DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MACF1 and shot

DIOPT Version :9

Sequence 1:NP_001380991.1 Gene:MACF1 / 23499 HGNCID:13664 Length:7555 Species:Homo sapiens
Sequence 2:NP_725339.1 Gene:shot / 36542 FlyBaseID:FBgn0013733 Length:8805 Species:Drosophila melanogaster


Alignment Length:9019 Identity:2194/9019 - (24%)
Similarity:3737/9019 - (41%) Gaps:2164/9019 - (23%)


- Green bases have known domain annotations that are detailed below.


Human   176 QISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMER 240
            :||||.: |:..::||:|.||.|.::.||.|.|::..:|:|.|.||..|:||:||.||||:|..:
  Fly   210 EISDIVV-GKEDNVSAREALLRWARRSTARYPGVRVNDFTSSWRDGLAFSALVHRNRPDLLDWRK 273

Human   241 VQIQSNRENLEQAFEVAER-LGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISA 304
            .:....||.||.||.:.|: .|||||||.||||...|||||:|||:||:||.||: |.....:..
  Fly   274 ARNDRPRERLETAFHIVEKEYGVTRLLDPEDVDTNEPDEKSLITYISSLYDVFPE-PPSIHPLFD 337

Human   305 TEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKGRI 369
            .|...|..||:......|.|.::.|..:.:::||...:|:|.|.:....|:..|:.|::|||.::
  Fly   338 MESQRRVHEYRDLAQQFIYWCREKTAYLQERSFPPTLIEMKRLLSDLQRFRSDEVSARKREKSKL 402

Human   370 EELYKLLEVWIE-FGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQN 433
            .::||.||.:.| .|.:.:.....|:.:|:.|.::...:.:||..|:..:||||.|.::|:|:|.
  Fly   403 IQIYKELERYFETVGEVDVEAELRPDAIEKAWYRMNTALQDREVILQQEIERLERLQRLADKVQR 467

Human   434 GALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMY---IQECEGLIRQLQVDLQILRDENYY 495
            ...:.::|||..:..:..:...:|...||..:|.|...   |:..|..|:.:..|..:|.:..|.
  Fly   468 EIKHVDQKLTDLEGRIGEEGRRIERLHPVDAKSIVEALETEIRHLEEPIQDMNQDCHVLNEGRYP 532

Human   496 QLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPPSTLTTTHLKAEPLTKATHSSSTSWF 560
            .:.||..:|.:|......||   ||.:                |....|...|....|.::    
  Fly   533 HVSELHKKVNKLHQRWAQLR---TNFH----------------TNLVQKLSGLKYPVHETT---- 574

Human   561 RKPMTRAELVAISSSEDEGNLRF--VYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTS 623
               :||...:.:.|.:.:.|..|  :.|.:.|.:....:|..|::|:|||||:.:|:.|||.|..
  Fly   575 ---VTRQTRMVVESRQIDTNPHFRDLQEHIEWCQNKLKQLLAADYGSDLPSVKEELDRQQHEHKI 636

Human   624 VEELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAEL 688
            :::..:.:......:.|.|.:....|.:.|.:|:..|.:|..||:.|:..|.||..|:.:|:|||
  Fly   637 IDQFHTKILNDERQQTKFSGDELALYQQRLNQLQKVYAELLSTSTKRLSDLDSLQHFLGQASAEL 701

Human   689 IWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVE 753
            .||||||:.|:..||:|...::.:...|:..|..|||:::..|.::.|..|.|..:.|||.:.:|
  Fly   702 QWLNEKEQVEITRDWADKQLDLPSVHRYYENLMSELEKREMHFATILDRGEALLNQQHPASKCIE 766

Human   754 AYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSR 818
            |:..|:|.|..|:.||.||:|.|:|..|.|.|||.:.::.|.:|....:.:..|:| ..:..|.:
  Fly   767 AHLTALQQQWAWLLQLTLCLEVHLKHATEYHQFFGEIKDAEQWLAKRDEILNSKFS-QSDFGLDQ 830

Human   819 LEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQL-KPRSPDHVLKNTISVKAVCDYRQI-EITI 881
            .|.||:...|.:|:|.....:||:|..|::|:|.| |.|.|   :.....|:|:|.|:|. ::.|
  Fly   831 GETLLRGMQDLREELNAFGETVATLQRRAQTVVPLNKRRQP---VNRQGPVQAICAYKQQGQLQI 892

Human   882 CKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLH 946
            .|.:...|.|||.|.||:|.:..|.|..:|..|.|:|||:::||:.|.|:::.:.:.:|||.:.|
  Fly   893 EKGETVTLLDNSGRVKWRVRTAKGQEGPIPGACLLLPPPDQEAIDAAERLKRLFDRSVALWQKKH 957

Human   947 VNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQ--DSRDSVLFSVAD 1009
            :..:.    |.:...:.:|:.|:.::..:..|.:...|.:.|....:..|.  |..|..|     
  Fly   958 LRLRQ----NMIFATIRVVKGWDFDQFLAMGPEQRTAIRRALNDDADKLLSEGDPNDPQL----- 1013

Human  1010 RLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRT 1074
             .||..|::.....|....|....|::.:..::::..|...|:.:||:..:.:.:.|  ||....
  Fly  1014 -RRLRREMDEVNRLFDEFEKRARAEEESKQASRIFTEECLAIKSKLEDMARELDQII--LAPLPR 1075

Human  1075 DRDAWQ---------DNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSEL 1130
            |.|:.:         :..|.:.|.|     |:.|:.....:::|             .|.|:..|
  Fly  1076 DLDSLEHVLEIHSDYERRLHLLEPE-----LKHLQETFRTIALK-------------TPVLKKSL 1122

Human  1131 NLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTL 1195
            :.|:|....:...|.::.::||.::..:..::|.|.::...|.:|::.:.:.:....|:..:..|
  Fly  1123 DNLMELWKELNTQSGLHKDRLKLLEASLAGLEDNEHVISELENELARHQDLPSTAEGLQQVFKQL 1187

Human  1196 RHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRL-TPERNL-DLERYQEKGSQLQERWHRVIAQL 1258
            .|       ...:.:....::.|....|:|:.|: .|.:.| ||:|......:|..||..|..||
  Fly  1188 NH-------MQDIITQQQPQMDKMNDAADQLGRMGVPTKVLGDLKRLHSNVERLNTRWSAVCNQL 1245

Human  1259 EIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIER 1323
            ..|....|:...::.:.::.......|::.||.:...|.  .|..:..|.:.|.      |.|||
  Fly  1246 GERMRSCETAIGLMKNLQSSVQVEESWVDGTTERLSAMP--TATSAYELDKLLG------AAIER 1302

