DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MTREX and Mtr4

DIOPT Version :9

Sequence 1:	NP_056175.3	Gene:	MTREX / 23517	HGNCID:	18734	Length:	1042	Species:	Homo sapiens
Sequence 2:	NP_524929.1	Gene:	Mtr4 / 48782	FlyBaseID:	FBgn0001986	Length:	1055	Species:	Drosophila melanogaster

Alignment Length:	1069	Identity:	668/1069 - (62%)
Similarity:	821/1069 - (76%)	Gaps:	50/1069 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     7 DELFSVFEGDSTTAA---GTKKDKEKDKGKWKGPPGSADKAG--KRFDGKLQS-ESTNN----GK 61
            :|||..|  |..|.:   .....:||..|      .||.|.|  ::.||...| |:|::    |.
  Fly     4 EELFDCF--DEVTPSVPPPALNQEEKPSG------SSASKKGNKRQADGTTASKEATSSKGAEGD 60

Human    62 NKRDVDFEGTDEPIFGKKPRIEES-------------------ITEDLSLADLMPRVKVQSVETV 107
            :|.||    |:||.  |:.:.|.|                   |.:..:|..|..|:....::..
  Fly    61 DKGDV----TEEPT--KRLKQEASTVAVDDDNNADDEPTRTLDIDDSATLEALRTRIVTHLLDAP 119

Human   108 EGCTHEVALPAEEDYLPLKPRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAE 172
            :.||||||...:::|:||||..|..||||||:||.|||:||.|:||:|||||||||||||||.||
  Fly   120 KSCTHEVAAHPDQEYIPLKPFSGVPAKEYPFVLDPFQRQAILCIDNSQSVLVSAHTSAGKTVVAE 184

Human   173 YAIALALREKQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLY 237
            ||||.:|..|||||:|:|||||||||:||..:||:||||:||||||||:||||:|||||||:|||
  Fly   185 YAIAKSLAAKQRVIYTTPIKALSNQKFREFTDEFKDVGLVTGDVTINPSASCLIMTTEILRNMLY 249

Human   238 RGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQFAEWICHLHKQ 302
            ||||:||||.||:|||||||||.|||||||||:|||||||.|||||||||||||||||:||||||
  Fly   250 RGSEIMREVGWVVFDEIHYMRDKERGVVWEETLILLPDNVRYVFLSATIPNARQFAEWVCHLHKQ 314

Human   303 PCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVLRDAGDLAKGDQKGRKGG 367
            ||||:||||||||||||||||||||:||:|||.|.|:||||.|||.||.:||:..|||||||.||
  Fly   315 PCHVVYTDYRPTPLQHYIFPAGGDGIHLIVDEKGQFKEDNFTTAMAVLANAGEAGKGDQKGRHGG 379

Human   368 TK----GPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKKMVEEVFSNAI 428
            .|    |.:|:||||||||||||.|||||||||||||.||:||.||||||.:|||:|:|||:||:
  Fly   380 IKGTNAGQTNIFKIVKMIMERNFAPVIIFSFSKKDCEIYAMQMAKLDFNTPDEKKLVDEVFNNAM 444

Human   429 DCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPA 493
            |.|::||::|||||:|||||:||||||||||||||||||||||.||||||||||||||||:||||
  Fly   445 DVLTEEDRRLPQVENVLPLLRRGIGIHHGGLLPILKETIEILFGEGLIKALFATETFAMGLNMPA 509

Human   494 RTVLFTNARKFDGKDFRWISSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADP 558
            ||||||..||||||.||||||||||||:|||||||:||:||||||:|||:||.:|:.:::|.|||
  Fly   510 RTVLFTAPRKFDGKKFRWISSGEYIQMAGRAGRRGLDDKGIVILMIDEKVSPAVGRDIVQGKADP 574

Human   559 LNSAFHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPGVVEKVKNSEEQYNKIVIPNEESV 623
            :|||||||||||||||||||||||||||:||||||:..|:||:.::|:....:.||:.|.:|.::
  Fly   575 INSAFHLTYNMVLNLLRVEEINPEYMLERSFYQFQNQAALPGLHDQVEQKTLELNKLTIKDEHNI 639

