Protein Alignment DAAM2 and dia

DIOPT Version :9

• Sequence 1: XP_006715102.3
• Gene: DAAM2 / 23500
• HGNCID: 18143
• Length: 1176
• Species: Homo sapiens
• Sequence 2: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Alignment Length: 1207
• Identity: 327/1207 - (27%)
• Similarity: 553/1207 - (45%)
• Gaps: 221/1207 - (18%)

Human    50 EKSMQQGDGLSQHPHPLQSKCPRPISCGMDTDHNEDLGHLSADAPWPAVTMAPRKRSHHGLGFLC 114
            ||:...|.||      |.|...||......|..:..|.|
  Fly    12 EKTKSTGGGL------LDSLFGRPSKSKGGTISSGTLAH-------------------------- 44

Human   115 CFGGSDIPEINLRDNHPLQFME-FSSPIP--NAEELNIRFAELVDELDLTDKNREAMFALPPEKK 176
              ||..:.    .||:.:..:| |...|.  :..||:.:|.|:::::::....||.:.|...|::
  Fly    45 --GGRPVS----ADNYVVPGVEDFEQYIQQLSVAELDAKFLEIIEDMNIPKDKREPLLAKSKEER 103

Human   177 WQIYCSKKKEQEDPNKLATS---WPDYYIDRINSMAAMQSLYAFDEEETEMRNQVVEDLKTALRT 238
            .::.....|.:....:.|.|   .|..|::.:.:          .|..|....|.||.|:.||.:
  Fly   104 QKMIMWHLKGKNSLERSANSRFEKPIDYVEYLQN----------GEHSTHKVYQCVESLRVALTS 158

Human   239 QPMRFVTRFIELEGLTCLLNFL-RSMDHATCESRIHTSLIGCIKALMNNSQGRAHVLAQPEAIST 302
            .|:.::..| .:.|:..:...| ||.::|:.| :|....|.|:||:|||:.| .:|:..|:..|.
  Fly   159 NPISWIKEF-GVAGIGTIEKLLARSKNNASYE-KIEFEAIRCLKAIMNNTWG-LNVVLNPDQHSV 220

Human   303 I---AQSLRTENSKTKVAVLEILGAVCLV--PGGHKKVLQAMLHYQVYAAERT-RFQTLLNELDR 361
            :   ||||.....:|....|::|.:.|:|  ..|::|||:|:......:.:.: ||:.:::.|..
  Fly   221 VLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVLRAITTIAATSFKASERFRPIVDALFA 285

Human   362 SLGRYRDEVNLKTAI----MSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDK----LRQH 418
            |     |:.:.|..:    :.|||.:.|.   ..:|.||||||.|.:.:|:...:|:    :...
  Fly   286 S-----DQQDPKRDLACHSLIFINTLTNT---PTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEAS 342

Human   419 ENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLKYTEAYPCLLSVLHHCL 483
            .|..|.:|...|..:|.:|..|..:|||.|..:...|:..|:::...:..|.:.|..||:|.|.|
  Fly   343 NNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQHLL 407

Human   484 QMPYKRNGGYFQ--QWQLLDRILQQIVLQDERG-VDPDLAPLENFNVKNIVNMLINENEVKQWRD 545
               |.|:..||:  .:||::..:.|||.  .:| .||:   .||.|. ||...|:.::.|::.:.
  Fly   408 ---YIRDDFYFRPAYYQLIEECISQIVF--HKGYCDPN---FENRNF-NIDTSLLLDDIVEKAKA 463

Human   546 QAEKFRKEHMELVSRLERKERECETKTLEKEEMMRTLNKMKDKLARESQELRQARGQVAELVAQL 610
            :..|..:|:.:.:.:||..::|.|.|....||.::               |.:|.|..|....:|
  Fly   464 KESKRSEEYEKKIEQLESAKQEAEAKAAHLEEKVK---------------LMEANGVAAPSPNKL 513

Human   611 SELSTGPVSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFAC---CPPPPPPPLP--PGGPPTPPGA 670
            .:::. |:..|||.||...          ||||||:|...   .|||||||:|  .||||.||..
  Fly   514 PKVNI-PMPPPPPGGGGAP----------PPPPPPMPGRAGGGPPPPPPPPMPGRAGGPPPPPPP 567

Human   671 PPCLGMGLPLPQDPYPSSDVP---------------------LRKKRVPQPSHPLKSFN------ 708
            |   |||.| |..|.|....|                     |:.|:.....:|:|..|
  Fly   568 P---GMGGP-PPPPMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRANWKAIVP 628

Human   709 --------WVKLNEERVPGTVWNEIDDMQVFRILDLEDFEKMFSAYQRHQELITNPSQQKELGST 765
                    |||..|:::..      ||.       |.:....||         :.|.::::..:.
  Fly   629 AKMSDKAFWVKCQEDKLAQ------DDF-------LAELAVKFS---------SKPVKKEQKDAV 671

Human   766 EDIYLASRKVKELSVIDGRRAQNCIILL-SKLK-LSNEEIRQAILKMDEQEDLAKDMLEQLLKFI 828
            :.....::|..:|.|:|.:.|||..|:| ..|| ||.|:|:..:|:.| .:.|:.::|:||::::
  Fly   672 DKPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCD-TDILSSNILQQLIQYL 735

Human   829 PEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLA 893
            |....:..|:|.|.:.|.:...::|...:..|.....||..|.||..:.:.:.:.||.:.|...|
  Fly   736 PPPEHLKRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAA 800

Human   894 SRELVRSKRLRQMLEVILAIGNFMNKGQRG-GAYGFRVASLNKIADTKSSIDRNISLLHYLIMIL 957
            ..|:..||:..::||:||.:||:||.|.:. .|:||.::.|.|:::||.: |...:|||||..::
  Fly   801 CEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDA-DNKQTLLHYLADLV 864

Human   958 EKHFPDILNMPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVEVELEYQRRQVRE-PSDKFVPVM 1021
            ||.|||.||...:|.|:.:|::||:..::|.:..:...::.:|.:|  |..:|.: ..|||..||
  Fly   865 EKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDL--QNNKVPQCDDDKFSEVM 927

Human  1022 SDFITVSSFSFSELEDQLNE------ARDKFAKALMHFGEHD-SKMQPDEFFGIFDTFLQAFSEA 1079
            ..|.       .|...|::.      ..:|..|.|..:...| ||...:|||....||..||..|
  Fly   928 GKFA-------EECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAA 985

Human  1080 -------RQDLEAMRRRKEEEERRARMEAMLKEQRERERWQRQRKVLAAGSSLEEGGEFDDLVSA 1137
                   |::||..||.:|..|:.||      ||:||:  ||::.|:...:...:.|..|.|:.|
  Fly   986 HNDNVRVREELEKKRRLQEAREQSAR------EQQERQ--QRKKAVVDMDAPQTQEGVMDSLLEA 1042

Human  1138 LRSGEVFDKDLCKLKRSRKRSGSQALEVTRERAINRL 1174
            |::|..|.:...:.:|.|.....:..:::|.|:..|:
  Fly  1043 LQTGSAFGQRNRQARRQRPAGAERRAQLSRSRSRTRV 1079

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAAM2	XP_006715102.3	None
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920	49/194 (25%)
		Drf_FH3	253..453	CDD:283917	62/216 (29%)
		FH2	608..983	CDD:280362	113/407 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950