DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCRIB and scrib

DIOPT Version :9

Sequence 1:	NP_874365.3	Gene:	SCRIB / 23513	HGNCID:	30377	Length:	1655	Species:	Homo sapiens
Sequence 2:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster

Alignment Length:	2240	Identity:	739/2240 - (32%)
Similarity:	1007/2240 - (44%)	Gaps:	679/2240 - (30%)

- Green bases have known domain annotations that are detailed below.

Human     1 MLKCIPLWR-CNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKL 64
            |.||||::: |||.||.||||||||..|||||.||||:||||.||||.:|:|||.||||..||||
  Fly     1 MFKCIPIFKGCNRQVEFVDKRHCSLPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRLHRLRKL 65

Human    65 GLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRS 129
            |||||||.||||::.||..||||||||||||:||:.||..::|::||||.||:.:||.||:||::
  Fly    66 GLSDNEIGRLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKN 130

Human   130 LAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLG 194
            |..|.|||:||..||.|.|:|..|.:|||||||||.||.::|.|.||::||||.|::|.||..||
  Fly   131 LTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLG 195

Human   195 ALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLP 259
            .||.|.|||||.|||..||||||.|.:|..||||||||||||.|:.|||.||||.|:||||..||
  Fly   196 YLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALP 260

Human   260 DGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHL 324
            |||.:|.:|:|||:|||||..:.:.:|:|||:.|||||||.|..||.|:|::|||.|||||||.|
  Fly   261 DGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNAL 325

Human   325 EALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKALWLAE 389
            |.||.|||.|..|.|||||||:|..|||||.:.|.||||||:||:|..||::|.:|.|||:||:|
  Fly   326 EYLPLEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQLKAVWLSE 390

Human   390 NQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPPSLEDAGQQGSLSETWSDAPPSRVSVIQFLEAP 454
            ||:||:|.||.:.||.|||:||:|||||||....:..|....|.||.:.:..||| :|::|
  Fly   391 NQSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPARDLESDSEPFEEREPSR-TVVKF---- 450

Human   455 IGDEDAEEAAAEKR-GLQRRATPHPSEL--KVMKRSIEGRRSE----ACPCQPDSGSPLPAE--E 510
                 :|||..||. ...|:.||||.:|  |..|..:|..|:|    ......::|:.| ||  .
  Fly   451 -----SEEATQEKETPFVRQNTPHPKDLKAKAQKLKVERSRNEEHANLVTLPEENGTKL-AETPT 509

Human   511 EKRLSAES-------------GLSEDS-------RPSASTVSEAEPEGPSAEAQGGSQ------- 548
            |.|..|.:             |::...       .|:.:||:   |.|    .||||:
  Fly   510 ETRTIANNHQQQPHPVQQPIVGVNSKQPVVVGVVTPTTTTVA---PTG----VQGGSEGASSTAN 567

Human   549 -----------QEATTAGGEEDAEEDYQEPTVHFAEDALLPGDDREI---EEGQPEAPWTLPGGR 599
                       :.|.|.||.::.::|.::      ||..  ..||.:   .||:.:..:..|
  Fly   568 NVKAATAAVVAELAATVGGSDEVQDDDEQ------EDEF--ESDRRVGFQVEGEDDDFYKRP--- 621

Human   600 QRLIRKDTPHYKKHFKISKLPQPEAVVALLQGMQPDGEGPVAPGGWHNGPHAPWAPRAQKEEEEE 664
            .:|.|:||||:.|:.::..|...:|...|...:.........|      .|:.........||||
  Fly   622 PKLHRRDTPHHLKNKRVQHLTDKQASEILANALASQERNDTTP------QHSLSGKVTSPIEEEE 680

Human   665 EEGSPQEEEEEEEEE---------NRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPA 720
            :....||:::::::.         :..:..||||:.::.:|                    :...
  Fly   681 QLEVEQEQQQQQQQHPFDSSLSPISAGKTAEASTDPDNLDG--------------------VTEL 725

