Protein Alignment NUP188 and NUP188

DIOPT Version :10

• Sequence 1: NP_056169.1
• Gene: NUP188 / 23511
• HGNCID: 17859
• Length: 1749
• Species: Homo sapiens
• Sequence 2: NP_013604.1
• Gene: NUP188 / 854868
• SGDID: S000004571
• Length: 1655
• Species: Saccharomyces cerevisiae
• Alignment Length: 1960
• Identity: 358/1960 - (18%)
• Similarity: 651/1960 - (33%)
• Gaps: 638/1960 - (32%)

Human    27 RELSQIEAELNKHWRRLLEGLSYYKPPSPSSAEKVKANKDVASPLK------------------- 72
            ::|:||...|..:...|:|.|:..:....||.:..|....:|:.|:
Yeast    35 KQLAQIRQFLKANKTNLIESLNTIRQNVTSSGDHNKLRSTIANLLQINVDNDPFFAQSEDLSHAV 99

Human    73 ---------------------ELGLRISKFLGLDEEQSV--------QLLQCY-------LQEDY 101
                                 ::.|....|:..|....|        .::|.|       |..||
Yeast   100 EFFMSERSSRLHIVYSLLVNPDIDLETYSFIDNDRFNVVGKLISIISSVIQNYDIITASSLAHDY 164

Human   102 RGTRDSVKTVLQDERQSQALILKIADYYYEERTCILRCVLHLL------------------TYFQ 148
            ...:|....|      |...:.|.:|         |:.:|.:|                  .:|.
Yeast   165 NNDQDMFTIV------SLVQLKKFSD---------LKFILQILQILNLMILNTKVPVDIVNQWFL 214

Human   149 DERHPYRVEYADCVDKLEKEL----VSKYR-QQFEELYKTEAPTWETHGNLMTERQVSRWFVQCL 208
            ..::.: ||:...::..:|.:    :..|: |.|::|            :.::|..:||     :
Yeast   215 QYQNQF-VEFCRNINSTDKSIDTSSLQLYKFQNFQDL------------SYLSETLISR-----I 261

Human   209 REQSMLLEIIFL----YYAYFEMAPSDLLVLTKMFKEQGFG-SRQTNRHLVDETMDP-FVDRIGY 267
            .....:..|:.|    ..|.|:: .|.|.:.|:.|...... ......::|:|  || |...|.|
Yeast   262 SSLFTITTILILGLNTSIAQFDI-QSPLYMDTETFDTVNSALENDVATNIVNE--DPIFHPMIHY 323

Human   268 FSALILV--------EGMDIESLHKCALDDRRELHQFAQDGLICQDMDCL--MLTFGDIPHHAPV 322
            ..:.||.        |..|...:.|.||        ||:...:.|.::.|  :|:|.  |.:..|
Yeast   324 SWSFILYYRRALQSSESFDDSDITKFAL--------FAESHDVLQKLNTLSEILSFD--PVYTTV 378

Human   323 LLAWALLRHTLN----PEETSSVVRKIGGTAIQLNVFQYLTRLLQSLASGGNDCTTSTACMCVYG 383
            :..:  |..:||    ...||.|..||...|.:..:..:||          ||
Yeast   379 ITVF--LEFSLNFIPITASTSRVFAKIISKAPEQFIENFLT----------ND------------ 419

Human   384 LLSFVLTSLELHTLGNQQDIIDTACEVLADPSLPELFWGTEPTSGLGIILDSVCGMFPHLLSPLL 448
                        |...:..||.....:|.:..:|.:......|......|..:|. |....|.|.
Yeast   420 ------------TFEKKLSIIKAKLPLLNESLIPLINLALIDTEFANFELKDICS-FAVTKSSLN 471

Human   449 QLLRALVSGKSTAKKVYSFLDKMSFYNELYKHKPHDVISHEDGTLWRRQTPKLLY---------P 504
            .|...|::...|.....|                 |:|           .|.|:.         |
Yeast   472 DLDYDLIADTITNSSSSS-----------------DII-----------VPDLIELKSDLLVAPP 508

Human   505 LGGQTN---LRIPQGTVGQVML----------------DDRAYLVRWEYSYSSWTLFTCEIEMLL 550
            |..:.:   |.||:.|.|:::.                ...:.|:.:.|.::.|:|....::.||
Yeast   509 LENENSNCLLSIPKSTKGKILTIKQQQQQQQQQNGQQPPTTSNLIIFLYKFNGWSLVGRILQNLL 573

