Protein Alignment KCTD2 and twz

DIOPT Version :10

• Sequence 1: NP_056168.1
• Gene: KCTD2 / 23510
• HGNCID: 21294
• Length: 263
• Species: Homo sapiens
• Sequence 2: NP_001246449.1
• Gene: twz / 37456
• FlyBaseID: FBgn0034636
• Length: 367
• Species: Drosophila melanogaster
• Alignment Length: 313
• Identity: 77/313 - (24%)
• Similarity: 123/313 - (39%)
• Gaps: 99/313 - (31%)

Human    19 SGVGDGGGPVRGPPSPRPAGPTPRGHGRPAAAVAQPLE-PGPGPPERAGGGG------------- 69
            |.:.....|...|.....:.|||.   .||::...||. ||......|..||
  Fly    56 SDIKISSSPTVSPTISNSSSPTPT---PPASSSVTPLGLPGAVAAAAAAVGGASSAGASSYLHGN 117

Human    70 ------------AARW---VRLNVGGTYFVTTRQTLGREPKSFLCRLCCQEDP-ELDSDKDETGA 118
                        |:|:   |.::||||.:.::.:||.:.|:|.|.:|...:.| .|||.|..
  Fly   118 HKPITGIPCVAAASRYTAPVHIDVGGTIYTSSLETLTKYPESKLAKLFNGQIPIVLDSLKQH--- 179

Human   119 YLIDRDPTYFGPILNYLRHGKLIITKELAE-EGVLEEAEFYNIASLVR----LVKERIRDNEN-- 176
            |.||||...|..|||::|:.:|:|.::..: |.:||||.:|.:..:::    :.|:|:| |.|
  Fly   180 YFIDRDGGMFRHILNFMRNSRLLIAEDFPDLELLLEEARYYEVEPMIKQLESMRKDRVR-NGNYL 243

Human   177 ---------------RTSQGPVKHVYRVLQCQEE--------ELTQMVSTMSDGWKFEQLI---- 214
                           |||..|        :|..|        :|.:.:...::....::|.
  Fly   244 VAPPTPPARHIKTSPRTSASP--------ECNYEVVALHISPDLGERIMLSAERALLDELFPEAS 300

Human   215 ------SIGSSYNYGNEDQ-----------AEFLCVVSRELNNSTNGIVIEPS 250
                  ..|.|:|.|:..|           ...:.|::|.||   .|..||.|
  Fly   301 QATQSSRSGVSWNQGDWGQIIRFPLNGYCKLNSVQVLTRLLN---AGFTIEAS 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCTD2	NP_056168.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..69		13/50 (26%)
		BTB_POZ_KCTD2	72..177	CDD:349697	40/130 (31%)
twz	NP_001246449.1	BTB_POZ_KCTD1-like	137..230	CDD:349670	34/95 (36%)