Human   721 RIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNG 785
            |:|:.|  :.|.|...|||:||||||||||:||||:|||||||:|.|||..||::||||:::|||
  Fly   726 RLEQYE--IHIERTAAGLGLSIAGGKGSTPFKGDDDGIFISRVTEAGPADLAGLKVGDKVIKVNG 788

Human   786 VALQGAEHHEAVEALRGAGTAVQMRVWRE--RMV-EP---------ENAVTITPL---------- 828
            :.:..|:|::||:.|:..|..:.:.|.||  |:: .|         :.:|...||
  Fly   789 IVVVDADHYQAVQVLKACGAVLVLVVQREVTRLIGHPVFSEDGSVSQISVETRPLVADAPPAASI 853

Human   829 ------------------------RPEDDYSPRERRGGGL-------------------RLPLLP 850
                                    :|....:|.....|.:                   .|.|..
  Fly   854 SHERYIPAPIEIVPQQQHLQQQQQQPIQQVAPTHSYSGNVFATPTAAQTVQPAVSAAPNGLLLNG 918

Human   851 PESPGPLRQRHVACLARSE--RGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGD 913
            .|:|....|.|.. |.|.:  :||||||||||||.|::....|||:|||.|||.|:|.|.:.|||
  Fly   919 REAPLSYIQLHTT-LIRDQIGQGLGFSIAGGKGSPPFKDDCDGIFISRITEGGLAYRDGKIMVGD 982

Human   914 RVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPP---------------------- 956
            ||::|||.|:|||.||.||:.||.....:.|:|:||..|||.|
  Fly   983 RVMAINGNDMTEAHHDAAVACLTEPQRFVRLVLQREYRGPLEPPTSPRSPAVLNSLSPSGYLANR 1047

Human   957 -----------------------SPLPHSSPP-------------------TAAVATTSITTATP 979
                                   :|.|..:.|                   |||.||...:|..|
  Fly  1048 PANFSRSVVEVEQPYKYNTLATTTPTPKPTVPASISNNNNTLPSSKTNGFATAAAATIDSSTGQP 1112

Human   980 ----------------------------------------------------------------- 979

  Fly  1113 VPAPRRTNSVPMGDGDIGAGSTTSGDSGEAQPSSLRPLTSDDFQAMIPAHFLSGGSQHQVHVARP 1177

Human   980 ---GV-----------PGLPSL--APSLLAAALE---------------------GPYPVEEIRL 1007
               ||           |.||..  ||:.|....|                     .|...||:.|
  Fly  1178 NEVGVSAVTVNVNKPQPDLPMFPAAPTELGRVTETITKSTFTETVMTRITDNQLAEPLISEEVVL 1242

Human  1008 PRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATH 1071
            |:..|.||.||:||:|||..|||.:|||:|||.::|.|:|::.| ||:|||||.||..||..|||
  Fly  1243 PKNQGSLGFSIIGGTDHSCVPFGTREPGIFISHIVPGGIASKCGKLRMGDRILKVNEADVSKATH 1307

Human  1072 QEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFI 1136
            |:||..||:|..|:.|.::.||.|||.:|:.:.||.|||||:.|:||..|..|||.||:|||:|:
  Fly  1308 QDAVLELLKPGDEIKLTIQHDPLPPGFQEVLLSKAEGERLGMHIKGGLNGQRGNPADPSDEGVFV 1372

Human  1137 SKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEAST----- 1196
            ||::..|||.|||||:||:||||||..||||.:|.:||.:||:.|:.:.::||.|::.|.
  Fly  1373 SKINSVGAARRDGRLKVGMRLLEVNGHSLLGASHQDAVNVLRNAGNEIQLVVCKGYDKSNLIHSI 1437

Human  1197 DAALEVSPGVIANPFAAGIGHRNS-----------LESISSIDRE-------------------L 1231
            ..|..:|.|..::...:|...:.|           .:|:||:|.|                   .
  Fly  1438 GQAGGMSTGFNSSASCSGGSRQGSRASETGSELSQSQSVSSLDHEEDERLRQDFDVFASQKPDAQ 1502

