Protein Alignment CES3 and alpha-Est2

DIOPT Version :9

• Sequence 1: NP_079198.2
• Gene: CES3 / 23491
• HGNCID: 1865
• Length: 571
• Species: Homo sapiens
• Sequence 2: NP_001262345.1
• Gene: alpha-Est2 / 40908
• FlyBaseID: FBgn0015570
• Length: 566
• Species: Drosophila melanogaster
• Alignment Length: 568
• Identity: 170/568 - (29%)
• Similarity: 245/568 - (43%)
• Gaps: 127/568 - (22%)

Human    26 ATGPEVAQPEVDTTLGRVRGRQVGVKGTDRLVNVFLGIPFAQPPLGPDRFSAPHPAQPWEGVRDA 90
            :||..|.   :||..|:|||.|............|.|||:|:||:|..||.||.|.:||:||.:.
  Fly    28 STGHTVI---LDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNC 89

Human    91 ST--APPMCLQDVESMNSSRFVLNGKQQIFSVSEDCLVLNVYSPA---EVPAGSGRPVMVWVHGG 150
            :|  :.||          .|.:|.|   |...|||||.||||..|   |.|.    ||:||::||
  Fly    90 TTNRSKPM----------QRNMLLG---IVEGSEDCLHLNVYVKALKSEKPL----PVIVWIYGG 137

Human   151 ALITGAATSYDGSALAAYG-------DVVVVTVQYRLGVLGFFSTGDE--HAPGNQGFLDVVAAL 206
            ....|.| |.|     .|.       .||.|.:.|||..|||.|..|.  ..|||.|..|.|.||
  Fly   138 GFQKGEA-SRD-----IYSPDYFMKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMAL 196

Human   207 RWVQENIAPFGGDLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGV-----ITTPGIIDS 266
            ||:.:|||.|.||.|.:|:.|.|||.:.:..::.:....||||:||.|||.     :.:|    .
  Fly   197 RWISQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESP----D 257

Human   267 HPWP--LAQ--------KIANTLACSSSSPAEMVQCLQQKEGEELVLSKKLKN--------TIYP 313
            :.|.  |||        |.|:.|:..|...|..:..:.|    :::...::::        .|.|
  Fly   258 NNWAFRLAQNLGYKGDEKDADVLSFLSKVCARQIAAIDQ----DVINLDEVRSFLLFAFGPVIEP 318

Human   314 LTVDGTVFPKSPKELLKEKPFHSVPFLMGVNNHE--FSWLIPR--GWGLLDTMEQMSREDMLAIS 374
            ...|..|.||..|:||.|...:.:|.::|.|:.|  ||:.:.|  .|.|.:....:.||   ...
  Fly   319 YETDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFEGLFSYQLVRKDPWALKNFHNILPRE---VRE 380

Human   375 TPVLTSLDVPPEMMPTVIDEYLGSNSDAQAKCQAFQEFMGDVFINVPTVSFS---------RYL- 429
            |..|...|:....:     :.|..|::.|...:.|:.      :|:    ||         |::
  Fly   381 TSSLEGQDLLVRRL-----KQLYFNNEMQESMEMFEA------LNI----FSHRQIWHDTHRFIL 430

Human   430 -RDS---GSPVFFYEFQHRPSSFAKIKPAWVKAD------HGAEGAFVFGGPFL--MDESSRLAF 482
             |.|   .:|.:.|.|......|.:.: ..|..|      |..|.:::|.....  :|:||.
  Fly   431 ARQSYAPKTPTYLYRFDFDSPHFNQFR-RLVCGDRIRGVAHADELSYLFYNIIASKLDKSSM--- 491

Human   483 PEATEEEKQLSLTMMAQWTHFARTGDPNSKAL--PPWPQFNQAEQYLE 528
                 |.|.:. .|:..||.||.:|:||...|  ..|......|..:|
  Fly   492 -----EYKTIE-RMVGMWTSFASSGNPNCPELGSAKWEAVQLKENAVE 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CES3	NP_079198.2	COesterase	32..547	CDD:278561	167/562 (30%)
		Aes	<129..>247	CDD:223730	49/129 (38%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	165/552 (30%)
		Aes	<117..>221	CDD:223730	47/113 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142623
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.790