Protein Alignment NUP188 and nup184

DIOPT Version :10

• Sequence 1: NP_056169.1
• Gene: NUP188 / 23511
• HGNCID: 17859
• Length: 1749
• Species: Homo sapiens
• Sequence 2: NP_593414.2
• Gene: nup184 / 2541770
• PomBaseID: SPAP27G11.10C
• Length: 1628
• Species: Schizosaccharomyces pombe
• Alignment Length: 1807
• Identity: 355/1807 - (19%)
• Similarity: 617/1807 - (34%)
• Gaps: 490/1807 - (27%)

Human    30 SQIEAELNKHWRRLLEG----LSYYKPP---SPSSAEKVKANKDVASPLKELGLRISKFLGLDEE 87
            |.:...||.:  :..||    ||.|...   |.|..|.||              :||...|.:|.
pombe    43 SPVTGTLNSN--KTTEGEEAKLSIYDSSHSISKSQLESVK--------------KISDITGYNEA 91

Human    88 QSVQLL---QCYLQEDYRGTRDSVKTVLQDERQSQALILKIADYYYEERTC--ILRCVLHLLTYF 147
            |...:|   |..|...|....|: .:||..|.|.:        ||.|..:|  :|..:|...|..
pombe    92 QVAYVLLVHQYELNTQYFSQLDN-DSVLAQEFQRR--------YYAEIISCWKVLAFLLQACTDA 147

Human   148 QDERHPYRV--------------EYAD-------CVDKLEKELVSKYRQQFEELYKTEAPTWETH 191
            ..:.|....              |.|.       ||..:  :.:||...|       .||...|.
pombe   148 DSKWHKMATRLIVSIFQTAQRSGENAQSTTPSIFCVRII--DYLSKMTSQ-------AAPASLTF 203

Human   192 GNLMTERQVSRWFVQCLREQSMLLEIIFLYYAYFEMAPSDLLVLTKMFKEQGFGSRQTNRHLVD- 255
            ..   |..:|:|:......|..||.:|||       :...|:|.........|...:..|:|.|
pombe   204 NG---EEAISQWYFFHFNLQLQLLRVIFL-------STYSLVVCNSEMAISWFNCMKKTRYLHDQ 258

Human   256 ETMDPFVDRIGY-----FSALILVEGMDIESLHKCALDDRRELHQFAQDGLICQDMDCLMLTFGD 315
            |.|...:| .|:     .:.:.::..::..||.|..|..:.....|...|.....:..::....:
pombe   259 EFMHLDID-TGFSMCKEITNVAIIISINFISLEKQVLSFKDNPSFFMLSGNTIISLHDMITQLSN 322

Human   316 IPHHAPVLLAWALLRHTL--NPE-----ETSSVV------------RKIGGTAIQLNVFQYLTRL 361
            ....|.|.|.|.:..|.|  :|:     :.||||            :.:...|::.:.|..:.|:
pombe   323 DSIGAAVSLTWGIALHLLSNSPDNIPLIQNSSVVSSKILQNPQNSFQALIIAALKYDPFTLIHRI 387

Human   362 LQSLAS----GGNDCTTSTACMCVYGLLSFVLTSLELHTLGNQQDIIDTACEVLADPSLPELFWG 422
            :.||..    .|            |..:...|.|..:..:......:..|..:...|.:.:||
pombe   388 ISSLEDDPYIDG------------YSKIMATLFSSAVSYVKFSDSTMLCATTLFKTPQVYQLF-- 438

Human   423 TEPTSGLGIILDSVCGMFPHLLSPLLQLLRALVSGKSTAKKVYSFLDKMSFYNELYK--HKPHDV 485
             |....:..:|:.....||...|..:.||....:..::.:.|.|.|..|:.:.:...  .|.:::
pombe   439 -ENNDSVTRLLNFARARFPFEYSQFVLLLIPTFACLTSKQLVSSELLHMTTFTQSLPSGFKAYEI 502

Human   486 ISHEDGT---LWRRQTPKLLYPLG---GQTNLRIPQGTVGQVM-LDDRAYLVRWEYSYSSWTLFT 543
            |...:.|   |...|....|...|   ......:|:||.|::: :|....:|.|:.:||.|....
pombe   503 IPEPNVTGNALIELQESLHLDSYGFFFPNAERSLPKGTRGRIVSVDTYPPVVMWDLNYSLWEAVG 567