Human  1232 SPEGP-----------GKEKELP-------------------------------------GQTLH 1248
            .|.||           |.....|                                     .|..|
  Fly  1503 QPTGPSVLAAAAAMVHGASSPTPPAATSNITPLPTAAAVASADLTAPDTPATQTVALIHAEQQAH 1567

Human  1249 WGPEATEAAGRGLQ--------------------PLK------------------LDYRALAAVP 1275
            ...:.|:.|..|.:                    |.|                  :....|...|
  Fly  1568 QQQQQTQLAPLGQEKSTQEKVLEIVRAADAFTTVPPKSPSEHHEQDKIQKTTTVVISKHTLDTNP 1632

Human  1276 SAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPP-SPDELPANVKQAYRAFAAVPTSHPPEDAPAQ 1339
            :..:....|...||.:.|.|..:||...|.|.| |...|||...|......:.......|.....
  Fly  1633 TTPTTPAAPLSIAGAESANSAGAPSPAVPASTPGSAPVLPAVAVQTQTQTTSTEKDEEEESQLQS 1697

Human  1340 PPT---------------PGPAASPEQLSFRERQKYFE--LEVRVPQAEGPPKRVSLVGADDLRK 1387
            .|.               |.|...|:.:|  :::::||  :|.:....:...|..|.:..|::.|
  Fly  1698 TPASRDGAEEQQEEVRAKPTPTKVPKSVS--DKKRFFESAMEDQHKPTQKTDKVFSFLSKDEVEK 1760

Human  1388 MQEEEARKL----QQKRAQML--------REAA---------------------EAGAEARLALD 1419
            :::||.||:    :.|.:::|        ::||                     |.|.....::|
  Fly  1761 LRQEEERKIATLRRDKNSRLLDAANDNIDKDAAQQRTKSNSNSSSGDDNDDSDQEEGIARGDSVD 1825

Human  1420 GETLGE-EEQED-------------------------EQPPWASPSPTS---------------- 1442
            ...||. ::.||                         :|...:.|:||:
  Fly  1826 NAALGHFDDAEDMRTAQSLASTMPHAPSKIPKQKLKAKQIESSLPTPTALDPPKPSLLPKPKVKV 1890

Human  1443 ----------------------RQS-----------------PASPPPLGGG-APVRTAKAERR- 1466
                                  :||                 |.||...||. .||||.|||||
  Fly  1891 VIPPALQQRLKQQQVQQQQQQHQQSQPEEPSIPEEEYHQQPEPDSPSAAGGSRIPVRTLKAERRA 1955

Human  1467 --------------HQERLRVQ-SPEPPAPERALSPAELRALEAEKRALWRAARMKSLEQDALRA 1516
                          :.:||..| ..|.||.....:......:.|||||.|||||::||||.|:.|
  Fly  1956 LTLAARQSGLSVEEYLKRLETQDDKESPASPTTPTGKSRSMINAEKRASWRAARLRSLEQGAVEA 2020

Human  1517 QMVL--------------SRSQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTSTSPGRLPL 1567
            |.|:              ||:.|....:   ||:.......|     ..||.|....|.|   ||
  Fly  2021 QDVIKNMRKMTDDLITHESRASEVETCK---ERIISLELQVP-----ETEDEGKLDDTQP---PL 2074

Human  1568 SGKKFDYRAFAALPSSRPVYDIQSPDFAEELRSLEPSPSPGPQEEDGEVALV--------LLGRP 1624
            ..:..|::.    .......|....||.:|            .||:...::|        |..|.
  Fly  2075 ELEADDFQD----DEDDDDDDDDEDDFEDE------------DEEEDTASIVTVQANNEKLFLRH 2123

