Protein Alignment ACAP2 and acap2

DIOPT Version :9

• Sequence 1: XP_016861535.1
• Gene: ACAP2 / 23527
• HGNCID: 16469
• Length: 848
• Species: Homo sapiens
• Sequence 2: XP_004914426.1
• Gene: acap2 / 100497437
• XenbaseID: XB-GENE-990716
• Length: 783
• Species: Xenopus tropicalis
• Alignment Length: 855
• Identity: 640/855 - (74%)
• Similarity: 701/855 - (81%)
• Gaps: 81/855 - (9%)

Human     1 MKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRD 65
            |||.|||||||||||||||:||:|||||||||:||||||||||.|||.|||||.|||||||||||
 Frog     1 MKMIVDFEECLKDSPRFRASLEDVEGDVAELEMKLDKLVKLCIGMIDAGKAFCAANKQFMNGIRD 65

Human    66 LAQYSSNDAVVETSLTKFSDSLQEMINFHTRQGLPLSLRLECRGMIIALLWESSHLRMILFDQTQ 130
            ||||||.|:|:|:|||||:|||||||.:|.                            :||||.|
 Frog    66 LAQYSSKDSVIESSLTKFADSLQEMIKYHA----------------------------MLFDQAQ 102

Human   131 RSIKAQLQNFVKEDLRKFKDAKKQFEKVSEEKENALVKNAQVQRNKQHEVEEATNILTATRKCFR 195
            ||||.|||.||||||:|||||||||:|||||||||||||||.||.||||||||||||.|||||||
 Frog   103 RSIKTQLQTFVKEDLKKFKDAKKQFDKVSEEKENALVKNAQAQRTKQHEVEEATNILVATRKCFR 167

Human   196 HIALDYVLQINVLQSKRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAA 260
            |||||||||||||||||||||||||||||||||.||||||||||||.|:|||||||||.||.|||
 Frog   168 HIALDYVLQINVLQSKRRSEILKSMLSFMYAHLTFFHQGYDLFSELEPHMKDLGAQLDNLVGDAA 232

Human   261 KEKREMEQKHSTIQQKDFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKTWNRKKPDHIRRWFS 325
            ||||:||.||||||||||:.||:|||.|||..:||||||||||||||||||||||||||.|||||
 Frog   233 KEKRDMEIKHSTIQQKDFADDDTKLECNVDTTSGIVMEGYLFKRASNAFKTWNRKKPDHTRRWFS 297

Human   326 IQNNQLVYQKKFKDNPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKA 390
            |||||||||||||||||||||||||||||.|||||||||||||||||||:|||||:|||||||||
 Frog   298 IQNNQLVYQKKFKDNPTVVVEDLRLCTVKPCEDIERRFCFEVVSPTKSCILQADSDKLRQAWIKA 362

Human   391 VQTSIATAYREKGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIPGNASCCDCGLA 455
            |||||||||||||||:||.:||.|.|..|.:|  |:||.|:|||||||||||||||.:||||||:
 Frog   363 VQTSIATAYREKGDEAEKAEKKPSVSITSPES--ETKENLVKGESALQRVQCIPGNTNCCDCGLS 425

Human   456 DPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEK 520
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||:|.:|||.|||
 Frog   426 DPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVMNSIYEARVEK 490

Human   521 MGIKKPQPG-QRQEKEAYIRAKYVERKFVDKYSISLSPPEQQKKFVSKSSEEKRLSISKFGPGDQ 584
            ||::|||.| |||||||||:|||||:|||||||                  :..|.:.|
 Frog   491 MGVRKPQHGCQRQEKEAYIKAKYVEKKFVDKYS------------------DSSLMVYK------ 531

Human   585 VRASAQSSVIAVNSDEARRESLFCPDELDSLFSYFDTSSKLRSIRSNDSGIQQSSDDGRESLPST 649
             |:.:.|....::|:...|                 |.|| .|::|||||||.|::..||.|..|
 Frog   532 -RSPSLSKADRLSSEPLTR-----------------TPSK-SSVKSNDSGIQFSAEVSREGLAVT 577

Human   650 VSANSLYEPEGE----RQDSSMF--LDSKHLNPGLQLYRASYEKNLPKMAEALAHGADVNWANSE 708
            .|:|||::.:||    :||||.|  |:.|.|.||.||::||||.|||.|||||||||:|||.|::
 Frog   578 ASSNSLFDQDGEKKDDKQDSSAFQELNVKKLLPGPQLFQASYEGNLPGMAEALAHGAEVNWVNTK 642

Human   709 ENKATPLIQAVLGGSLVTCEFLLQNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRGANQHAT 773
            .|.||||||||.||||||||||||||||||.||::|||||||||:|||||||||||||||||||:
 Frog   643 GNNATPLIQAVHGGSLVTCEFLLQNGANVNNRDIKGRGPLHHATLLGHTGQVCLFLKRGANQHAS 707

Human   774 DEEGKDPLSIAVEAANADIVTLLRLARMNEEMRESEGLYGQPGDETYQDIFRDFSQMASNNPEKL 838
            ||:|||||:||::||||||||||||||||||||||||||||||||||||||||||.|||||||||
 Frog   708 DEDGKDPLTIAIDAANADIVTLLRLARMNEEMRESEGLYGQPGDETYQDIFRDFSHMASNNPEKL 772

Human   839 NRF-QQDSQK 847
            ||| |.||.|
 Frog   773 NRFHQSDSPK 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACAP2	XP_016861535.1	None
acap2	XP_004914426.1	BAR_ACAP2	18..217	CDD:153322	173/226 (77%)
		PH_ACAP	269..372	CDD:270070	98/102 (96%)
		ArfGap_ACAP2	404..519	CDD:350076	101/114 (89%)
		Ank_2	614..708	CDD:372319	78/93 (84%)
		ANK repeat	614..640	CDD:293786	20/25 (80%)
		ANK repeat	642..675	CDD:293786	27/32 (84%)
		ANK repeat	677..708	CDD:293786	28/30 (93%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	411	1.000	Domainoid score	I5670
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H8182
Inparanoid	1	1.050	1233	1.000	Inparanoid score	I2136
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D124295at33208
OrthoFinder	1	1.000	-	-		FOG0000653
OrthoInspector	1	1.000	-	-		oto153099
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R258
SonicParanoid	1	1.000	-	-		X412
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.090