DRSC/TRiP Functional Genomics Resources

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Protein Alignment SCRIB and scrib

DIOPT Version :10

Sequence 1:NP_874365.3 Gene:SCRIB / 23513 HGNCID:30377 Length:1655 Species:Homo sapiens
Sequence 2:NP_001163746.1 Gene:scrib / 44448 FlyBaseID:FBgn0263289 Length:2585 Species:Drosophila melanogaster


Alignment Length:2240 Identity:739/2240 - (32%)
Similarity:1007/2240 - (44%) Gaps:679/2240 - (30%)


- Green bases have known domain annotations that are detailed below.


Human     1 MLKCIPLWR-CNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKL 64
            |.||||::: |||.||.||||||||..|||||.||||:||||.||||.:|:|||.||||..||||
  Fly     1 MFKCIPIFKGCNRQVEFVDKRHCSLPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRLHRLRKL 65

Human    65 GLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRS 129
            |||||||.||||::.||..||||||||||||:||:.||..::|::||||.||:.:||.||:||::
  Fly    66 GLSDNEIGRLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKN 130

Human   130 LAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLG 194
            |..|.|||:||..||.|.|:|..|.:|||||||||.||.::|.|.||::||||.|::|.||..||
  Fly   131 LTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLG 195

Human   195 ALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLP 259
            .||.|.|||||.|||..||||||.|.:|..||||||||||||.|:.|||.||||.|:||||..||
  Fly   196 YLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALP 260

Human   260 DGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHL 324
            |||.:|.:|:|||:|||||..:.:.:|:|||:.|||||||.|..||.|:|::|||.|||||||.|
  Fly   261 DGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNAL 325

Human   325 EALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKALWLAE 389
            |.||.|||.|..|.|||||||:|..|||||.:.|.||||||:||:|..||::|.:|.|||:||:|
  Fly   326 EYLPLEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQLKAVWLSE 390

Human   390 NQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPPSLEDAGQQGSLSETWSDAPPSRVSVIQFLEAP 454
            ||:||:|.||.:.||.|||:||:|||||||....:..|....|.||.:.:..||| :|::|    
  Fly   391 NQSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPARDLESDSEPFEEREPSR-TVVKF---- 450

Human   455 IGDEDAEEAAAEKR-GLQRRATPHPSEL--KVMKRSIEGRRSE----ACPCQPDSGSPLPAE--E 510
                 :|||..||. ...|:.||||.:|  |..|..:|..|:|    ......::|:.| ||  .
  Fly   451 -----SEEATQEKETPFVRQNTPHPKDLKAKAQKLKVERSRNEEHANLVTLPEENGTKL-AETPT 509

Human   511 EKRLSAES-------------GLSEDS-------RPSASTVSEAEPEGPSAEAQGGSQ------- 548
            |.|..|.:             |::...       .|:.:||:   |.|    .||||:       
  Fly   510 ETRTIANNHQQQPHPVQQPIVGVNSKQPVVVGVVTPTTTTVA---PTG----VQGGSEGASSTAN 567

Human   549 -----------QEATTAGGEEDAEEDYQEPTVHFAEDALLPGDDREI---EEGQPEAPWTLPGGR 599
                       :.|.|.||.::.::|.::      ||..  ..||.:   .||:.:..:..|   
  Fly   568 NVKAATAAVVAELAATVGGSDEVQDDDEQ------EDEF--ESDRRVGFQVEGEDDDFYKRP--- 621

Human   600 QRLIRKDTPHYKKHFKISKLPQPEAVVALLQGMQPDGEGPVAPGGWHNGPHAPWAPRAQKEEEEE 664
            .:|.|:||||:.|:.::..|...:|...|...:.........|      .|:.........||||
  Fly   622 PKLHRRDTPHHLKNKRVQHLTDKQASEILANALASQERNDTTP------QHSLSGKVTSPIEEEE 680