Human  1324 NQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDA-------ITQEFM 1381
             :.|::.......:.....|.|:.:.:.:..::...:.|....||.|..:|:       .:|...
  Fly  1303 -KPKIENVNVAGGRLIREAKIYDSKCLRFVDWLVEARPSFSPPRRDLRPADSDPGATQYYSQRLD 1366

Human  1382 DLRTRYTALVTLTTQHVKYI-----SDALRRLEEEEKVVEEEKQEHVEKVKELLGWVST----LA 1437
            :|.|:...|:...:|.:|..     ||.|:..|..:|.::      ..:|....|.|.|    .|
  Fly  1367 NLNTKNDRLLEQLSQRLKTAIEVNGSDGLQYAESLQKPLK------TFRVDFSAGSVPTGDGYAA 1425

Human  1438 RNTQGKATSSETKE--STDIEKAILEQQVLSEELTTKKEQVSEA-IKTSQIFLAKHGHKLSEKEK 1499
            |......|:..|.:  ||...|:..:....|:.|....::||.| :..|||       :.:|...
  Fly  1426 RQEDLYTTTYSTTQISSTKTTKSSTKSVYSSDGLDAASQEVSTAGLPQSQI-------QFNEIRT 1483

Human  1500 KQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKECRAVAGVIDLGTVEIFPIFKAMQKG 1564
            .:.|:||..     |.:.|                        :||:.|..|..:..|.:|:|..
  Fly  1484 LKRSQQLGG-----HSVLD------------------------IAGIRDPRTGRVLTIGEAIQLR 1519

Human  1565 LLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQL-----------RELQDA 1618
            :||..||.:|:..:             .::||:...:.||:.|:.:||           ||| ..
  Fly  1520 ILDVRTGEMLVGDR-------------RITLEQAADQGLIDLQLAKQLLEPGAGRDASGREL-SL 1570

Human  1619 LALISR-LTESRGPLSVVEAIEKRI-ISETVGLKILEAHLATGGFSLSPSENCINLEEAFHQGLI 1681
            |.:|.| ::|:.   |..|..|||| ::.||.::      .|.| .|...||..|:.:|...|.:
  Fly  1571 LEVIQREISEAE---SGYETAEKRIKVNNTVTVE------QTSG-ELGSPENPRNIADAITAGSV 1625

Human  1682 ----------SAWLHSVLESYLR---------TSKN-------------------LIDPNTAEKI 1708
                      |....|:.|:|.|         |.|:                   :.|.|:.:|.
  Fly  1626 DTKTGLYRVKSGQTISLAEAYERGYLIRHESVTIKSNALCLSDAIAHGLVDGAGWIADRNSGDKF 1690

Human  1709 --------GLLDLMQRCIVHQESGFKLLPVKQLAGGMVSLKSGR--------------------- 1744
                    .|:|...|.:|..:...|:...:.|..|:::.|:||                     
  Fly  1691 RLDSAIANQLIDASVREVVDAKRDTKITLQEALQSGVLNAKTGRYVNEVTKEKLTFAEARNRQLI 1755

Human  1745 ----------------------------KVSIFRAVQEGLIDRQV----------TVRLLEAQLF 1771
                                        |:||.:|::.|::|..:          .|.|.||  .
  Fly  1756 VKPYTLKDICDLNLLDKQAQITSPMRREKLSIMQAIEAGVLDGNLLKCITKRKGELVTLQEA--I 1818

Human  1772 AGGIVDP--------RTGHRLTVEEAVRHNLIDQDMACAI------------------------L 1804
            |.|||.|        .||..:::.|||...||......:|                        |
  Fly  1819 ADGIVLPAECKYRDFMTGELISIPEAVERGLISSVAQRSIFDIDGFKDLRSNDYVSFNVALSRDL 1883

Human  1805 IRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKI----------------ALVILESLWSFM---- 1849
            :|:..||..::|.....:.::.|||..||..::                .|.:.:.::..:    
  Fly  1884 LRRKSTGFALETGRDSLVPLEVAVSEGLVRQEVYEMFSRGIGVQNASGKELSVFDLVYHNLIDPK 1948

Human  1850 --GLLWPESGEILPITDALEQGIVSTELAHKILSNRQHIKALFLPATTE---------------- 1896
              .||.|::||.:|:..|:|:..::.|.| .:||:     .|.:..|||                
  Fly  1949 TGYLLDPKTGETVPLDTAIERKFITPEGA-LLLSS-----LLNITLTTETVTRTINRYVTIRAGS 2007

Human  1897 -------ILSWKKAIESGILD--RDLANNLKSICIPDVMPHMQLADSAEQNINPGAAVLPCSKSH 1952
                   :|::.:|:..|.:|  |.|..:.|:..|          .|.:|.:|.|..|...:::.
  Fly  2008 QEPVDSVLLTFTEAVRQGFIDEERQLFKDPKTGNI----------YSVQQALNYGLLVPDSNQTV 2062

Human  1953 PKATASQSENLLFQLMTHSYINVQNGQRLLLLDKELMETLTSRDEYQTSPPKVVE--IGHQRQKT 2015
            |:.|..:.        |.|.|.:...|  ::.:.|.::..|...:|   ..|.||  |..:..|.
  Fly  2063 PEPTNRKK--------TKSTITIVTKQ--IIPEAEPIKLNTQHTKY---VEKSVEIPISQELVKP 2114

Human  2016 PEGLQESANVKISGTFSSGWTVRLPEFQFSSQNKEYPDREDCTTEKGKKTTVETEDSSVENPEQD 2080
            ...:.|..|::.|.......|.|        |..|.|        .|.....:..:..:.||:..
  Fly  2115 HRVVSEFINLEKSSYIEQNVTER--------QIMELP--------PGGWRLKDAIEQRLFNPDTG 2163

Human  2081 LF-VEQKERNPNIDAL---KVINKVKLEV---------------QRQLI---GTQREDQTAVSVR 2123
            :| |:..:|..|.:..   ::||.:.|.|               :|.::   |.....:..|...
  Fly  2164 VFHVQGTDRLVNFEECINKQIINNLSLSVIDPNTGDKISVQSAFERDILDSYGNYTNSRKQVQGM 2228

Human  2124 ENA---SRGHLLTIPP------------AEAEGVPLVVDKDVFSVETPKKEHQPLRNTSFTCQNE 2173
            .:|   |:..|.|:|.            .:...:|     ||..|.||.|:..|......|||.|
  Fly  2229 RSAIDESKIILETVPATRGANQKTILRITKVNNIP-----DVLEVSTPLKDAPPKFVEVLTCQRE 2288

Human  2174 QAHTLETEYIHDETGGSHIKPQSKKLQVQVKKTLGIKLELKSETDGNVHPLDKKEMLKKTFLAKD 2238
            .|                                                               
  Fly  2289 LA--------------------------------------------------------------- 2290