Human   544 CEIEMLLHVVSTADVIQHCQRVKPIIDLVHKVISTDLSIADCLLPITSR--------IYMLLQRL 600
            ..:.   ::|....:..|...|..::.....:..||:|.|..|:.:.|.        |.::...|
pombe   568 ISLN---YIVRNGLINSHKSFVLTVLSSSVPLFQTDVSGACELVHLASEGLDGELDFINVICDLL 629

Human   601 TTVISPPVDVIAS-----CVNCLTVL------AARNPAKVWTDLRHTGFLPFVAHPVSSLSQMIS 654
            ...:|  :.||..     ||:.|.:|      ||.:   ||            |:...||..:.|
pombe   630 DYFLS--LSVIEDADYQICVSSLRLLREFTRFAATD---VW------------AYVTRSLVCVGS 677

Human   655 AEGMNAGGYGNLLMNSEQPQGEYGVTIAFLRLI---------TTLVKGQLGSTQSQGLVPCVMFV 710
            .:|::   ..:::.:.|...|.|..|:||..|.         |::|............|...|..
pombe   678 EKGIS---LEDVIFDYESINGVYDFTLAFFDLYEILLDNCISTSVVPDDFSIRLKTDFVKRAMRF 739

Human   711 LKEMLPSYHKWRYNSHGVREQIGCLILELIHAILNLCHETDLHSSHT------------------ 757
            |.|:..:|..|:|.....:.|||.....||..:||:....:..:..|
pombe   740 LCEVFANYLDWKYARIIQQYQIGHRFASLITKLLNVTFGIEYFNPKTTVNKKTLPLRELSHYIVQ 804

Human   758 -------------PSLQFLCICSLAYTEAGQTVINIMGIGVDTIDMVMAAQPRSDGAEGQGQGQL 809
                         |.|..:.:.:|.||:...|:                :.||:..|:     ..
pombe   805 RFLVQQDSNRYLHPLLSVMDLINLLYTDIFSTI----------------SSPRAKAAK-----MW 848

Human   810 LIKTVKLAFSVTNNVI------RLKPPSNVVSPLEQALSQHGAHGNNLIAVLAKYIYHKHDPALP 868
            ||.    :|.....:|      .|||     |.||:.|........|               .||
pombe   849 LIS----SFCAMKTLICLRGFLNLKP-----SELERELFSRSPDLFN---------------CLP 889

Human   869 RL------AIQLLKRLATVAPM-----SVYACLGNDAAAIRDAFLTRLQSKIEDMRIKVMILEFL 922
            ||      .:|||..| .:||.     |:.|.:.|....:....:..|.:.|:...|:..:.:||
pombe   890 RLLCCIAPILQLLSAL-ILAPWPSETPSLLAYMINSTDIVGRVCIQILTNPIQSTNIEGSVWKFL 953

Human   923 TVAVE-TQPGLIELFLNLEVKDGSDGSKEFSLG-MWSCLHAV--------LELIDSQQQDRYWCP 977
            :..:: .|.||..|..:         .|:|.|. |.|..|.|        |..:..::.|.:...
pombe   954 SSIMKGQQQGLAVLLFS---------GKKFPLDRMKSLNHNVDVQLTSKSLISLAEKRLDSFSIN 1009

Human   978 PLLHRAAIAFLHALWQDRRDSAMLVLRTKPKFWENLTS----PLFGTLSPPSETSEPSILETCAL 1038
            .:|.:..:.....|.::...:::..|:.:..||..:..    ||...|...|..::..:....|.
pombe  1010 DILSQVPVFEFIFLSRNFWTASLGNLQQEANFWNRIVDAIKLPLTVKLDGLSSVAQADLYILAAH 1074

Human  1039 IMKIICLEIYY-----------VVKGSLDQSLKDTLK-KFSIEKRFAYWSGYVKSLA-------- 1083
            ..:|..::::.           ::...|..|:||.:: .|:|.   ||.|....:|.
pombe  1075 ATRITAIQLHMSKLNKSNSSKKIIIDPLKDSMKDLVQHAFTIT---AYDSNIHNALTRAFKHENG 1136

