Protein Alignment BICRAL and Bicra

DIOPT Version :10

• Sequence 1: XP_047274498.1
• Gene: BICRAL / 23506
• HGNCID: 21111
• Length: 1183
• Species: Homo sapiens
• Sequence 2: NP_001263051.1
• Gene: Bicra / 43435
• FlyBaseID: FBgn0039633
• Length: 3003
• Species: Drosophila melanogaster
• Alignment Length: 1510
• Identity: 279/1510 - (18%)
• Similarity: 489/1510 - (32%)
• Gaps: 528/1510 - (34%)

Human    43 AAPRPGAGVSERESGARVAGAAR--------------PGAPALRPPAPRPPPP--------PPPP 85
            |||.....::...:|.:::...|              |.|.:.:||.|.|.|.        .||.
  Fly  1135 AAPSVAPTITSDSTGFKLSSDGRQMQLVAIPQATPPSPAASSAQPPVPTPTPALTAGGATILPPQ 1199

Human    86 LLRWRRN----------------------------PVDKALLFHDVVMDDDDDSCLL-------- 114
            |.....|                            ..::.:|.||.....|..|.|:
  Fly  1200 LTGMPANVSVSVGSPASAAALVPQLTGSLTLTVSEQCERLILRHDPNNPQDHQSQLILQALLKGA 1264

Human   115 ----DLIGDP-------------QALNYFLHGP---------------------------SNKSS 135
                .:|.:|             |.....:..|                           :|:..
  Fly  1265 LPNVTIINEPTRVDPNKQTTPMLQPQQQVIQIPQPLTQPQQILQQQPKVSTAPKIEVKVANNRKL 1329

Human   136 NDDLTNAGYSAANSNSIFANSSNADPKSSLKGVSNQLGEGPSDGLPLSSSLQFLEDELESSPL-P 199
            :..:|:...|.....|.....|...|.::|....|::...|.  |||:|.:...:..:.|:.| |
  Fly  1330 SGQVTHPASSMLGMTSTTTTMSTMKPPANLPAKQNEVVSFPQ--LPLNSQVLIQQQPMISAQLQP 1392

Human   200 DLTEDQPFDI-LQKSLQEANITEQTLAEEAYLDASIGSSQQFAQAQLHPSSSASFTQASNVSNY- 262
            .|   ||..: :....|...|.....|.:.   |:.|..:..|...:.|::...|. .::|:|.
  Fly  1393 QL---QPVTVPVSLPTQPVPIPSPAPAPQL---ANNGQQRYIALPPIDPTTQQLFC-LNSVTNQI 1450

Human   263 ----SGQTLQPIGVTH----VPVGASFASNTVGVQHGFMQHVGIS-VPSQHLSNSSQISGSG--- 315
                :|||...||.|.    .|.|.:.......:|.|.:....:: :|:|........:.|.
  Fly  1451 TAMSAGQTAASIGPTERLLIAPAGINAQQLAQCLQLGQLHFNDVNPLPAQQQQQQVATTSSSMTL 1515

Human   316 ---------QIQLIGSFGNHP-------------------------SMMTINN--------LDGS 338
                     |.|::     ||                         |:.|:..        :|.|
  Fly  1516 SMPLRPQPPQQQIV-----HPIQPITNGLAITTTASSTLTTTTSTTSLTTVTKQVANVAPIIDQS 1575

Human   339 QIILKGSGQQAPSNVSGGLLVHRQ-------TPNGNSLFGNSSSSPVAQPVTVPFNSTNFQTSLP 396
            :..|: ..:.|.|...||.:|.::       ||...|...|..::.|.:|             :|
  Fly  1576 KAKLE-PAKAATSGAGGGAVVKKKPVRKPKATPTNASELANLKNASVVKP-------------MP 1626

Human   397 VHNIIIQRGLAPNSNKVPINIQPKPIQMGQQ-----------NTYNVNNLGIQQHHVQQGISFAS 450
            ..:.:.|:   ||:|.|.| :||. :..|:|           .|....:..||......|.....
  Fly  1627 KLDPLSQK---PNNNPVQI-VQPN-VASGKQMIVVGSSSCTTTTTTTMSASIQPFQTTSGTKLVG 1686

Human   451 ASSPQGSVVGPHMSVNIVNQQNTRKPVTSQAVSSTGGSIVIHSPMGQP----------------- 498
            .:.|. ....|..:..|:.||..::  ||.::::|  ::...:||..|
  Fly  1687 VTVPM-QQQQPTGTAAILQQQQQQR--TSFSLTAT--TVATPAPMPSPTVASGVSQLQMQQLPSQ 1746

Human   499 --------------HAPQSQFLIPTSLSVSSNSVHHVQTINGQLLQTQPSQLISGQVASEHVMLN 549
                          |||:.|...|       |:|..||||  ||  |...|.|..||..:...|.
  Fly  1747 QAQQQLQPQQQQQLHAPKQQQPQP-------NTVSRVQTI--QL--TPQMQQIFKQVQMQIQFLT 1800

Human   550 ---RNSSNML--------RTNQPYTGPMLNNQNTAVHLVSGQTFA------ASGSPVIANHASPQ 597
               :|.|..|        .|...|..||.:.:   ::|...:.||      |||..|    .:|:
  Fly  1801 IKLQNKSTFLPVSPEIDSATIAAYNKPMTDAE---INLALQRLFAEQHRILASGKEV----PTPE 1858

