-AQEKGSTGT--DVA-----TEEPPEEEIAED 219

Human   196 LLSSSSRTDDHHGTEEPKQDTNVKK-----AKRPKPESQGIKAKRKPSASSKPSLVGDGEGAILS 255
            :|.|....|..|...| |.|.:.:|     ...||.|:...|..||| .:...:.:.|..|.|.
  Fly   220 ILDSDEDYDPTHAKPE-KCDRSGRKPVAYHKNSPKVETFKKKVGRKP-RNKLSTYICDVCGNIY- 281

Human   256 PSQ-------------KPHICDHCSAAFRSSYHLRRHVLIHTGERPFQCSQCSMGFIQKYLLQRH 307
            |:|             |||.|:.|...|..:..|.||:..|||.||::|:.|...|..:....:|
  Fly   282 PTQARLTEHMKFHSGVKPHECEICGRGFVQNQQLVRHMNTHTGNRPYKCNYCPAAFADRSTKTKH 346

Human   308 EKIHSREKPFGCDQCSMKFIQKYHMERHKRTHSGEKPYKCDTCQQYFSRTDRLLKHRRTCGEVI- 371
            .:||::|:|:.||.||..|....:::.||..|:||||:.||.|.:.|.:..:|..||.|....|
  Fly   347 HRIHTKERPYVCDVCSRTFTYSDNLKFHKMIHTGEKPHVCDLCGKGFVKAYKLRLHRETHNRRIT 411

Human   372 -------------VKGAT 376
                         |||.|
  Fly   412 WRNDAEESTKAEDVKGET 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZNF281	NP_001268222.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	63..113
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	130..149		2/17 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	183..253		18/74 (24%)
		C2H2 Zn finger	263..283	CDD:275368	6/19 (32%)
		zf-H2C2_2	275..300	CDD:316026	11/24 (46%)
		C2H2 Zn finger	291..311	CDD:275368	4/19 (21%)
		zf-H2C2_2	304..328	CDD:316026	10/23 (43%)
		C2H2 Zn finger	319..339	CDD:275368	7/19 (37%)
		zf-H2C2_2	331..356	CDD:316026	11/24 (46%)
		C2H2 Zn finger	347..366	CDD:275368	7/18 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..427		80/278 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	638..660
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	778..817
trem	NP_650861.1	zf-AD	11..87	CDD:214871
		COG5048	<264..411	CDD:227381	49/148 (33%)
		C2H2 Zn finger	274..294	CDD:275368	5/20 (25%)
		zf-H2C2_2	287..311	CDD:290200	6/23 (26%)
		C2H2 Zn finger	302..322	CDD:275368	6/19 (32%)
		zf-H2C2_2	315..338	CDD:290200	10/22 (45%)
		C2H2 Zn finger	330..350	CDD:275368	4/19 (21%)
		zf-H2C2_2	345..367	CDD:290200	10/21 (48%)
		C2H2 Zn finger	358..378	CDD:275368	7/19 (37%)
		zf-H2C2_2	370..394	CDD:290200	10/23 (43%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000