Protein Alignment CES3 and Nlg3

DIOPT Version :9

• Sequence 1: NP_079198.2
• Gene: CES3 / 23491
• HGNCID: 1865
• Length: 571
• Species: Homo sapiens
• Sequence 2: NP_001036685.2
• Gene: Nlg3 / 40912
• FlyBaseID: FBgn0083963
• Length: 1159
• Species: Drosophila melanogaster
• Alignment Length: 665
• Identity: 176/665 - (26%)
• Similarity: 275/665 - (41%)
• Gaps: 174/665 - (26%)

Human    36 VDTTLGRVRGRQVGVKGTD-RLVNVFLGIPFAQPPLGPDRFSAPHPAQPWEGVRDASTAPPMCLQ 99
            ::|..|.:.|..|.:.|.. ..|..:.|||:|.||:|..||..|..|..|.||:.|....|:|.|
  Fly   158 INTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPVCPQ 222

Human   100 DVESMNSSRFVL----NGKQQ--------IFSVSEDCLVLNVYSPAEV----------------- 135
            .:..:::....|    .|:.:        :.:.|||||.||:|.|.:|
  Fly   223 RLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSSSSSSAGSS 287

Human   136 -------------------PAGSGR----PVMVWVHGGALITGAATSYDGSALAAYGDVVVVTVQ 177
                               .||||.    ||:|:|||.:....:...||||.||:||.::|||:.
  Fly   288 SSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVLASYGQILVVTIN 352

Human   178 YRLGVLGFFSTGDEH---APGNQGFLDVVAALRWVQENIAPFGGDLNCVTVFGGSAGGSIISGLV 239
            ||||||||.:...:.   .|.|.|.:|::|||.|::||||.||||.|.:|:.|...|.:.:..|:
  Fly   353 YRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGAACVHFLI 417

Human   240 LS-PVAAG-LFHRAITQSGVITTPGIIDSHPWPLAQKIANTLACSSSSP-AEMVQCLQQKEGEEL 301
            .| .|..| ||:|||..||....|..:.|:|...|..:|:.:.|:|..| |.:::||::|..::|
  Fly   418 SSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCASDLPHAHLMKCLREKTLDQL 482

Human   302 VLSKKLK----NTIYPLTVDGTVF---------PKSPKELLKEKPFHSVPFLMGVNNHEFSWLIP 353
             ||..::    ...:..::||.|.         |.||....:.:...:....:|   .|......
  Fly   483 -LSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAAGNGLG---GEAGIAAA 543

Human   354 RGWGLLDTME-----------QMSREDMLAISTPV-----LTSLDVP------------------ 384
            .|||....:|           ::||.|::|..|..     ..|.||.
  Fly   544 GGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAFFSFNSGDVQYGIEADRRSRILKAYVRN 608

Human   385 ------PEMMPTVIDEY-----------------LGSNSDAQAKCQAFQEFMGDVFINVPTVSFS 426
                  .|:..|:::||                 |.:.||||....|.|           ||..
  Fly   609 TYTFHLNEIFATIVNEYTDWERPVQHPINIRDETLEALSDAQVVAPAAQ-----------TVDL- 661

Human   427 RYLRD-SGSPVFFYEFQHRPSSFAKIKPAWVKADHGAEGAFVFGGPFL--MDESSRLAFPEATEE 488
             :..| ..|.::.:::|.|...:    |......||.:..::||.|.:  .:..:|    ..|:.
  Fly   662 -HSADHRNSYLYVFDYQTRFGDY----PQRQGCIHGEDLPYIFGAPLVGGFNHFTR----NYTKT 717

Human   489 EKQLSLTMMAQWTHFARTGDPNS---------------KALPPWPQFNQA-EQYLEINPVPRAGQ 537
            |..||..:|..|::|.|||:||.               |.: .|..:... ::||..:..|:...
  Fly   718 EISLSEVVMFYWSNFVRTGNPNEQMETEHGSRQERSRYKTI-EWTAYESVHKKYLNFDTKPKLKN 781

Human   538 KFREAWMQFWSETLP 552
            .:|...:.||...:|
  Fly   782 HYRAHRLSFWLNLIP 796

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CES3	NP_079198.2	COesterase	32..547	CDD:278561	173/658 (26%)
		Aes	<129..>247	CDD:223730	56/162 (35%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	173/658 (26%)
		Aes	<313..>410	CDD:223730	44/96 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810