Human   665 EEGSPQEEEEEEEEE---------NRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPA 720
            :....||:::::::.         :..:..||||:.::.:|                    :...
  Fly   681 QLEVEQEQQQQQQQHPFDSSLSPISAGKTAEASTDPDNLDG--------------------VTEL 725

Human   721 RIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNG 785
            |:|:.|  :.|.|...|||:||||||||||:||||:|||||||:|.|||..||::||||:::|||
  Fly   726 RLEQYE--IHIERTAAGLGLSIAGGKGSTPFKGDDDGIFISRVTEAGPADLAGLKVGDKVIKVNG 788

Human   786 VALQGAEHHEAVEALRGAGTAVQMRVWRE--RMV-EP---------ENAVTITPL---------- 828
            :.:..|:|::||:.|:..|..:.:.|.||  |:: .|         :.:|...||          
  Fly   789 IVVVDADHYQAVQVLKACGAVLVLVVQREVTRLIGHPVFSEDGSVSQISVETRPLVADAPPAASI 853

Human   829 ------------------------RPEDDYSPRERRGGGL-------------------RLPLLP 850
                                    :|....:|.....|.:                   .|.|..
  Fly   854 SHERYIPAPIEIVPQQQHLQQQQQQPIQQVAPTHSYSGNVFATPTAAQTVQPAVSAAPNGLLLNG 918

Human   851 PESPGPLRQRHVACLARSE--RGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGD 913
            .|:|....|.|.. |.|.:  :||||||||||||.|::....|||:|||.|||.|:|.|.:.|||
  Fly   919 REAPLSYIQLHTT-LIRDQIGQGLGFSIAGGKGSPPFKDDCDGIFISRITEGGLAYRDGKIMVGD 982

Human   914 RVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPP---------------------- 956
            ||::|||.|:|||.||.||:.||.....:.|:|:||..|||.|                      
  Fly   983 RVMAINGNDMTEAHHDAAVACLTEPQRFVRLVLQREYRGPLEPPTSPRSPAVLNSLSPSGYLANR 1047

Human   957 -----------------------SPLPHSSPP-------------------TAAVATTSITTATP 979
                                   :|.|..:.|                   |||.||...:|..|
  Fly  1048 PANFSRSVVEVEQPYKYNTLATTTPTPKPTVPASISNNNNTLPSSKTNGFATAAAATIDSSTGQP 1112

Human   980 ----------------------------------------------------------------- 979
                                                                             
  Fly  1113 VPAPRRTNSVPMGDGDIGAGSTTSGDSGEAQPSSLRPLTSDDFQAMIPAHFLSGGSQHQVHVARP 1177

Human   980 ---GV-----------PGLPSL--APSLLAAALE---------------------GPYPVEEIRL 1007
               ||           |.||..  ||:.|....|                     .|...||:.|
  Fly  1178 NEVGVSAVTVNVNKPQPDLPMFPAAPTELGRVTETITKSTFTETVMTRITDNQLAEPLISEEVVL 1242

Human  1008 PRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATH 1071
            |:..|.||.||:||:|||..|||.:|||:|||.::|.|:|::.| ||:|||||.||..||..|||
  Fly  1243 PKNQGSLGFSIIGGTDHSCVPFGTREPGIFISHIVPGGIASKCGKLRMGDRILKVNEADVSKATH 1307

Human  1072 QEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFI 1136
            |:||..||:|..|:.|.::.||.|||.:|:.:.||.|||||:.|:||..|..|||.||:|||:|:
  Fly  1308 QDAVLELLKPGDEIKLTIQHDPLPPGFQEVLLSKAEGERLGMHIKGGLNGQRGNPADPSDEGVFV 1372

Human  1137 SKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEAST----- 1196
            ||::..|||.|||||:||:||||||..||||.:|.:||.:||:.|:.:.::||.|::.|.     
  Fly  1373 SKINSVGAARRDGRLKVGMRLLEVNGHSLLGASHQDAVNVLRNAGNEIQLVVCKGYDKSNLIHSI 1437

