DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF281 and M1BP

DIOPT Version :9

Sequence 1:	NP_001268222.1	Gene:	ZNF281 / 23528	HGNCID:	13075	Length:	895	Species:	Homo sapiens
Sequence 2:	NP_649825.1	Gene:	M1BP / 41042	FlyBaseID:	FBgn0037621	Length:	418	Species:	Drosophila melanogaster

Alignment Length:	184	Identity:	53/184 - (28%)
Similarity:	78/184 - (42%)	Gaps:	36/184 - (19%)

- Green bases have known domain annotations that are detailed below.

Human   204 DDHHGTEEPKQDTNVKKAK-RPKPESQGIKAKRKPSASSKPSLVGDGEGAILSPSQKPHI----- 262
            ||    |...::..|||.. .|||:.:...|:|:          |.| |..:......||
  Fly   216 DD----EYEHENIVVKKCSLPPKPKVRSDDARRR----------GTG-GVYICEQCGNHIKGRMA 265

Human   263 ---------------CDHCSAAFRSSYHLRRHVLIHTGERPFQCSQCSMGFIQKYLLQRHEKIHS 312
                           |:.|.:.|.::..|:||:..|||||||.|..|...|.......:||:.|:
  Fly   266 FELHCRRHRGDKQFGCELCQSRFCTTSELKRHMRKHTGERPFACKYCGRCFTDYTTRVKHERTHT 330

Human   313 REKPFGCDQCSMKFIQKYHMERHKRTHSGEKPYKCDTCQQYFSRTDRLLKHRRT 366
            .|:|:.|..|...|...|.::.|...||||:.|:|:.|.:.|.....|..|.|:
  Fly   331 NERPYVCGTCGKAFTTGYILKNHMLIHSGERAYRCELCDKSFMLPTHLSTHFRS 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF281	NP_001268222.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..113
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	130..149
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	183..253		14/49 (29%)
		C2H2 Zn finger	263..283	CDD:275368	6/19 (32%)
		zf-H2C2_2	275..300	CDD:316026	13/24 (54%)
		C2H2 Zn finger	291..311	CDD:275368	5/19 (26%)
		zf-H2C2_2	304..328	CDD:316026	8/23 (35%)
		C2H2 Zn finger	319..339	CDD:275368	5/19 (26%)
		zf-H2C2_2	331..356	CDD:316026	9/24 (38%)
		C2H2 Zn finger	347..366	CDD:275368	5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..427
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	638..660
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	778..817
M1BP	NP_649825.1	zf-AD	13..84	CDD:214871
		C2H2 Zn finger	253..273	CDD:275368	2/19 (11%)
		COG5048	276..>331	CDD:227381	19/54 (35%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		zf-H2C2_2	293..317	CDD:290200	12/23 (52%)
		C2H2 Zn finger	309..329	CDD:275368	5/19 (26%)
		zf-H2C2_2	324..346	CDD:290200	8/21 (38%)
		C2H2 Zn finger	337..357	CDD:275368	5/19 (26%)
		zf-H2C2_2	350..372	CDD:290200	8/21 (38%)
		C2H2 Zn finger	365..383	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910