Human   624 VIYYKIRQQLAKLGKEIEEYIHKPKYCLPFLQPGRLVKVKNEGDDFGWGVVVNFSKKSNVKPNSG 688
            ..|:.||.||.:.||:..::|.||:|.||||||||||||.....::.||:|:||.|:...:.|..
  Fly   640 ASYHHIRSQLDQHGKQFRQWITKPQYLLPFLQPGRLVKVAAGSQEYDWGIVLNFKKQDQSRKNPL 704

Human   689 ELDPLYVVEVLLRCSKESLKNSATEAAKPAKPDEKGEMQVVPVLVHLLSAISSVRLYIPKDLRPV 753
            :.:|...::|||..|:.:.|...||   |.||:|:|.|:||||...|::.|||:|:|.|.|||..
  Fly   705 KAEPSVTIDVLLHVSEAAAKTGDTE---PCKPNERGCMEVVPVAHTLITQISSIRVYFPNDLRSA 766

Human   754 DNRQSVLKSIQEVQKRFPDGIPLLDPIDDMGIQDQGLKKVIQKVEAFEHRMYSHPLHNDPNLETV 818
            |||::|||:|||.:||||.|.|:|:|||||.|:|:..:.::..:..||.|:..||||..|.||.:
  Fly   767 DNRRAVLKTIQEAKKRFPLGPPVLNPIDDMNIKDREFRDIVNTISQFEKRLEEHPLHKSPELERI 831

Human   819 YTLCEKKAQIAIDIKSAKRELKKARTVLQMDELKCRKRVLRRLGFATSSDVIEMKGRVACEISSA 883
            :...:.|..:...::..|.|||.||::|||||||.|||||||:|:....||||.|||||||:|||
  Fly   832 HRRYQDKVTLQKQLQDLKAELKAARSLLQMDELKHRKRVLRRMGYCKPGDVIEFKGRVACELSSA 896

Human   884 DELLLTEMMFNGLFNDLSAEQATALLSCFVFQENSSEMPKLTEQLAGPLRQMQECAKRIAKVSAE 948
            ||||:|||:|||:||||:|.||.|||||||..|.|||..|...:|:||||.||:.|:||||||.|
  Fly   897 DELLMTEMIFNGVFNDLTAPQAVALLSCFVCDEKSSESVKSATELSGPLRSMQDLARRIAKVSTE 961

Human   949 AKLEIDEETYLSSFKPHLMDVVYTWATGATFAHICKMTDVFEGSIIRCMRRLEELLRQMCQAAKA 1013
            .||::|.:||:..|||.|||||..|..|::|..:|||||:||||||||||||||||||||||:|.
  Fly   962 CKLDLDADTYVDKFKPFLMDVVLAWCKGSSFLAVCKMTDIFEGSIIRCMRRLEELLRQMCQASKT 1026

Human  1014 IGNTELENKFAEGITKIKRDIVFAASLYL 1042
            ||||:|||||:|||..:||||||||||||
  Fly  1027 IGNTDLENKFSEGIRLLKRDIVFAASLYL 1055

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTREX	NP_056175.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..74		19/67 (28%)
		Dob10	68..1042	CDD:226947	644/996 (65%)
		DEAD	144..287	CDD:278688	116/142 (82%)
		DEIH box	252..255		2/2 (100%)
		HELICc	374..538	CDD:238034	137/163 (84%)
		rRNA_proc-arch	584..840	CDD:289976	111/255 (44%)
		DSHCT	868..1035	CDD:285374	117/166 (70%)
Mtr4	NP_524929.1	Dob10	91..1055	CDD:226947	638/966 (66%)
		DEAD	154..299	CDD:278688	117/144 (81%)
		HELICc	390..554	CDD:238034	137/163 (84%)
		rRNA_proc-arch	600..853	CDD:289976	111/255 (44%)
		DSHCT	881..1048	CDD:285374	117/166 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158872
Domainoid	1	1.000	249	1.000	Domainoid score	I2140
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6257
Inparanoid	1	1.050	1322	1.000	Inparanoid score	I150
Isobase	1	0.950	-	0	Normalized mean entropy	S388
OMA	1	1.010	-	-		QHG53687
OrthoDB	1	1.010	-	-		D176060at2759
OrthoFinder	1	1.000	-	-		FOG0003580
OrthoInspector	1	1.000	-	-		oto90704
orthoMCL	1	0.900	-	-		OOG6_100340
Panther	1	1.100	-	-	LDO	PTHR12131
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2451
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.720