Human  1084 -VHVAE----------------------------TEGSSC-----------TSLLEYQ-MLVSAW 1107
             :|:::                            ||.:|.           .|||:.| .|:.:|
pombe  1137 DLHISDLRNTGLFPLRYGDNYFYNIKLAKNMLLNTEDTSFKISMMMSANENLSLLDAQAALLRSW 1201

Human  1108 RMLLIIATTHADIMHLTDSVVRRQLF-----------LDV-----LDGTKALLLVPASVNCLRL- 1155
             .:.|.|.........|.|::..::.           :||     |...:|.|:...|...|.:
pombe  1202 -SIFICAFVEFVKEDATLSILELKIMKWVLKSLAEDTIDVNVVQELSAERAALVFRISQQTLAIP 1265

Human  1156 --GSMKCTLLLILLRQWK----RELGSVDEILG------PLTEILEGVLQADQQLM--EKTKAKV 1206
              ..:|..|..|||..||    .:....::..|      ||..:|...|   .:|:  ||....:
pombe  1266 ISNEVKEHLQSILLLTWKAITTTKFSIYEDSNGEMAYYRPLLHVLYNTL---NRLLSEEKENLSL 1327

Human  1207 FSAFIT-VLQMKEMKVSDIPQYSQLVLNVCETLQEEVIALFDQTRHSLALGSATEDKDSMETDDC 1270
            ...|:: :||:...|:|.:  :.:.|:|....:..:::.|
pombe  1328 SVGFVSGLLQLCHRKLSQL--FEKAVINPTIEVYGDIVLL------------------------- 1365

Human  1271 SRSRHRDQRDGVCVLGLHLAKEL--CEVDEDGDSWLQVTRRLPILPTLLTTLEVSLRMKQNLHFT 1333
             .|.|:      |::..||.:.|  ..:....||: .|...|     .|.:...||.:....:|.
pombe  1366 -NSLHK------CIVNSHLIRGLQSLYISYINDSF-SVDNCL-----RLFSWSHSLLVDGQPYFA 1417

Human  1334 EATLHLLLTLARTQQGATAVAGAGITQSICLPLLSVYQLSTNGTAQTPSASRKSLDAPSWPGVYR 1398
            :|.|..||..:.:..||..:...|...||....||. .|||.|.....|    |:....|   .|
pombe  1418 DAALSFLLICSSSPAGAEQIVMNGFFYSIMESPLST-ALSTGGLGLDGS----SIQYKIW---IR 1474

Human  1399 LSMSLMEQLLKTLRYNFLPEALDFVGVHQERTLQCLNAVRTVQ-------------SLACLEEAD 1450
            ..:.|:..::|.|....:.:..:||          |.|...:|             |||.::|:
pombe  1475 GILPLLFNIVKFLGNRIMNDMREFV----------LLAFPQIQYALLNWCQPPSSISLASIDES- 1528

Human  1451 HTVGFILQLSNFMKEWHFHLPQLMRDIQVNLGYLCQACTSLLHSRKMLQHYLQNKNGDGLPSAVA 1515
               ..|:.|.:.:::::   |.|:::|:     |.:....:|.....|..:....:...:|:::.
pombe  1529 ---FMIVLLFDLLQQFN---PALLQEIR-----LAELKIEMLEGIDYLISHPNFLSSLAIPASLY 1582

Human  1516 QRVQRPPSAASAAPSSSKQPAADTEASEQQALHTVQYGLLKILSKTLAALRH 1567
            ::..............|.|...:|:.|:...|..:|      |.|..|.|.|
pombe  1583 EQEYAIDVIGIPKELESDQLTKETKTSQFAKLIRIQ------LDKLRALLEH 1628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NUP188	NP_056169.1	Nup188	31..941	CDD:463110	215/1057 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1514..1542		3/27 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1707..1733
nup184	NP_593414.2	Nup192	19..972	CDD:475157	216/1066 (20%)
		Nup188_C	1277..>1488	CDD:436451	56/261 (21%)