Human  2239 DHKESQEAQNIAGGSMMMSEKTDEEDSGREIFLSCSHPLELLEEATLNVLSAQLLDGGIFHEQTG 2303
                |.|...||.|::.      :..:...||........:.:.|...::..||:.  |....|.
  Fly  2291 ----SPEPLQIAPGAIY------DPSTALVIFTQTGETENIFDAARQGLVDEQLIK--IVDPTTK 2343

Human  2304 QKLLLNEAISRGIVPSHTAVKL-----------MEKLNMF----------QGFF-------DSQT 2340
            |.:.:.|||:|.|....||..|           ..||.:.          :|..       |.:|
  Fly  2344 QPISVTEAIARSIYDPKTATILDSEGQPVDLITATKLGLLSVVGAPLVAAEGALRTVRFVTDPRT 2408

Human  2341 CESLTTEEVINEGLMDEKLLHN--------VLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKET 2397
            .|.:..|.....|::....||.        ..:.||.:  ||....:.:...|||:..|::|:||
  Fly  2409 GEQIPVEVAYERGIVSRDQLHRGRSFDSEPATVEDKVV--VLQRMRKVILKPKDALRKGIIDEET 2471

Human  2398 ATRILERQVVTGGIIDLKRGKKVSVTLASTLGLVD-----VADQPE---LINLEKASKGR--DAE 2452
            . .|||.   |....:.| |:.|::|.|...||:|     |.| |:   ::||.:|.:.:  |:|
  Fly  2472 C-EILEN---TSNFTNPK-GEVVNITEALNTGLIDGRRGQVID-PQNNRVLNLRQAVEQKIIDSE 2530

Human  2453 KT------VRERLISLQMETTGLID--------PDSKAPLTVVQSI------DRGLLEREEAVRL 2497
            :|      :.:.|...::...||||        |:|..||::.::|      ....|.:.|...|
  Fly  2531 QTNHILMPLAKSLSVPRLADQGLIDPQTQTIVHPESGYPLSIHEAIVCEVLDPHSKLHKPEKCTL 2595

Human  2498 LTKQVVDGGIIH------HISGMRLSVDNAFRHGLIGEDLAEKLKRVENLNIHQIF--------- 2547
              ::.:..|||:      :.....|::..|....|......::..:||...:..||         
  Fly  2596 --EEAITKGIINADDSTFNYKNKTLNITEAIEAKLFDPSYDQQKSKVEIPPVGMIFPVAVEKSLV 2658

Human  2548 --------NPETKENISLPKAIKLDLIT----SDLKREIQEVQAFTGNFVDLI--------SGQR 2592
                    :|.||:.:.:.:||:.:.|.    |.....|:.|.|...:.:|:.        :|:|
  Fly  2659 EPSKRVVLHPSTKKALPIKQAIEENFIMSIPYSPKPDAIEVVTAMEQDLIDVAAQTLTVPSTGER 2723

Human  2593 LTLAEAKKEGLLT----NEAVLSPGMMHGIVDPENCRIVPYSELVKKCKI-------DIESGQRY 2646
            :.|.:|.:.|:|.    ::.|::.            :.:|.:|:::..:.       .||..|.|
  Fly  2724 IPLRQAMENGVLVVKNLSDFVITQ------------KPIPKTEIMETVRAVHTVTTKTIELMQGY 2776

Human  2647 LEVIPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLKVLEAQA----------NTGG--------- 2692
            : :|..:::::..:.:|.:|.:|.:||.:...||.:..:|.|          .|.|         
  Fly  2777 V-LISNNEVQNVNTGEVCSLEEAKELGILREESTTRETKAAAGESPESVGDVGTSGDQTVIVEER 2840

Human  2693 ----IIDTATGKR---------------LTLASALEEKLVDE--------------NMVRIIASH 2724
                ::.:.|.|:               :...|.:|.|...|              ..:.:||:.
  Fly  2841 TQTVVVSSDTRKQEMQVVSTTQSTKDTSVPSVSEIETKGSKEPSKTLQNVKDAAKLGALGVIAAP 2905

Human  2725 QVLNGGIV---------------DIFSDQR-----VTLVEAIEKRLISP------------ELAN 2757
            .:..|.||               |..|.::     .:.:|...::.:.|            |..|
  Fly  2906 VLAGGAIVSGVKSLIKSVKSPTEDAKSTEKPKEPQTSFIEQERRKELQPQQVPSEVDNLLSETEN 2970

Human  2758 MIQIDSSEFSDHRAQIEKQ--------------------------------------------EG 2778
            .|...::.|..:..|.:|.                                            |.
  Fly  2971 FISSTTANFIANEKQQDKPDTLPQESNLPLEVESTSTLTTTTVTTITTSSTTTETGNLEPVVVED 3035

Human  2779 IEVCALQNEFLGKDMLIACNQTAEMSCNKVEES-ERLFQVENQSAQEKVKVRVSDGEQAKK---- 2838
            :.....:::.:.|...:..::| |:|  |:.|: ..:...|..:..||:..:.:..|.|||    
  Fly  3036 VSTTVKEDKVVVKPSTVPEDKT-EVS--KITETITTVTSNETDTVPEKISQKSASEESAKKDPVV 3097

Human  2839 -----SR----EISLK--------------EFGCKDQRKPRMSSDAKEFISII------------ 2868
                 ||    |.|.|              ||....::.|....|.||..:..            
  Fly  3098 TKDTSSRPAETETSPKPVQKEPTPDPAQNTEFPESIKKDPTPEPDYKETATEAAQITPKEASPAP 3162

Human  2869 ----------------NPHNLKGKSLGQVS--LTHP------------YSECDFKLKEVARNNMG 2903
                            .|...|.:.:.::.  .|.|            .:|...:.||...::..
  Fly  3163 TNKNEQSAEPTSKPEPMPRTAKKEEISEIEPPFTAPLAPFVDQLAETKITEIKTEFKEPVTSSQT 3227

Human  2904 NDTNEEQEKAVTK---IEIISHMKQSTSCLDSEEIRENQGEVILEVQETYCETSGKLP------- 2958
            ..|.....|.|.:   :|.:..:.:|...:|.||...:|.|.| :|.||..:::...|       
  Fly  3228 ITTITTTVKTVDEHPIVEEVDEVSKSEKIVDVEEPTVHQQEPI-KVNETSDDSTRTEPTNEIVHE 3291

Human  2959 ----------------------------SEQVLQQ---------PMNARVKSK------------ 2974
                                        ||:.|.|         |:|..|.|.            
  Fly  3292 ERVVTVEEPTITETTVTTTTITTTTTSSSEETLPQENTATVKETPLNEPVPSSPAETKEIEQTTN 3356

Human  2975 --REKREVIVE-----------ESIRTCKPAFLSEE---KLYQETAIRDEHDSHIKS------QP 3017
              ::|.|.||:           |:|.| :|...||.   .|..:|.|.||...|..|      ||
  Fly  3357 DDQKKPEEIVDTEKKTTEQKPVETIPT-EPISTSETTTVTLTTKTTIVDEGKLHPPSDIEQIIQP 3420