Human  1197 DAALEVSPGVIANPFAAGIGHRNS-----------LESISSIDRE-------------------L 1231
            ..|..:|.|..::...:|...:.|           .:|:||:|.|                   .
  Fly  1438 GQAGGMSTGFNSSASCSGGSRQGSRASETGSELSQSQSVSSLDHEEDERLRQDFDVFASQKPDAQ 1502

Human  1232 SPEGP-----------GKEKELP-------------------------------------GQTLH 1248
            .|.||           |.....|                                     .|..|
  Fly  1503 QPTGPSVLAAAAAMVHGASSPTPPAATSNITPLPTAAAVASADLTAPDTPATQTVALIHAEQQAH 1567

Human  1249 WGPEATEAAGRGLQ--------------------PLK------------------LDYRALAAVP 1275
            ...:.|:.|..|.:                    |.|                  :....|...|
  Fly  1568 QQQQQTQLAPLGQEKSTQEKVLEIVRAADAFTTVPPKSPSEHHEQDKIQKTTTVVISKHTLDTNP 1632

Human  1276 SAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPP-SPDELPANVKQAYRAFAAVPTSHPPEDAPAQ 1339
            :..:....|...||.:.|.|..:||...|.|.| |...|||...|......:.......|.....
  Fly  1633 TTPTTPAAPLSIAGAESANSAGAPSPAVPASTPGSAPVLPAVAVQTQTQTTSTEKDEEEESQLQS 1697

Human  1340 PPT---------------PGPAASPEQLSFRERQKYFE--LEVRVPQAEGPPKRVSLVGADDLRK 1387
            .|.               |.|...|:.:|  :::::||  :|.:....:...|..|.:..|::.|
  Fly  1698 TPASRDGAEEQQEEVRAKPTPTKVPKSVS--DKKRFFESAMEDQHKPTQKTDKVFSFLSKDEVEK 1760

Human  1388 MQEEEARKL----QQKRAQML--------REAA---------------------EAGAEARLALD 1419
            :::||.||:    :.|.:::|        ::||                     |.|.....::|
  Fly  1761 LRQEEERKIATLRRDKNSRLLDAANDNIDKDAAQQRTKSNSNSSSGDDNDDSDQEEGIARGDSVD 1825

Human  1420 GETLGE-EEQED-------------------------EQPPWASPSPTS---------------- 1442
            ...||. ::.||                         :|...:.|:||:                
  Fly  1826 NAALGHFDDAEDMRTAQSLASTMPHAPSKIPKQKLKAKQIESSLPTPTALDPPKPSLLPKPKVKV 1890

Human  1443 ----------------------RQS-----------------PASPPPLGGG-APVRTAKAERR- 1466
                                  :||                 |.||...||. .||||.||||| 
  Fly  1891 VIPPALQQRLKQQQVQQQQQQHQQSQPEEPSIPEEEYHQQPEPDSPSAAGGSRIPVRTLKAERRA 1955

Human  1467 --------------HQERLRVQ-SPEPPAPERALSPAELRALEAEKRALWRAARMKSLEQDALRA 1516
                          :.:||..| ..|.||.....:......:.|||||.|||||::||||.|:.|
  Fly  1956 LTLAARQSGLSVEEYLKRLETQDDKESPASPTTPTGKSRSMINAEKRASWRAARLRSLEQGAVEA 2020

Human  1517 QMVL--------------SRSQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTSTSPGRLPL 1567
            |.|:              ||:.|....:   ||:.......|     ..||.|....|.|   ||
  Fly  2021 QDVIKNMRKMTDDLITHESRASEVETCK---ERIISLELQVP-----ETEDEGKLDDTQP---PL 2074

Human  1568 SGKKFDYRAFAALPSSRPVYDIQSPDFAEELRSLEPSPSPGPQEEDGEVALV--------LLGRP 1624
            ..:..|::.    .......|....||.:|            .||:...::|        |..|.
  Fly  2075 ELEADDFQD----DEDDDDDDDDEDDFEDE------------DEEEDTASIVTVQANNEKLFLRH 2123