Human   551 HVV----STADVIQHCQRVKPIIDLVHKVISTDLSIADCLLPITSRIYMLLQRLTTVISPPVDVI 611
            |..    :..|.:|| :.:..||.||..|:....||...            ..:.:.:|..:|..
Yeast   574 HSYMEKGTQLDDLQH-ELMISIIKLVTNVVDPKTSIEKS------------SEILSYLSNSLDTS 625

Human   612 ASCVNCLTVLAA-------RNPAKVWTDLRH-----TGFLPFVAHPVSSL---SQMISAEGMNAG 661
            ||.:|..:::..       ....|.:|.:..     |...|...|.|||.   |.::...|..
Yeast   626 ASTINGASIIQVIFEIFEISLQRKDYTSIVQCCEFMTMLTPNYLHLVSSYLNKSDLLDKYGKT-- 688

Human   662 GYGNLLMNS-EQPQGEYGVTIAFLRLITTLVKGQLG------STQSQ-GLVPCVMFVLKEMLPSY 718
            |..|:::.| |...|:|..||..|:|....::..|.      |.:|: .::..::.....:..||
Yeast   689 GLSNMILGSVELSTGDYTFTIQLLKLTKVFIRESLSLKNIHISKRSKIDIINKLILHAIHIFESY 753

Human   719 HKWRYNSHGVREQIG----CLILELIHAILNL-CHETD---LHSSHTPSLQFLCICSLAYTEAGQ 775
            :.|:||:...:.:|.    .:..:::|.:..: .|:.|   :.||....||.......:...|..
Yeast   754 YNWKYNNFLQKFEIAFHLTLIFYDVLHDVFTINPHQKDQLIISSSANKLLQLFLTPMDSIDLAPN 818

Human   776 TVINIMGIGVDTIDMVMAAQPRSDGAEGQGQGQLLIKTVKLAFSVTNNVIRLKPPSNVVSP--LE 838
            |:.||:...::|...::.         .:..|.|..|.:..:|.:...:|.::..:..:.|  ||
Yeast   819 TLTNILISPLNTTTKILG---------DKILGNLYSKVMNNSFKLCTLLIAIRGSNRDLKPSNLE 874

Human   839 QALSQHGAHGNNLIAV--LAKYIYHKHDPALPRLAIQLLKRLATV--APMS-----VYACLGN-D 893
            :.|.   .:.:.|:.|  |..|::.|         :|:::.|:.:  ||.:     :.:.||. .
Yeast   875 KLLF---INSSKLVDVYTLPSYVHFK---------VQIIELLSYLVEAPWNDDYPFLLSFLGEAK 927

Human   894 AAAIRDAFLTRLQSKIEDMRIKVMILEFLTVAVET-QPGLIELFLNLEVKDGSDGSKEFSLGMWS 957
            :.|.....|:.|.|.::|..:...:..|.|..:|: |.||..|||..:.......:.|.|:
Yeast   928 SMAFLKEVLSDLSSPVQDWNLLRSLYIFFTTLLESKQDGLSILFLTGQFASNKKINDESSI---- 988

Human   958 CLHAVLELIDSQQQDRYWCPPLLHRAAIAFLHALWQDRRDSAMLVLRTKPKFWENLTSPLFGTLS 1022
                                                |::.|.:.||:......:          |
Yeast   989 ------------------------------------DKKSSILTVLQKNSLLLD----------S 1007

Human  1023 PPSETSEPSILETCALIM------KIICLEIYYVVKGSLDQSLKDTLKKFSIEKRFAYWSGYVKS 1081
            .|.|.| ..:|||...::      ||...:..:|  .||...|||:.|.|..::...
Yeast  1008 TPEEVS-CKLLETITYVLNTWTNSKIFIKDPKFV--NSLLAKLKDSKKLFQKKENLT-------- 1061

Human  1082 LAVHVAETEGSSCTSLLEYQMLVSAWRMLLIIATTHADIMHLTDSVVRRQLFLDVLDGTKALLLV 1146
                     .....||::...|:|  |::.|.|..   |.:.|||......||:..|      |.
Yeast  1062 ---------RDETVSLIKKYKLIS--RIVEIFALC---IYNSTDSNSEILNFLNQED------LF 1106