Human   598 LVGGQMPLQQASPTVLHLSPGQSSVSQGRPGFATMPSVTSM-----------SGPSRFPAVSSAS 651
               |.:|                 .:.|..||:.||.....           :.|.....:..|:
  Fly  1859 ---GMLP-----------------TANGTGGFSLMPQPVQQQQQQQQQQLQSTVPEPLKTIVPAN 1903

Human   652 TAHPS------LGSAVQSGSSGSNF---------------------------------------- 670
            ...|:      .|:|....::.:|.
  Fly  1904 VVQPNNHSSTPAGAATSGATTAANIQQNITQRIHIYPMQHQQQQQQQQQQQQQQPQHQQQQPQHQ 1968

Human   671 ---TGDQLTQPNRTPVP-------VSVSHRLPVSSSKSTS---TFSNTPGTGT------------ 710
               ||.:..|....|.|       :.:..:.|.:.||.||   ..:..|..||
  Fly  1969 LQQTGAKPKQAQPKPPPQQEQQSQLQIKPKEPANRSKVTSQQLQQNPQPPNGTINMLPQKVSMMP 2033

Human   711 ------QQQFFCQAQKKCLNQTSP---ISAPKTTDGLRQAQIPGLLSTTLPGQDSGSKVIS-ASL 765
                  |||.....|:..||::.|   |.|..|.      .:....|..|...:|..:|.: ..|
  Fly  2034 VVQQQQQQQPQQHQQQPMLNKSGPPPLIFASSTN------MLSNSNSNNLHNSNSAMQVNNMLPL 2092

Human   766 GTAQPQQE------------------------------KVVGSSPGHPAVQVESHSGGQKRPAAK 800
            ...||||:                              .:|.|.|..|::.:...|...:.|..|
  Fly  2093 PPLQPQQQPQPQLQQPPTPILPPVAPTMAMGVAPGPMGNLVPSLPTIPSLPLYMPSKMDEMPTQK 2157

Human   801 -QLTKGAFILQQLQRDQAHTVTPD-KSHFRSLSDAVQRLLSYHVCQGS---MPTEEDLRKVDNEF 860
             ::.:.:..::||:.||...:.|| ...||:..:||:||:.||....:   :|::|     |.||
  Fly  2158 PKIARLSLFVRQLEVDQESCLKPDYVKPFRTKDEAVKRLIRYHCMHENDVELPSDE-----DEEF 2217

Human   861 ETVATQLLKRTQAMLNKYRCLLLEDAMRINPSAEMVMIDRMFNQEERASLSR----DKRLALVDP 921
            |:.|.:...:.:.:..|::.:|::::...:.::|::.:.::...:.:..::.    :|.|
  Fly  2218 ESTALEFQDKFRQLNGKFQEILMQESTLPHRTSELLQMQQLMIDDLKGEINEIRTAEKEL----- 2277

Human   922 EGFQADFCCSFKLDKAAHETQFGRSDQHGSKASSSLQPPAKAQGRDRAKTGVTEPMNH------- 979
                              |.|. :.:|...|:::.....::|:.::..|   .||::.
  Fly  2278 ------------------EQQL-KEEQTSEKSTAESDVLSEAKVKEEIK---QEPIDKSAQPDGV 2320

Human   980 -DQFHLVPNHIVVSAEGNISKKTECLGRALKFDKVGLVQYQSTS----EEKASRREPLKASQCSP 1039
             |:|.|:.|    ||:.|.:           |.|   .|.|.|:    ||.....||  :...|.
  Fly  2321 VDKFDLLKN----SADVNKA-----------FSK---SQPQQTTTVKQEESNESGEP--SVNGSV 2365

Human  1040 GPEGHRKTSSR------SDHGTESKLSS------ILADSHLEMTCNNSFQDKSLRNSPKNEVLHT 1092
            ..|||.|.||:      .:...||:|::      :...:.|..:..|.:|::::.:..:.:   .
  Fly  2366 KSEGHDKESSKYIKKDYDNFDIESELTTSFIMKKVENKAALAKSAENRYQERNMMDQQQQQ---Q 2427

Human  1093 DIMKGSGEP--QPDLQLTKSLETTFKNILELKKAGRQPQSD---------PTVSGSVELDFPNFS 1146
            .|....|:|  |.|.......|....|...::::.:|...:         |....|..||..|.:
  Fly  2428 HIKANGGDPVDQDDGWYCLQKELNLMNNDHMQQSQQQLNGNQQHLPINRQPAPQQSHFLDNSNSN 2492

Human  1147 PMASQENCLEKFIPD 1161
            .|....|.:....|:
  Fly  2493 NMMGNSNHMSDLFPN 2507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BICRAL	XP_047274498.1	GLTSCR1	815..915	CDD:464589	22/107 (21%)
Bicra	NP_001263051.1	PHA03247	<753..1222	CDD:223021	16/86 (19%)
		GLTSCR1	2173..2271	CDD:464589	22/102 (22%)
		SCP-1	<2212..2476	CDD:114219	56/318 (18%)