Human  3018 R----------EMTSSEKGKEADTEMGFSITFKIEESSSQVVPQGISVKHLDALTLFSSK-QANE 3071
            .          :....|||.: ..|.|.:|...:::::.           |.||.:..:. .|.:
  Fly  3421 HSTSDKHQSLVDFIEQEKGTQ-PAEGGSNILQNVKDAAK-----------LGALAIVGAPVLAGK 3473

Human  3072 GKVNNLSLCLTLKPEENLSREIACGAQSEPFPCMTPRPEGLHYQESDGKAQVTGPSQISKTDKSF 3136
            ..|:.|:...|||||.:.|:.:....:..|...:|.....|       ..:||..:..:.|..| 
  Fly  3474 ALVDALTTEKTLKPEHSTSQVVTETVEELPTEIITTSTATL-------VTKVTTTTTTTTTSTS- 3530

Human  3137 QGTTRQE--------TNYQDSWVTSKTKET-------KHQISSSNEC-----------------K 3169
            :||...|        ....:|.|..:...|       ..::.|.:||                 |
  Fly  3531 EGTPDDEALDVVKLPAELVESSVKREVPRTLAIGDAISQKLISPDECQVIVDGEQQSQTVSTLLK 3595

Human  3170 EKS----------------YQEVSF---------------------------DPARGLKLE---- 3187
            |:.                .|:||:                           ||:.|.|:.    
  Fly  3596 EEQLSPLDEVQIIDDKLIVLQQVSYLVDADTELTPQNLYELNIYDPENQYFIDPSTGQKISFHTL 3660

Human  3188 --EITVSRPDS------------------------------------KEVRYLEFSDRKDLHHQG 3214
              ::.|..|::                                    |::.:.|..||:.:....
  Fly  3661 VFDMNVFNPETILVKNFSTGKYETLTAALERPLLDRHTGHMVDPKTGKKIPFFECVDRQWIIRAN 3725

Human  3215 SK---------------------SDDKLCGTLKS---------EIATQE-LTGEKF-LEMA-NPN 3246
            .:                     .|.::|..:::         .|:.:: ::||.. |.|| ...
  Fly  3726 PEEQKPSGIENVTIDTQTGQVVLDDGRVCSIVEAINSGKLDIQSISVRDPVSGEVIPLRMAIELG 3790

Human  3247 VAGLEAGSIEDIVT----------QRGSRVLGS--------------FLPE--KLFKGVSQ---- 3281
            |..::||::.||.|          |.|..|.|:              :.||  |||...||    
  Fly  3791 VVDMQAGTVIDIQTLKEIPMELAFQLGFLVPGARKPISLEAAVRKGLYDPETGKLFDSESQNQVD 3855

Human  3282 -----------------------------------------------KENT------GQQNAIIS 3293
                                                           |.||      |.|..::.
  Fly  3856 VQKSIEIGLVDPKISLIVDTVTKKEVKLDCAIEDDLVLPATGQIKDNKNNTLVPFDVGVQQCLLK 3920

Human  3294 --------PTVLE---------------TSEE--------------------------------- 3302
                    |.:|:               |.||                                 
  Fly  3921 TDNVTWSLPELLQREYYTPSTGKVLNPVTGEEILLQQAIEMGFVELETTLVKDVDHDKILPGKEA 3985

Human  3303 ---------------------------------KTVSLTVC----------------------SA 3312
                                             |.:||..|                      .|
  Fly  3986 AKVGLLDTVRGTLSSPNISLDEAFVKGYLISTKKPLSLVDCLLRGLYDPSTAKFTIDDKQLDLKA 4050

Human  3313 VKTEK--TPQEKLRESPGSEQTPFMTAPEGKGNGGVNP------EPFRATQ-------------- 3355
            ...:|  .|:|.:...|.:|.  .::..|....|.::|      .|:.:|:              
  Fly  4051 AIAQKLINPEELVLLDPKTES--IISITEAIAKGYLDPIEGYVINPYASTKLSLHEALENRILIP 4113

Human  3356 ------------------------NVFTRQLCLEHDEKLVSYLSLLRNI---------------- 3380
                                    |..||       |||.:..::.|.|                
  Fly  4114 PKRKRSLPDAVYRGLYDPKTGQFSNTVTR-------EKLTTERAIRRGILDPDSTVVNVGSGQII 4171

Human  3381 ----------------EMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQEL------- 3422
                            .:|.....|::...|..:.:|.:||...|.::.:...|..|:       
  Fly  4172 PFGVATETGIVDSKHGTVRDADDHPIDFKEAFDRGILVEAKKPLRLIEAVVKNVYDEVDGHFVDP 4236

Human  3423 ---------ECVNQIIIS----QPQEVPAQLLKALE-KDAKNLQKSLSSVSDTWNSRLLH----- 3468
                     |.:|..::.    |.::....|.|.|. ..||:     :.:.|..||:||:     
  Fly  4237 KSGEKLNFAEALNTNLLDEHSVQIRDFKTGLYKQLNLTHAKD-----TGIIDAQNSKLLYNNQTM 4296

Human  3469 -FQNAVEI----------------------EKT-KVLNQHTQLEGR----LQDLRAWVGN----- 3500
             .::|.:|                      :|| |:.:..|   ||    |:.:|::|.|     
  Fly  4297 TLKHAFDIGILMDVNAPISIQRAIHQGLFDDKTGKLSDPRT---GRQITLLESMRSFVVNPHLPC 4358

Human  3501 ----------------KNLILNSK-------GSNSEID----------VDSLNLCLQQYEDLK-- 3530
                            :|.|:|.:       ||||.:.          ||..|.....||.|.  
  Fly  4359 YFDEQTEQMYTLSETCRNGIINRREGVFREPGSNSFVPLGEALSLGLIVDIENAGFGLYELLSMG 4423

Human  3531 ----------QPMAERKAQL-DALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDIL--- 3581
                      .|:..||..| :|...|:   :|..:..:...:..:.|||.|.::....|..   
  Fly  4424 FYETSTRKVLHPVTNRKLNLNEACVEDV---VSLSSSLVKHHETGKYLRLANAIKEQLVDDSRGC 4485

Human  3582 -----EQTAAQVDALQGHLQQMEQEALVKTLQKQQ-----------NTCHQQLEDLCSWV--GQA 3628
                 ||...|....:|.:....:...::.:.:||           .|..:.| ||...:  |..
  Fly  4486 YNLGNEQLDLQAARARGLIVSNRRLLSLELVLRQQLYRPETGKFCDPTTGEYL-DLIEAIHSGFI 4549

Human  3629 ERALAGHQGRTTQQDL---SALQKNQSDL---------------------KDLQDDIQNRATSFA 3669
            :.|....:.:.|.::|   .|::....|:                     :.:...|....|...
  Fly  4550 DPATTVFKNQLTGKELPLTEAIENGDIDVSKGRVFDPKSKSAYNYDVALSRGILVTITRPLTDRN 4614

