DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KAT6B and mof

DIOPT Version :9

Sequence 1:NP_001357065.1 Gene:KAT6B / 23522 HGNCID:17582 Length:2073 Species:Homo sapiens
Sequence 2:NP_511051.1 Gene:mof / 31518 FlyBaseID:FBgn0014340 Length:827 Species:Drosophila melanogaster


Alignment Length:691 Identity:202/691 - (29%)
Similarity:309/691 - (44%) Gaps:116/691 - (16%)


- Green bases have known domain annotations that are detailed below.


Human   357 TSDEGS---------MNAFTGRGS-----------PGRGQKTKVCTTPSSGHAASGKDSSSRLAV 401
            |.||.|         :|.: |.||           |.....|:|.|.|:..|....:.....||.
  Fly   181 TEDEPSSDTVICVADINPY-GSGSNIDDFVMDPDAPPNAIITEVVTIPAPLHLKGTQQLGLPLAA 244

Human   402 -TDPTRPGATTKITTTSTYISASTLKVNKKTKGLIDGLTKFFTPSPDGRRSRGEIIDFSKHYRPR 465
             ..|..|.|..::..|..                        :|:.||...  ..:..|.:.|.|
  Fly   245 PPPPPPPPAAEQVPETPA------------------------SPTDDGEEP--PAVYLSPYIRSR 283

Human   466 KKVSQKQSCTSHVLATGTTQKLKPPPS-SLPPPTPISGQSPSSQKSSTATSSPSPQSSSSQCSVP 529
            ..........:.:......|:..|||: .||..|.:|....:....|:.|||........:....
  Fly   284 YMQESTPGLPTRLAPRDPRQRNMPPPAVVLPIQTVLSANVEAISDDSSETSSSDDDEEEEEDEDD 348

Human   530 SLSSLTTNSQLKALFDGLSHIYTTQGQSRKKGHPSYAPPKRMRRKTELSSTAKSKAHFFGKRD-- 592
            :|:              :.|..|::......|.|       :.:|.::|.. ..|.:|..:.|  
  Fly   349 ALT--------------MEHDNTSRETVITTGDP-------LMQKIDISEN-PDKIYFIRREDGT 391

Human   593 ------IRSRFISHSSSSSWGMARGSIFKAIAHF-----KRTTFLKKHRM------LGRLKYKVT 640
                  ::||...::::..         :...|:     :...::.:||:      ||.:.....
  Fly   392 VHRGQVLQSRTTENAAAPD---------EYYVHYVGLNRRLDGWVGRHRISDNADDLGGITVLPA 447

Human   641 PQMGTPSP------------GKGSLTDGRIKPDQDDDTEIKI--NIKQESADVNVIGNKDVVTEE 691
            |.:....|            ...:.:..|.|...:.|..:..  |.:.:.:|..:...:....:|
  Fly   448 PPLAPDQPSTSREMLAQQAAAAAAASSERQKRAANKDYYLSYCENSRYDYSDRKMTRYQKRRYDE 512

Human   692 DLDVFKQAQELSWEKIECESGVEDCG--RYPSVIEFGKYEIQTWYSSPYPQEYARLPKLYLCEFC 754
            ...|.|...||:..:...|...|...  :|...::||.|||.|||.||:|:||.:...||:||:|
  Fly   513 INHVQKSHAELTATQAALEKEHESITKIKYIDKLQFGNYEIDTWYFSPFPEEYGKARTLYVCEYC 577

Human   755 LKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVDGNMSKIYCQNLCLLAKLFLDHKTLYY 819
            ||||:.::....|..:|....||..||||:.::|::||:|....:|||.|||:||||||||.||:
  Fly   578 LKYMRFRSSYAYHLHECDRRRPPGREIYRKGNISIYEVNGKEESLYCQLLCLMAKLFLDHKVLYF 642

Human   820 DVEPFLFYVLTKNDEKGCHLVGYFSKEKLCQQKYNVSCIMIMPQHQRQGFGRFLIDFSYLLSRRE 884
            |::|||||:|.:.|::|.|:||||||||...:.|||:||:::|.|||:|||:.||.|||.|||:|
  Fly   643 DMDPFLFYILCETDKEGSHIVGYFSKEKKSLENYNVACILVLPPHQRKGFGKLLIAFSYELSRKE 707

Human   885 GQAGSPEKPLSDLGRLSYLAYWKSVILEYLYHH-HERHISIKAISRATGMCPHDIATTLQHLHMI 948
            |..|||||||||||||||.:||...:||.:... ....|:||.:|..:|:...||..|||.:.||
  Fly   708 GVIGSPEKPLSDLGRLSYRSYWAYTLLELMKTRCAPEQITIKELSEMSGITHDDIIYTLQSMKMI 772

Human   949 DKRDGRFVIIRREKLILSHMEKLKTCSRANELDPDSLRWTP 989
            ....|:.||....|.|..|::..:.......:|.|.|.|:|
  Fly   773 KYWKGQNVICVTSKTIQDHLQLPQFKQPKLTIDTDYLVWSP 813

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KAT6BNP_001357065.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 72..97
H15 113..167 CDD:197772
PHD1_MOZ_MORF 212..269 CDD:277090
PHD2_KAT6A_6B 271..317 CDD:277002
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 360..409 16/69 (23%)
Negatively regulates HAT activity 361..717 66/410 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 442..531 18/89 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 553..583 4/29 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 639..663 4/35 (11%)
Catalytic 718..1008 133/273 (49%)
PLN00104 <721..989 CDD:215056 131/268 (49%)
Interaction with BRPF1. /evidence=ECO:0000269|PubMed:18794358 752..1008 116/239 (49%)
Acetyl-CoA binding. /evidence=ECO:0000250|UniProtKB:Q92794 856..860 2/3 (67%)
Acetyl-CoA binding. /evidence=ECO:0000250|UniProtKB:Q92794 865..871 4/5 (80%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1022..1452
BASP1 1435..>1564 CDD:310221
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1484..1538
Interaction with RUNX1 and RUNX2. /evidence=ECO:0000269|PubMed:11965546 1560..2073
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1580..1619
mofNP_511051.1 Tudor-knot 382..432 CDD:288553 6/58 (10%)
NAT_SF 528..813 CDD:302625 134/284 (47%)
MOZ_SAS 599..778 CDD:280097 97/178 (54%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5027
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D629545at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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