DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SCRIB and Lap1

DIOPT Version :10

Sequence 1:NP_874365.3 Gene:SCRIB / 23513 HGNCID:30377 Length:1655 Species:Homo sapiens
Sequence 2:NP_611007.1 Gene:Lap1 / 36670 FlyBaseID:FBgn0033984 Length:849 Species:Drosophila melanogaster


Alignment Length:911 Identity:260/911 - (28%)
Similarity:408/911 - (44%) Gaps:166/911 - (18%)


- Green bases have known domain annotations that are detailed below.


Human     3 KCIPLWRCNRH--VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLG 65
            ||.|.::..|.  ::.:|..:..|...| |::::.|:||||.|...:|:.||...|....||.|.
  Fly     6 KCFPCFKFKREEVIDKLDYSNTPLTDFP-EVWQHERTLEELYLSTTRLQALPPQLFYCQGLRVLH 69

Human    66 LSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSL 130
            ::.|.::.:|..:.:..||..||::||.|..:||.||.||.|...|.|.|.|.||||..|.|.||
  Fly    70 VNSNNLESIPQAIGSLRQLQHLDLNRNLIVNVPEEIKSCKHLTHLDLSCNSLQRLPDAITSLISL 134

Human   131 AHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGA 195
            ..|.||:..|:.||.:.|.|.||..||||.|.|.:||.|:..|:.|::||:|||:...||:.:|.
  Fly   135 QELLLNETYLEFLPANFGRLVNLRILELRLNNLMTLPKSMVRLINLQRLDIGGNEFTELPEVVGE 199

Human   196 LPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPD 260
            |.:|||||:|.||:..:...:|.||.|...:.:.|.|:.||:||.....:..|.:..|.|...|.
  Fly   200 LKSLRELWIDFNQIRRVSANIGKLRDLQHFEANGNLLDTLPSELSNWRNVEVLSICSNSLEAFPF 264

Human   261 GIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLE 325
            .:|.||.|...|.:.|.|.|:.::|...|.|.||:|:.|.|:.||.::|.|..|..|..|.|.|.
  Fly   265 SVGMLKSLVTFKCESNGLTELPDSISYLEQLEELVLSHNKLIRLPSTIGMLRSLRFLFADDNQLR 329

Human   326 ALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWLAE 389
            .||.|:..|..|||||:.:|:|:.||..:.:.:::.||:|..|.:.:||.::.:| ||.::||::
  Fly   330 QLPDELCSCQQLSVLSVANNQLSALPQNIGNLSKMKVLNVVNNYINALPVSMLNLVNLTSMWLSD 394

Human   390 NQAQPMLRFQTEDDARTGEKVLTCYLLP--------------------------QQPPPS----L 424
            ||:||::..|..|.:...:  |||::||                          |||..|    :
  Fly   395 NQSQPLVPLQYLDASTKTQ--LTCFMLPQVTFKMNSIQAQQQAQEQYEFVYANQQQPHASPSRRI 457

Human   425 EDAGQQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSELKVMKRSIE 489
            ..|.:...||...:...|:..|.:.....|..|:.|....     |.|..||:|.||:.|.:.: 
  Fly   458 CFAEEATILSNAKAQPAPNYPSFVAAPPTPTPDQMAGSVR-----LMRSPTPYPKELRQMSKYV- 516

Human   490 GRRSEACPCQPDSGSPLPAEEEKRLSAESGLSEDS---------RPSASTVSEAEPEGPSAEAQG 545
             |:::|.    .|.:......|.|:.....:..||         :.:.|.:....||  :....|
  Fly   517 -RQAQAA----TSSANASEVREARVVTNGQIHCDSNNANQDVVDQATTSAIYGIAPE--TTHIYG 574

Human   546 ---GSQQEATTAGGEE-------DAEEDYQE---------PTVHFAEDALLPGD-DREIE--EGQ 588
               ..||.|.....:|       :.|..||:         ||.|      |.|| |.|::  :.|
  Fly   575 VYQQPQQMAHPVPTQEYYGLPLVNYEAHYQQLYVEANTPLPTTH------LNGDQDYELQPLQQQ 633

Human   589 PEAPWTLPGGRQRLIRKDTPHYKKHFKISKLPQPEAVVALLQGMQPDGEGPVAPGGWHNGPHAPW 653
            |.....||..|    .:..|::.......|.|:.   :.|.:.|                     
  Fly   634 PMQQQALPTPR----LEPPPYHIARVYTKKTPED---LNLYESM--------------------- 670