Human  1147 PASVNCLRLGSMKCT----LLLILLRQW-KRELGSVDEILGPLTEI------------LEGVLQA 1194
            ....:..::.....|    |.|....:| ..||.|..:|  ||:.|            |:.||:|
Yeast  1107 ELVHHFFQIDGFNKTFHDELNLKFKEKWPSLELQSFQKI--PLSRINENENFGYDIPLLDIVLKA 1169

Human  1195 DQQLMEKTKAKV-FSAFIT----VLQMKEMKVSDIPQYSQLVLNVCETLQEEVIALFDQTRHSLA 1254
            |:...|.:|::. |...||    .||....::|....:..|:....:             |.::.
Yeast  1170 DRSWNEPSKSQTNFKEEITDASLNLQYVNYEISTAKAWGALITTFVK-------------RSTVP 1221

Human  1255 LGSATEDKDSMETDDCSRSRHRDQRDGVCVLGLHLAKELCEVDEDGDSWLQV-TRRLPILPTLLT 1318
            |                       .||...|..|..|...:...|...:.|: ..|:.:...:|.
Yeast  1222 L-----------------------NDGFVDLVEHFLKLNIDFGSDKQMFTQIYLERIELSFYILY 1263

Human  1319 TLEVSLRMKQNLHFTEATLHLLLTLARTQQ-GATAVAGAGITQSICLPLLS----VYQLSTNGTA 1378
            :.::|.::.:.....| .::.:.|:.::.: ......|..:..:...|||.    :.:|.::|.
Yeast  1264 SFKLSGKLLKEEKIIE-LMNKIFTIFKSGEIDFIKNIGKSLKNNFYRPLLRSVLVLLELVSSGD- 1326

Human  1379 QTPSASRKSLDAPSWPGVYRLSMSLMEQLLKTLR-------YNFLPEALDFV------GVHQERT 1430
                               |....:.:|||:...       |..|.|.|..:      |:..:.|
Yeast  1327 -------------------RFIELISDQLLEFFELVFSKGVYLILSEILCQINKCSTRGLSTDHT 1372

Human  1431 LQCLNAVRTVQSLACLEEADHTVGFILQLSNF--------MKEWHFHLPQLMRDI---------- 1477
            .|.:|          ||  |:|...:|.||.|        .|.::..|...:.::
Yeast  1373 TQIVN----------LE--DNTQDLLLLLSLFKKITNVNPSKNFNVILASSLNEVGTLKVILNLY 1425

Human  1478 ---------------QVNLGYLCQACTSLLHSRKMLQHYLQNKNGDGLPSAVAQRVQRPPSAASA 1527
                           |:.|.::.:.|:....:.|::        ..||.|.:.:
Yeast  1426 SSAHLIRINDEPILGQITLTFISELCSIEPIAAKLI--------NSGLYSVLLE----------- 1471

Human  1528 APSSSKQPAADTEASEQQALHTV-QYGLLKILSKTLAALRHF----TPDVCQIL--LDQSLDLAE 1585
            :|.|......|.:......||.: ..|||.|:   |..|..|    .|:.|..:  ..:.:....
Yeast  1472 SPLSVAIQQGDIKPEFSPRLHNIWSNGLLSIV---LLLLSQFGIKVLPETCLFVSYFGKQIKSTI 1533

Human  1586 YNFLFALSFTTPTFDSEVAPSFGTL-----LATVNVALNMLG--EL-------DKKKEPLTQAVG 1636
            ||:          .|:::|.|...:     |..:...||:|.  ||       |.::|.:...:|
Yeast  1534 YNW----------GDNKLAVSSSLIKETNQLVLLQKMLNLLNYQELFIQPKNSDDQQEAVELVIG 1588

Human  1637 LSTQAEGTRTLKSLLMFTMENCFYLLISQAMRYLRDPAVHPR-----------DKQRMKQELSSE 1690
            |.::.:..|...:|..|                    ..||:           ::|:..::.||.
Yeast  1589 LDSEHDKKRLSAALSKF--------------------LTHPKYLNSRIIPTTLEEQQQLEDESSR 1633

Human  1691 LSTLLSSLSR 1700
            |. .:..:||
Yeast  1634 LE-FVKGISR 1642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NUP188	NP_056169.1	Nup188	31..941	CDD:463110	205/1083 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1514..1542		3/27 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1707..1733
NUP188	NP_013604.1	Nup188	39..976	CDD:463110	207/1110 (19%)
		Nup188_C	<1407..>1498	CDD:436451	24/136 (18%)