Protein Alignment HEY2 and Sidpn

DIOPT Version :10

• Sequence 1: NP_036391.1
• Gene: HEY2 / 23493
• HGNCID: 4881
• Length: 337
• Species: Homo sapiens
• Sequence 2: NP_523599.1
• Gene: Sidpn / 35168
• FlyBaseID: FBgn0032741
• Length: 507
• Species: Drosophila melanogaster
• Alignment Length: 459
• Identity: 107/459 - (23%)
• Similarity: 170/459 - (37%)
• Gaps: 175/459 - (38%)

Human    21 GSENNYSGQSTSSVIRLNSPTTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGS- 84
            ||.|. ||..:..::......|:||.::::..:.::|||||.|||.||:.|:.|:..:.:.|.:
  Fly    24 GSTNG-SGIKSIGLVSSTQNVTSSQDISKRTNKPLMEKRRRARINQSLAILKALILESTKTQNAK 87

Human    85 --------AKLEKAEILQMTVDHLKMLQATGGKGYFDAHALAMDFMSI-----GFRECLTEVARY 136
                    .|||||:||::||.|            |..|. .:|..::     |:.:|..|||||
  Fly    88 NGEGQAKHTKLEKADILELTVRH------------FQRHR-NLDDPTVNKYRAGYTDCAREVARY 139

Human   137 LSSVEGLDSSDPL-----------RVRLVSHLSTC-------------ATQREAAAMTSSMAHHH 177
            |::.|    ..|:           :.||:.||..|             |...|:.:.:|....:|
  Fly   140 LATPE----PPPMGTMPTLAEPGSKARLLRHLDQCIAEIDVEICPHSTAAFAESPSSSSCFDLNH 200

Human   178 --------HPL-------HPHHWAAAFHHL----------PAALLQPN--GLHASESTPCRLSTT 215
                    |.|       :|..::.....:          ||...:.|  ||.|...||..:...
  Fly   201 GKKSQPEEHSLDYSSQDSNPVDYSKGLKMVAAEQRTLPVTPAPQDENNNRGLQAQAQTPIPIQVQ 265

Human   216 SE-----------VPP----------------------------------AHGSALLTATFAHAD 235
            |:           |.|                                  |:|..:|...:....
  Fly   266 SQTQGQTSPHVDAVAPSELSYEEDRNKVCANVLEQYKQQLKAHVQQQPESANGVLVLPPHYVQLA 330

Human   236 SALRMPSTGSVAPCVPPLST-----SLLSL--------------------SATVHAAAA------ 269
            :||.:    |..|.|.|::|     .|:.|                    :|.|.||||
  Fly   331 AALGL----SAQPLVDPIATRTDFERLIELQRVQPHLAGKLSPSFPGGLEAAHVAAAAAAYANSM 391

Human   270 --AATAAAHSFPLSFAGA-FPML----PPNAAAAVAAATAISPPLSVSAT--SSPQQTS---SGT 322
              ||:|.|....::.:|| .|.:    |.:.||:|::..::|...|:.||  |||:..|   |..
  Fly   392 AVAASAGASVAAMATSGAGTPTVHQERPASVAASVSSGVSMSELKSMPATQQSSPRSESGIGSNE 456

Human   323 NNKP 326
            |..|
  Fly   457 NEAP 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HEY2	NP_036391.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52		8/30 (27%)
		bHLH-O_HEY2	40..121	CDD:381490	28/89 (31%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250	47..116		24/77 (31%)
		ORANGE	119..165	CDD:128787	17/74 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	307..337		10/25 (40%)
		YRPW motif	327..330		107/459 (23%)
Sidpn	NP_523599.1	bHLH_O_HES	58..116	CDD:381416	25/70 (36%)
		Hairy_orange	124..172	CDD:462193	15/51 (29%)