Human   654 APRAQKEEEEEEEGSPQEEEEEEEEENR-----AEEEEASTEEEDKEGAVVSAPSVKGVSFDQAN 713
              |.:|::::.:|.:..::........:     |::.|.|.::.|.:..:             :|
  Fly   671 --RQRKQQQQLQEQTIYQDALNSNSNFKTTAIGAQDVEESVDQLDYQNNI-------------SN 720

Human   714 NLLIEPARIEEEELTLTI----LRQTGGLGISIAGGKGSTPYKG--------------------- 753
            ||...|.. |::||..|:    |..|.....|.|..|.||...|                     
  Fly   721 NLEPNPEE-EDQELDDTMSQHSLNSTATNNTSKASHKKSTWIFGVHKNPTVKQVTLKWENSIGFD 784

Human   754 -----DDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWR 813
                 :..|||:|.::....|||. :.:.|||||::|..|..|...:|...|...||.:.:.:.|
  Fly   785 IAELLNQVGIFVSSITPNTNAARL-LNLNDKLLEIDGYDLTNANLSDAKRVLLNCGTVMNIMLSR 848

Human   814 E 814
            :
  Fly   849 K 849

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SCRIBNP_874365.3 Sufficient for targeting to adherens junction and to inhibit cell proliferation 1..818 260/911 (29%)
leucine-rich repeat 14..37 CDD:275380 4/22 (18%)
LRR_8 36..94 CDD:404697 21/57 (37%)
leucine-rich repeat 38..60 CDD:275380 9/21 (43%)
leucine-rich repeat 61..83 CDD:275380 5/21 (24%)
leucine-rich repeat 84..106 CDD:275380 11/21 (52%)
LRR 87..>396 CDD:443914 129/309 (42%)
leucine-rich repeat 107..129 CDD:275380 11/21 (52%)
leucine-rich repeat 130..152 CDD:275380 9/21 (43%)
leucine-rich repeat 153..175 CDD:275380 11/21 (52%)
leucine-rich repeat 176..198 CDD:275380 10/21 (48%)
leucine-rich repeat 199..221 CDD:275380 10/21 (48%)
leucine-rich repeat 268..290 CDD:275380 6/21 (29%)
leucine-rich repeat 291..313 CDD:275380 10/21 (48%)
leucine-rich repeat 314..336 CDD:275380 9/21 (43%)
leucine-rich repeat 360..381 CDD:275380 7/21 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 417..440 8/52 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 459..606 40/177 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 628..702 9/78 (12%)
Interaction with ARHGEF7. /evidence=ECO:0000269|PubMed:15182672 717..1229 33/128 (26%)
PDZ1_Scribble-like 727..813 CDD:467188 29/115 (25%)
Required for interaction with VIM. /evidence=ECO:0000269|PubMed:19386766 728..1194 29/117 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 827..853
PDZ2_Scribble-like 859..950 CDD:467187
PDZ3_Scribble-like 1003..1091 CDD:467186
PDZ4_Scribble-like 1095..1192 CDD:467185
Interaction with tick-borne encephalitis virus RNA-directed RNA polymerase NS5. /evidence=ECO:0000269|PubMed:18042258 1105..1117
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1227..1246
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1277..1489
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1520..1568
AbLIM_anchor 1555..>1630 CDD:465046
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1622..1655
Lap1NP_611007.1 LRR 12..407 CDD:443914 152/395 (38%)
leucine-rich repeat 21..41 CDD:275380 4/20 (20%)
leucine-rich repeat 42..64 CDD:275380 9/21 (43%)
leucine-rich repeat 65..87 CDD:275380 5/21 (24%)
leucine-rich repeat 88..110 CDD:275380 11/21 (52%)
leucine-rich repeat 111..133 CDD:275380 11/21 (52%)
leucine-rich repeat 134..156 CDD:275380 9/21 (43%)
leucine-rich repeat 157..179 CDD:275380 11/21 (52%)
leucine-rich repeat 180..202 CDD:275380 10/21 (48%)
leucine-rich repeat 203..225 CDD:275380 10/21 (48%)
leucine-rich repeat 226..248 CDD:275380 7/21 (33%)
leucine-rich repeat 272..294 CDD:275380 6/21 (29%)
leucine-rich repeat 295..317 CDD:275380 10/21 (48%)
leucine-rich repeat 318..340 CDD:275380 9/21 (43%)
leucine-rich repeat 364..386 CDD:275380 7/21 (33%)
PDZ_canonical 778..846 CDD:467153 19/68 (28%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.