Human  3670 TVVKDIEGFMEENQTKLS-----PREL--------------TAL--------------------- 3694
            .||:..:.....|||.:|     |||:              |||                     
  Fly  4615 DVVRRQDSVELLNQTPVSVVISKPREMSLEEAIRYNIIDPKTALVRDFDSFKFLPYSVAVERGLV 4679

Human  3695 ---REKLHQAKEQYEALQEETRVAQKE-------------------------------------- 3718
               :..|...|..|.|......|..:|                                      
  Fly  4680 DTTKRTLVDPKALYFAFDPTLIVYVREPVTFDQAAESKCLDLQTGLLTYVPASVPGSATAAPASD 4744

Human  3719 -----------------LEEAVT-------SALQQETEKSKAAKELAE---------NK------ 3744
                             |:||.:       |||.::..|:|..: |.|         ||      
  Fly  4745 DSANDSLTVIETPKVYTLKEAASAGVVDPDSALVKDLAKAKLVR-LPEAFRKGLMDANKANVLNT 4808

Human  3745 --------------------KKIDALLDWVT-------------------------------SVG 3758
                                |:...||:.:|                               ::|
  Fly  4809 QTSKLCTLQEAYESGLICTPKRSFGLLEAITFNLYNPTNGCLVDPFQMHPDIIRRRKFTLAEAIG 4873

Human  3759 S-----SGGQLLTNLPGMEQLSGASLEKGALDTTDGYM--------------------------- 3791
            |     |...:.....|:.....|::..|.:|.|:|.:                           
  Fly  4874 SGLVDPSSTVVRDPSTGVIVPLTAAISSGLIDATEGRLTDANEPKNNIDLVKAAEKGLLLPAEQR 4938

Human  3792 -----------------------------GVNQAPEKLDK---QCEMMKARHQELLSQQQNFILA 3824
                                         .|....||:|:   |...:|....|:.|||:.....
  Fly  4939 QAVFEKFNMCEENVNDLLKWVTTVEQKISSVGGPREKIDELRNQINALKQIKDEIESQQRPVATC 5003

Human  3825 TQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEF 3889
            .:..:..:...|..|:..|...|:....||:.:......::...|::::..:|||.|...:...|
  Fly  5004 LEQIRQIVLTGGDVLSAPEVTTLENSGRELRSRVDRVNDRTVRLLRRLEAGRDELTKLRSELDVF 5068

Human  3890 ESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSF--- 3951
            ..||:.:.:.||:..:..|....|||.......|..|||.|:.||||:|::.||.:|....|   
  Fly  5069 SDWLQVARRTLEDKERSLSDLTRLPSQADSVREFVSDVIGHQADLRFITMAAQKFVDESKEFLAI 5133

Human  3952 ------------------KEGKEP--SEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQY 3996
                              ...:.|  .|: :||..:.||...|..||..:.:.||       |:.
  Fly  5134 LNDFRTSLPERLPHVEPLSSAESPIRQEV-SLVSAQYKDLLNRVNALQDRVSGLG-------GRQ 5190

Human  3997 HQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR 4061
            .::|::.|....|:::....|.:::|:.:|.||..:|:|:...|.|..||......|:..|:...
  Fly  5191 REYQDALDKANEWLRSVHPRVSRIISEPIAGDPKGVQDQMNEAKALHNELLSSGRLVDNAQQALD 5255

Human  4062 DIM-EIEGEPAP-DHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIG 4124
            ::: .:.|:.:| :...::.....:.:::|.|..:|.|....|.|.:.|||.||::|:||:..:.
  Fly  5256 NLLRSLGGQLSPMEINQLELPIADLKNNYQQLLDNLGEHCKTLDKTLVQSQGVQDALDSLVGWVN 5320

Human  4125 EVEQNLE-GKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETA-DSTTAAVLQ 4187
            :.|...: ..:.:||....:||.:..:..|..|:...::|:::.:......:.:| ::..|..::
  Fly  5321 QAEDKFKMNLRPASLIKERLQEQIREHKVLLADLQSHQASIDSVQVSAKHLLASASNARIAKKVE 5385

Human  4188 GKLAEVSQRFEQLCLQQQEK-------ESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQP 4245
            ..|.:|:.:||:|..:..::       .:.|.:.|.:....|.....||:.::::...|.|..: 
  Fly  5386 SNLNDVTVKFEKLYEKANKRGEFLDDVYNRLSRYLDEISTVEQRMASLQEALDSRETSLLSTEE- 5449

Human  4246 DQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTV 4310
                  ..:::.||:.:.:......:.......:|.|.....|....:||::.|...:..:..::
  Fly  5450 ------LARRMNELSRDKDQLAPQFEDCVRSGKDLISLRDVTDTGVLRDRIKALESQWRNINISI 5508

Human  4311 KEREKDASSCQEQLDEFRKLVRTFQKWLKETE---GSIPPTETSMSAKELEKQIEHLKSLLDDWA 4372
            .||.|.:....||...:..|......||..||   ..:||  .::....:::|.:.||.:..|:.
  Fly  5509 DERAKLSKQKAEQQLAYEGLKDQVLSWLASTEARVNGLPP--VAIDLDRIKQQHDELKPICKDYR 5571

Human  4373 SKGTLVEEINCKGTSLENLI--------------MEITAP----------DSQGKTGSILP-SVG 4412
            .....:::||..|...:.||              ::.|:|          .|..|.|.:.| |.|
  Fly  5572 DYAPTIDKINDIGAQYDALIRPESPARKRSTYSPIKRTSPLRRMSGDARSPSPTKGGILSPLSTG 5636

Human  4413 SS-----VGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSV 4472
            ||     ..|.:|:. ..:|:.:|..:|::|.:|..:|..|::||..|..:...:.:.::....:
  Fly  5637 SSGFGSRRSSQDGFQ-LSELSPVQQQLSEINNRYGLIGVRLNDRQHELDNLNEELRKQYENLKGL 5700

Human  4473 LQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQ 4537
            .|:||..:..|.. :::|:..:.|....||   :..|.::.:....:...|..:..:|....:..
  Fly  5701 AQFLERIQRQLPK-ESVSNKDEAERCIKQA---RKILEDMYEKQSLLDTTKAQVKDILRRKSDVP 5761

Human  4538 EAENWKKIQEELNSRWERATEV---TVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLG 4599
            .||..::..:.:..:|:...::   .:|...:|.:       |......|:.||..||.|:.|||
  Fly  5762 GAEQLRQENDSIQEKWKNLNDICKNRIAFSEKLRD-------FLDTHGNLKSWLDSKERMLTVLG 5819

