Protein Alignment NUP188 and Nup188

DIOPT Version :10

• Sequence 1: NP_056169.1
• Gene: NUP188 / 23511
• HGNCID: 17859
• Length: 1749
• Species: Homo sapiens
• Sequence 2: NP_001246283.1
• Gene: Nup188 / 36397
• FlyBaseID: FBgn0033766
• Length: 1866
• Species: Drosophila melanogaster
• Alignment Length: 333
• Identity: 70/333 - (21%)
• Similarity: 117/333 - (35%)
• Gaps: 98/333 - (29%)

Human   443 GAISTPVKHVDDHPPKAVEEVTVEKNEKQTPTLPEPKPVYAQVGQPDVDLPVSPSDGAL--PNSA 505
            ||.:....|:.|:|     .||:|.|              |.....:||..:.||...:  |::.
  Fly   111 GAANIRQIHLADNP-----TVTIETN--------------AFSSLSNVDRLILPSGIRVIEPDAF 156

Human   506 H---EDGILR------PSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQIL 561
            :   ..|.|:      .|::...||....:.|.....:|:||..||       |.|||.:.:.:.
  Fly   157 YGLETVGYLKLSFMDLTSLEPYTFRGLTHIKLLSLQESDLGIIRAG-------AFEGLVQVELLN 214

Human   562 RVN---------NVDFTNIIREEAVL-----FLLDLPKGEEVTILAQKKKDV----------YRR 602
            .:|         |:...|.||   ||     .||:.|:...:.:.......|          ...
  Fly   215 ILNNKIDAIQELNITAANRIR---VLRIQGNHLLETPESGSIVLEGIDTLHVNSNYFPCGCHIHT 276

Human   603 IVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAI-RIGKNHKEVERGI 666
            :::|.:.:..|: :|    ..:|.|...:|......::.  ||...|.:.| .||:..::|.|
  Fly   277 LLDSPLSNGTYV-SH----SGAPAGDFLSKNYCISPLEV--NGMPMSSIDIYSIGRCLEQVTR-- 332

Human   667 IPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSRED------------LSAQP- 718
             .|...|..:.|...         |...|. |.|:....:.::|.|.            |:|.|
  Fly   333 -ENLEAANSVISTML---------RGQSWN-RWLQWRSEHSKRSHETTLISTVSSAVRFLAASPI 386

Human   719 VQTKFPAY 726
            :..||..|
  Fly   387 IAIKFVVY 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NUP188	NP_056169.1	Nup188	31..941	CDD:463110	70/333 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1514..1542
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1707..1733
Nup188	NP_001246283.1	Nup192	31..943	CDD:475157	70/333 (21%)