Human  1625 SPGAVGPEDVALCSSRRPVRPGRRGLGPVP 1654
            .....||      ||...|..|:..:.|.|
  Fly  2124 DSDTYGP------SSIESVASGKVRIKPTP 2147

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCRIBNP_874365.3 Sufficient for targeting to adherens junction and to inhibit cell proliferation 1..818 404/879 (46%)
leucine-rich repeat 14..37 CDD:275380 18/22 (82%)
LRR_8 36..94 CDD:404697 43/57 (75%)
leucine-rich repeat 38..60 CDD:275380 16/21 (76%)
leucine-rich repeat 61..83 CDD:275380 17/21 (81%)
leucine-rich repeat 84..106 CDD:275380 16/21 (76%)
LRR 87..>396 CDD:443914 195/308 (63%)
leucine-rich repeat 107..129 CDD:275380 13/21 (62%)
leucine-rich repeat 130..152 CDD:275380 12/21 (57%)
leucine-rich repeat 153..175 CDD:275380 14/21 (67%)
leucine-rich repeat 176..198 CDD:275380 12/21 (57%)
leucine-rich repeat 199..221 CDD:275380 16/21 (76%)
leucine-rich repeat 268..290 CDD:275380 11/21 (52%)
leucine-rich repeat 291..313 CDD:275380 12/21 (57%)
leucine-rich repeat 314..336 CDD:275380 16/21 (76%)
leucine-rich repeat 360..381 CDD:275380 12/20 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 417..440 7/22 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 459..606 47/196 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 628..702 14/82 (17%)
Interaction with ARHGEF7. /evidence=ECO:0000269|PubMed:15182672 717..1229 253/761 (33%)
PDZ1_Scribble-like 727..813 CDD:467188 46/85 (54%)
Required for interaction with VIM. /evidence=ECO:0000269|PubMed:19386766 728..1194 241/699 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 827..853 7/78 (9%)
PDZ2_Scribble-like 859..950 CDD:467187 50/92 (54%)
PDZ3_Scribble-like 1003..1091 CDD:467186 49/88 (56%)
PDZ4_Scribble-like 1095..1192 CDD:467185 54/96 (56%)
Interaction with tick-borne encephalitis virus RNA-directed RNA polymerase NS5. /evidence=ECO:0000269|PubMed:18042258 1105..1117 8/11 (73%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1227..1246 7/85 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1277..1489 69/360 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1520..1568 12/61 (20%)
AbLIM_anchor 1555..>1630 CDD:465046 15/82 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1622..1655 9/33 (27%)
scribNP_001163746.1 leucine-rich repeat 18..38 CDD:275380 16/19 (84%)
LRR_8 37..95 CDD:404697 43/57 (75%)
leucine-rich repeat 39..61 CDD:275380 16/21 (76%)
leucine-rich repeat 62..84 CDD:275380 17/21 (81%)
LRR 67..408 CDD:443914 215/340 (63%)
leucine-rich repeat 85..107 CDD:275380 16/21 (76%)
leucine-rich repeat 108..130 CDD:275380 13/21 (62%)
leucine-rich repeat 131..153 CDD:275380 12/21 (57%)
leucine-rich repeat 154..176 CDD:275380 14/21 (67%)
leucine-rich repeat 177..199 CDD:275380 12/21 (57%)
leucine-rich repeat 200..222 CDD:275380 16/21 (76%)
leucine-rich repeat 223..245 CDD:275380 16/21 (76%)
leucine-rich repeat 269..289 CDD:275380 10/19 (53%)
leucine-rich repeat 292..314 CDD:275380 12/21 (57%)
leucine-rich repeat 315..337 CDD:275380 16/21 (76%)
leucine-rich repeat 361..382 CDD:275380 12/20 (60%)
PDZ1_Scribble-like 730..816 CDD:467188 47/87 (54%)
PDZ2_Scribble-like 927..1019 CDD:467187 50/92 (54%)
PDZ3_Scribble-like 1238..1327 CDD:467186 49/88 (56%)
PDZ4_Scribble-like 1331..1428 CDD:467185 54/96 (56%)

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