Human  4600 PLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGI---LTGPGDVSLSTSQVQKELQSIN 4661
            |:|.||.|:.:|.||||.:.:||..::.|.:...|....:   |.|..|    ...|:.:|:.|.
  Fly  5820 PISSDPRMVQSQVQQVQVLREEFRTQQPQLKHFQELGHDVVDHLAGTPD----AQAVEIKLKDIL 5880

Human  4662 QKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQP---------- 4716
            .||.:|..||:.|::.:..|...|.::...:..|.|.::.:...|      .|.|          
  Fly  5881 GKWDDLVGKLDDRANSLGGAADSSKEFDAAVNRLREALQNISDNL------DTLPTDGDHQENLR 5939

Human  4717 --EAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLED 4779
              |.:::|||....:.:|:||      .|.|||:    ::|:...:.::..|:..:......|:.
  Fly  5940 KIENLERQLEGQRPLLADVEQ------SAATLCN----ILGDPASRADVNSRVAALEKQYLALQK 5994

Human  4780 LAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN 4844
            ....:....:|:|...:.|.:...:...||..:.|.......:||....||.|:..:|...:   
  Fly  5995 KLDTKKAETEASLRDGRHFAENCSKTLGWLGGELSNLTDRLLVSAHKPTLQHQIDTHEPIYR--- 6056

Human  4845 QHSGSYEVIVAEGESLLL-----SVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQK 4904
                  ||:..|.|.::|     .:...::.|.::..|..::..||:|.::..||.:||:.||:.
  Fly  6057 ------EVMAREHEVIMLINKGKDLTDRQQDRGVKRDLDRIQQQWEKLRREAVDRHTRLQTCMEH 6115

Human  4905 AQKYQWHVEDLVPWIEDCKAKMSELRV-TLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADI 4968
            .:||....|..:.|:...:.|:::|.. .|...:||:.|...:...:||.|.....|......:.
  Fly  6116 CKKYSQTSETFLAWLRTAEDKLADLTPGVLSKAKLETRLRDLQTFRSEVWKHSGEFENTKGLGET 6180

Human  4969 LINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQL 5033
            .::|.:.|::.|:.|...|....:.:..:|.|:...:|..::||.:|.:..:|::..:...:.:|
  Fly  6181 FLSSCDIDKEPIKAELQDIRDRWERLNNDLIARAHEIENCSRRLDDFNDELRNLDHSLGRCEDRL 6245

Human  5034 EIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDA-PDGSDASQLLHQAEVAQ 5097
            ...||||..|...|.||:::|.:|.|..|...:..|:...:.:..:| ..|.||..|..:.:...
  Fly  6246 AAHDALGGAAKDPKLLERVKAIREELTNLSKPLQSLKALAKDISAEARAAGGDADHLTSEVDGLA 6310

Human  5098 QEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDV 5162
            ....|::.|::..|..:::....:.||:.:::.:...|.||:.|::.:...||:...:|.||:||
  Fly  6311 DRMSELQGRLDDRCGELQSAATAVSQFNEQMKSLGIDLNDLETEIEKLSPPGREIKIVQVQIDDV 6375

Human  5163 RLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTL 5227
            .....|:..|...:|.:|.....:::.....|....:.::..|.|..|:|..|.:..::.|..||
  Fly  6376 GKIQTKLDRLVGRLEDAERAADVLVDAGFAADTTQTREQISTLRKTLGRLDNRVRDHEDNLHSTL 6440

Human  5228 GRVEDFY-RKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNG 5291
            ..:.:|| .:.:.|:|....::|.:.:: .||:|::.|.:|..||:.|::.:|:||.:.:.:||.
  Fly  6441 KALREFYDHQSQTLDDIQDVSDEFKRMK-PVGSELDQIRRQQEDFRNFRERKVEPLAINVDKVNV 6504

Human  5292 LGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLA 5356
            .|:.|::|||.......:|.|:|::|.|||.|.:::.:|..:|..|||..||||:||..|..||:
  Fly  6505 AGRDLVRSAGSGVSTTAIEKDLEKLNDRWNDLKERMNERDRRLDVALLQSGKFQEALAGLSKWLS 6569

Human  5357 DTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQ 5421
            ||||::|||||||::|||||||:||||.|:::|.||:.::..|...|..:|...|..:|..|..|
  Fly  6570 DTEEMVANQKPPSSDYKVVKAQLQEQKFLKKMLLDRQNSMGSLANLGKEVANHCEPGERASIEKQ 6634

Human  5422 LESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQ 5486
            |..|..|:..|...|..|:..||:.:.:||:||:...|:..:|..||:.:...|.:.|...||||
  Fly  6635 LNDLMKRFDALTDGAEQRELDLEEAMEVAKRFHDKISPLELWLDNTERSVKAMELIPTDEEKIQQ 6699

Human  5487 QIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAAL 5551
            :|..|..|.::|.....|......:...|..|.|..|...|.||:..:..||:.:.|......||
  Fly  6700 RIREHDRLHDEILGKKPDFSDLADVTAQLMHLVSDEEAVNLGEKVRGVTERYTGLVDASDNIGAL 6764

Human  5552 LDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHR----QHADH-LALNEEIVNRK 5611
            |.::....|.......:::.|:..:|.:|     |.||...::.    :..|| |.|||.|....
  Fly  6765 LAESRQGLRHLVLSYQDLVAWMESMEAEL-----KRFKSVPVYAEKLLEQMDHLLELNENIAGHA 6824

Human  5612 KNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYE 5676
            .||:..:::|..|:|..:.:|.:.:::|||.::.||.|:|......|::.:.|..|..:|...:.
  Fly  6825 SNVESTVESGAELMKHISNDEAIQLKDKLDSLQRRYGDLTNRGGDLLKSAQNALPLVQQFHEAHN 6889

Human  5677 ELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKE---LKKEVMEHRLVLDTVNEVSRALLELVP 5738
            .|..|::..|..||.|             :.||.:   |:.|:.:.|.:||::|:|...|.:|.|
  Fly  6890 RLVEWMQSAEAALAPS-------------EPRQADVLRLEGELADMRPILDSINQVGPQLCQLSP 6941

Human  5739 WRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGP 5803
            ......::.:|:..|.::..:.:.|.::.:.:..:.||:::.....|..|.|..|....|.....
  Fly  6942 GEGAATIESIVTRDNRRFDSIVEQIQRKAERLHLSNQRAKEVTGDIDELLEWFREMDTTLREADL 7006

Human  5804 IRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKT-VLQEKTESLIQQYEA 5867
            ..:|.....||||..::.:.||...|..:.::.:...::.....:.:.| .|:||.:.|.:..:.
  Fly  7007 PAMEPKLVRAQLQEHRSINDDISSQKGRVRDVTAASKKVLRESPQSENTATLREKLDDLKEIVDT 7071