Human  1625 SPGAVGPEDVALCSSRRPVRPGRRGLGPVP 1654
            .....||      ||...|..|:..:.|.|
  Fly  2124 DSDTYGP------SSIESVASGKVRIKPTP 2147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCRIB	NP_874365.3	Sufficient for targeting to adherens junction and to inhibit cell proliferation	1..818		404/879 (46%)
		LRR_RI	12..232	CDD:238064	145/219 (66%)
		leucine-rich repeat	14..37	CDD:275380	18/22 (82%)
		leucine-rich repeat	38..60	CDD:275380	16/21 (76%)
		LRR	39..401	CDD:227223	233/361 (65%)
		leucine-rich repeat	61..83	CDD:275380	17/21 (81%)
		leucine-rich repeat	84..106	CDD:275380	16/21 (76%)
		leucine-rich repeat	107..129	CDD:275380	13/21 (62%)
		leucine-rich repeat	130..152	CDD:275380	12/21 (57%)
		leucine-rich repeat	153..175	CDD:275380	14/21 (67%)
		leucine-rich repeat	176..198	CDD:275380	12/21 (57%)
		leucine-rich repeat	199..221	CDD:275380	16/21 (76%)
		leucine-rich repeat	268..290	CDD:275380	11/21 (52%)
		leucine-rich repeat	291..313	CDD:275380	12/21 (57%)
		leucine-rich repeat	314..336	CDD:275380	16/21 (76%)
		leucine-rich repeat	360..381	CDD:275380	12/20 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	417..440		7/22 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..604		46/194 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	633..702		13/77 (17%)
		Interaction with ARHGEF7. /evidence=ECO:0000269\|PubMed:15182672	717..1229		253/761 (33%)
		PDZ	725..813	CDD:214570	47/87 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	827..853		7/78 (9%)
		PDZ_signaling	860..947	CDD:238492	47/88 (53%)
		PDZ_signaling	1002..1090	CDD:238492	49/88 (56%)
		PDZ_signaling	1098..1189	CDD:238492	49/90 (54%)
		Interaction with tick-borne encephalitis virus RNA-directed RNA polymerase NS5. /evidence=ECO:0000269\|PubMed:18042258	1105..1117		8/11 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1227..1246		7/85 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1277..1489		69/360 (19%)
		AbLIM_anchor	1555..>1593	CDD:292800	7/37 (19%)
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	179/269 (67%)
		leucine-rich repeat	18..38	CDD:275380	16/19 (84%)
		LRR_8	37..95	CDD:290566	43/57 (75%)
		leucine-rich repeat	39..61	CDD:275380	16/21 (76%)
		leucine-rich repeat	62..84	CDD:275380	17/21 (81%)
		LRR_8	84..138	CDD:290566	32/53 (60%)
		leucine-rich repeat	85..107	CDD:275380	16/21 (76%)
		leucine-rich repeat	108..130	CDD:275380	13/21 (62%)
		LRR_8	129..187	CDD:290566	33/57 (58%)
		leucine-rich repeat	131..153	CDD:275380	12/21 (57%)
		leucine-rich repeat	154..176	CDD:275380	14/21 (67%)
		leucine-rich repeat	177..199	CDD:275380	12/21 (57%)
		LRR_8	198..256	CDD:290566	41/57 (72%)
		leucine-rich repeat	200..222	CDD:275380	16/21 (76%)
		leucine-rich repeat	223..245	CDD:275380	16/21 (76%)
		LRR_8	267..325	CDD:290566	35/57 (61%)
		leucine-rich repeat	269..289	CDD:275380	10/19 (53%)
		leucine-rich repeat	292..314	CDD:275380	12/21 (57%)
		leucine-rich repeat	315..337	CDD:275380	16/21 (76%)
		LRR_4	337..375	CDD:289563	24/37 (65%)
		leucine-rich repeat	361..382	CDD:275380	12/20 (60%)
		PDZ	728..816	CDD:214570	48/89 (54%)
		PDZ_signaling	931..1016	CDD:238492	46/85 (54%)
		PDZ	1239..1329	CDD:214570	48/89 (54%)
		PDZ_signaling	1336..1425	CDD:238492	49/88 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2103
eggNOG	1	0.900	-	-		E33208_3BA7S
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	781	1.000	Inparanoid score	I527
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48681
OrthoDB	1	1.010	-	-		D148064at33208
OrthoFinder	1	1.000	-	-		FOG0005473
OrthoInspector	1	1.000	-	-		otm42158
orthoMCL	1	0.900	-	-		OOG6_102427
Panther	1	1.100	-	-	LDO	PTHR23119
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5064
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.880