Human  5868 ISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRE 5932
            ::.|.|||...||:|..|...|.::::.|:.|:::....|::|..||:..:|:..||::..:|.:
  Fly  7072 VAQLCSERLGILEQALPLSEHFADSHQGLTAWLDDMEQQISRLSMPALRPDQITLQQDKNERLLQ 7136

Human  5933 SIAEHKPHIDKLLKIGPQLKEL-NPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQ 5996
            |||||||.:|||.|.|..|..| ..::|..:.|........||.::.|:|:|..||:.|:.:|:|
  Fly  7137 SIAEHKPLLDKLNKTGEALGALVADDDGAKINEILDTDNARYAALRLELRERQQALESALQESSQ 7201

Human  5997 FHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIG 6061
            |.||:|.||..|.|...::.....:.|...||||.|.||.:...:|:|.|.:|.|::|...::|.
  Fly  7202 FSDKLEGMLRALANTVDQVNQLDPLSALPQKIREQIEDNDALMDDLDKRQDAFSAVQRAANDVIA 7266

Human  6062 RSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQD 6126
            :: |...|.|.::|:.||:::...|.|::...::|.....|:|.:||.||..:.:::.|:||.::
  Fly  7267 KA-GNKADPAVRDIKAKLEKLNNLWNDVQNATKKRGSSLDDILSVAEPFWKQLNSVMKTLKDLEE 7330

Human  6127 IVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEM 6191
            .:...|.|...|..||:|..|.:.|:.|.|....|:|.:|..|::|:..|||.:||||:|.|:::
  Fly  7331 TLSCQEPPAAQPQDIKKQQVALQEIRHEIDQTKPEVEQVRRHGSNLMNMCGEPDKPEVKKHIEDL 7395

Human  6192 NNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE 6256
            :|||:|:...:.:|.|.|.|||:.|:::.:|||.:..:|.....|...:..||:|::.||.|:.:
  Fly  7396 DNAWDNITALYAKREENLIDAMEKAMEFHETLQNLLKFLTKAEDKFAHLGAVGSDIDAVKRQIEQ 7460

Human  6257 MKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEG 6321
            :|.||.||....:|:|.||.|. :.|.:.|.......|||||:.:...||.|...:..||.:||.
  Fly  7461 LKSFKDEVDPHMVEVEALNRQA-VELTERTSPEQAASIREPLSVVNRRWEALLRGMVERQKQLEH 7524

Human  6322 ALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNK 6386
            |||.||||||||.||:.|:..|:..||..:||.|||:::||||||..||.||:.|||.:|:|:|.
  Fly  7525 ALLHLGQFQHALNELLVWINKTDSTLDQLKPIPGDPQLLEVELAKLKVLANDIQAHQNSVDTLND 7589

Human  6387 AGNELLESSAGD-DASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELT 6450
            ||.:|:|:..|. :||:.:.:|..:|..|:.:|||..:|:.:|:..|::|.|:.:|::|.|..|.
  Fly  7590 AGRQLIETEKGSVEASTTQEKLRKLNNEWKQLLQKASDRQHELEEALREAHGYIAEVQDILGWLG 7654

Human  6451 RMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDD-SGSGSKTE 6514
            .:::.:.||||.|||||||.|||:..||:|::|.........:..:|:..:..::. ..|.|..:
  Fly  7655 DVDAVIGASKPVGGLPETATEQLERFMEVYNELDENRPKVETIQAQGQEYIKRQNQMKVSSSNLQ 7719

Human  6515 QSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTV 6579
            .::..|:|:|..|.|:..::|.|||.||..||||.::||.|:.|||.||:.|:.|.|.|.:|.|:
  Fly  7720 HTLRTLKQRWDAVVSRASDKKIKLEIALKEATEFHDTLQAFVEWLTQAEKLLSNAEPVSRVLETI 7784

Human  6580 LSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERG 6644
            .:|:|||||...:|:.||:.::.||:.|..||:.||||||:||||||||||.|||:||.::.||.
  Fly  7785 QAQMEEHKVLQKDVSTHREAMLLLDKKGTHLKYFSQKQDVILIKNLLVSVQHRWERVVSKAAERT 7849

Human  6645 RSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELE---ISNDPDKIKLQLSKHKEFQKTLGGKQ 6706
            |:||...|.|::|::||..::.:|::.|..||..:|   .|.:|.|||..:.|.||..:.||.||
  Fly  7850 RALDHGYKEAREFNDAWSGMMQYLQETEQVLDQIIEEATASKEPQKIKKYIGKLKETHRQLGAKQ 7914

Human  6707 PVYDTTIRTGRALKEKTLLPE-DSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDA 6770
            .|||.|:|||:.|.|:.  |: |...||..|.|::::|..|..||::||.|||||||.||||.||
  Fly  7915 SVYDGTMRTGKNLLERA--PKGDRPVLDKMLIELKEQWTRVWSKSIDRQRKLEEALLLSGQFSDA 7977

Human  6771 LQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRD 6835
            |..|:|||.|.:.:|.|:.||||||:.|..|.:.||..:::|.||...:|.:.::||:| |.|.:
  Fly  7978 LGELLDWLKKAKSRLNENGPVHGDLETVQGLCEHHKHIEQDLQKRAAQMQGVLKTGRDL-ERSGN 8041

Human  6836 DTTWVKGQLQELSTRWDTVCKLSVSKQ-SRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGAL 6899
            :.. |..||.|:.:.|:.| |.:|:|: .||:.||..||.....|..|.:||..||..||:....
  Fly  8042 NPE-VGRQLDEMQSIWEEV-KSAVAKRGERLQVALVDAEKLNARVQALFDWLDHAEHKLRYAKNA 8104

Human  6900 PDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVL 6964
            |||.:..:.::|.|.:|||.:..:..:........|.|:...:||.|..||:|::||:.|:|||.
  Fly  8105 PDDEKVSREMMDIHMDFMKDLRVREREKTETFEYAEDIINKAYPDAIPIIKNWLSIIQQRWEEVR 8169

Human  6965 TWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFME 7029
            .||...:.:||..|..|....:.:||||||:...|.||:....|.:|..|..|:.||.:|:.|||
  Fly  8170 QWAINRESKLEQHLQSLKDLDDTIEELLAWLSGLEGTLLNLKHEQLPDEIPPVEKLIEDHKEFME 8234

Human  7030 EMTRKQPDVDRVTKTYK-----RKNIEPTHAPFIEKS-------RSGGRKSLSQPTP-------- 7074
            ...|:|.:|||..|..:     ||.......|..:.|       |.|.|.:.::.||        
  Fly  8235 NTARRQNEVDRACKPRQLPPGARKPSRSGKTPVFKGSRDQGLNARKGSRITPTRDTPDRDRLPHY 8299

Human  7075 ----PPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKK 7135
                .|.....:.|.::||...|..:|:.||:|:.||||.|||.|..|::::...||.:|.|||:
  Fly  8300 GPRFSPSTSGPELEFRSPRAKLLWTKWRDVWMLSWERQRLLNDHLLYLKDVERARNFSWDDWRKR 8364

Human  7136 YMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDY 7200
            ::::|||||||:.|.||::|||.:|.|.|..||||||.:||.|:.|||.||||:|||:|:|.||:
  Fly  8365 FLKYMNHKKSRLTDLFRKMDKDNNGMIPRDVFIDGILNTKFDTSGLEMKAVADLFDRNGEGLIDW 8429

Human  7201 YEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFFLGNQFGDSQQLR 7265
            .||:|||.|:....:|..|:|||.|||.|.|..|.|.::|:|.|:||.|||      |||||:||
  Fly  8430 QEFIAALRPDWQERKPANDSDKIHDEVKRLVMLCTCRQKFRVFQVGEGKYR------FGDSQKLR 8488

Human  7266 LVRILRSTVMVRVGGGWMALDEFLVKNDPCRVHHPGSKIKRSDSSSSISSQSPIARGRTNIELRE 7330
            |||||||||||||||||:||||||.||||||                       |:|||||||||
  Fly  8489 LVRILRSTVMVRVGGGWVALDEFLQKNDPCR-----------------------AKGRTNIELRE 8530

Human  7331 KFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPSSPATPASGTKTSLQF 7395
            :|||.:|.||.|..|..  |||.|::.|.    :|||....|...:::|                
  Fly  8531 QFILADGVSQSMAAFTP--RRSTPNAAAT----ASSSPHAHNGGSSNLP---------------- 8573

Human  7396 SRCYDKPWLVNSKAGTPIRDSHSPDLQLPTPEVIPSSGSKLKRPTPTFHSSRTSLAGDT--SNSS 7458
                            |......|.:::....|         |..|....||:||:..|  |.|.
  Fly  8574 ----------------PYMSGQGPIIKVRERSV---------RSIPMSRPSRSSLSASTPDSLSD 8613

Human  7459 SPASTGAKTNRADPKK----------------SASRPGSRAGSRAGSRASSRRGSDASDFDLLET 7507
            :..|.|..:.|..|:|                :.|:|.||..||.||:..||.||..|       
  Fly  8614 NEGSHGGPSGRYTPRKVTYTSTRTGLTPGGSRAGSKPNSRPLSRQGSKPPSRHGSTLS------- 8671

Human  7508 QSACSDTSESSAAGGQGNSRRGLNKPSKIPTMSKKT-TTASPRTPGPKR 7555
                .|:::.             :.||:||.....| :|||..||.|.|
  Fly  8672 ----LDSTDD-------------HTPSRIPQRKPSTGSTASGTTPRPAR 8703

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MACF1NP_001380991.1 SAC6 36..>292 CDD:227401 60/116 (52%)
SPEC 581..675 CDD:197544 26/95 (27%)
SPEC 677..866 CDD:238103 67/189 (35%)
SPEC 1159..1338 CDD:413338 36/180 (20%)
PLEC 1764..1800 CDD:197605 15/43 (35%)
PLEC 1807..1838 CDD:197605 8/46 (17%)
PLEC 2285..2317 CDD:197605 9/31 (29%)
PLEC 2681..2718 CDD:197605 10/88 (11%)
SbcC <3364..3905 CDD:223496 151/957 (16%)
SPEC 3486..3722 CDD:238103 68/433 (16%)
SPEC 3878..4106 CDD:238103 62/252 (25%)
Smc 4187..5025 CDD:224117 190/901 (21%)
SMC_prok_B 4877..5807 CDD:274008 261/940 (28%)
SPEC 5343..5556 CDD:238103 81/212 (38%)
SPEC 5778..5990 CDD:238103 60/213 (28%)
SPEC 5888..6104 CDD:238103 70/216 (32%)
SPEC 6106..6323 CDD:238103 77/216 (36%)
SPEC 6326..6542 CDD:238103 87/217 (40%)
SPEC 6547..6761 CDD:238103 103/217 (47%)
SPEC 6766..6978 CDD:238103 80/212 (38%)
SPEC 6988..7112 CDD:197544 47/147 (32%)
EFh 7146..7208 CDD:238008 37/61 (61%)
GAS2 7221..7296 CDD:128539 52/74 (70%)
PHA03307 7379..>7553 CDD:223039 42/192 (22%)
shotNP_725339.1 SAC6 204..>420 CDD:227401 87/211 (41%)
CH 223..327 CDD:306753 55/103 (53%)
SPEC 471..689 CDD:238103 57/243 (23%)
SPEC 690..866 CDD:238103 63/176 (36%)
SH3 885..922 CDD:327375 13/36 (36%)
SPEC 1047..1250 CDD:238103 46/229 (20%)
SPEC 1153..1390 CDD:238103 49/252 (19%)
PLEC <1498..1526 CDD:197605 9/27 (33%)
Plectin 1949..1981 CDD:307019 10/32 (31%)
DNA_pol3_delta2 <2711..3178 CDD:331068 71/482 (15%)
DUF4775 3026..3357 CDD:330579 55/334 (16%)
SMC_N <4904..5566 CDD:330553 136/678 (20%)
SPEC 5304..5513 CDD:238103 40/215 (19%)
SPEC <5658..5787 CDD:321951 23/132 (17%)
SPEC 5793..6007 CDD:238103 59/240 (25%)
SPEC 6011..6220 CDD:238103 48/217 (22%)
SPEC 6118..6330 CDD:238103 48/211 (23%)
PRK09039 <6279..6441 CDD:332967 34/161 (21%)
SPEC 6443..6660 CDD:238103 86/217 (40%)
SPEC 6663..6878 CDD:238103 60/219 (27%)
SPEC 6880..7087 CDD:238103 49/219 (22%)
SPEC 6986..7196 CDD:238103 60/209 (29%)
SPEC 7196..7417 CDD:238103 75/221 (34%)
SPEC 7314..7526 CDD:238103 75/212 (35%)
SPEC 7528..7747 CDD:238103 87/218 (40%)
SPEC 7749..7968 CDD:238103 105/220 (48%)
SPEC 7973..8181 CDD:238103 79/210 (38%)
EF-hand_7 8373..8437 CDD:316058 39/63 (62%)
GAS2 8450..8522 CDD:128539 55/100 (55%)
Herpes_ICP4_C 8550..>8795 CDD:332854 51/223 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 153 1.000 Domainoid score I4281
eggNOG 1 0.900 - - E2759_KOG0516
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 2383 1.000 Inparanoid score I34
Isobase 1 0.950 - 0 Normalized mean entropy S7584
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D17559at33208
OrthoFinder 1 1.000 - - FOG0003564
OrthoInspector 1 1.000 - - otm40714
orthoMCL 1 0.900 - - OOG6_101076
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R9918
SonicParanoid 1 1.000 - - X2438
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1211.750

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