DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BRD4 and tbrd-2

DIOPT Version :9

Sequence 1:	NP_001366220.1	Gene:	BRD4 / 23476	HGNCID:	13575	Length:	1362	Species:	Homo sapiens
Sequence 2:	NP_611401.2	Gene:	tbrd-2 / 37207	FlyBaseID:	FBgn0034423	Length:	674	Species:	Drosophila melanogaster

Alignment Length:	788	Identity:	156/788 - (19%)
Similarity:	272/788 - (34%)	Gaps:	219/788 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    31 AQAQPQPANAASTNPPPPE-TSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNL 94
            |..:|........|...|| ..:|....|.||:|.|..:.:|....|.::|..|.:|||...|.:
  Fly     2 ASCKPLSVKLKLPNRVQPEFIPHPGMAGRYTNKLHYFKKHLLDEARKKKYALDFLEPVDTEALMV 66

Human    95 PDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQ 159
            |.||.:|..|||:|||.||::||||.:..|.|.||..:.:||:::|:.||.:....:.|||.|.:
  Fly    67 PTYYTVIHRPMDIGTIVKRVQNNYYKSVNEAIADFKQIISNCFLFNRSGDVVYRKGQMLEKFFHK 131

Human   160 KINELPTEETEIMIVQAKGRGRGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHP 224
            |:..:|:.                             |.......|.....|:.|.|....|...
  Fly   132 KLRGMPSG-----------------------------PEVPCNRDPKAVGRPRTNAPSSAQTERK 167

Human   225 FPAVTPDL---IVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKK 286
            ...:...|   ..||..||                                       :...:.|
  Fly   168 CRELLKKLQSITNQTDAMT---------------------------------------RNFFSNK 193

Human   287 --GVKRKADTTTPTTIDPI-----------HEPPSLPPEPKTTKLGQRRESSRPVK--------- 329
              .:::|.|.....:::..           |||         .|:...|..::|..
  Fly   194 WDSLQKKVDRQYFKSVNEFCLHVDGCFRKYHEP---------AKILYERVFNQPAAWCTSMNGNS 249

Human   330 --PPKKDVPDSQQHPAPEKSSKVSEQLKCC----SGILKEMFAKKHAAYAWPFYKPVDVEALGLH 388
              ....:..|..:..|..|.: |:..::|.    ||                  :|:..::| :.
  Fly   250 SLESALNAADLNELLAAAKLT-VNSLMQCVQMPGSG------------------EPLTAKSL-VE 294

Human   389 DYCDII------------KHPMDMSTIKSKLEAREYRD--AQEFGADVRLMFSN------CYKYN 433
            .:||.:            ..|...|:.:.|:...:..|  ..||...:.|:..|      .....
  Fly   295 TFCDTLNKMINKMEAGQRNSPNPSSSKRQKMSPEQETDLVQGEFKPAMELLSGNEIDNLMAVSIE 359

Human   434 PPDHEVVAMARKLQD----VFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSS 494
            ..|.|.:..:.::.|    ..:..|||:|....:.::.:...         ....||::..|.|.
  Fly   360 SSDDEAIDASMRITDADRCATQKLFAKLPTNAMKEIIHMVQQ---------IEGFSSENCGDLSF 415

Human   495 DSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVE- 558
            |......|:           ...:|      :|:::..:...|.|.||.:..:||..:|..:.:
  Fly   416 DVKGLATDT-----------MIMMK------SAVTKATRAHSKLKLKDMQPSEKEGLQRALQSQL 463

Human   559 ------ENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTY------------------ 599
                  .||..:...|......|||::|:.|.|:..||:.:|..|..
  Fly   464 VNITRMLNKNRRRCGPLINFRNKNNTANNVVRKRATAPLTAKLKPLQANVMAPQLGAGVVETHNL 528

Human   600 -ESEEEDKCKPMSYE-----EKRQLSLDINKL---PGEKLGRVVHIIQSREPSLKNSNPDEIEID 655
             ::.::|...|:...     ..|.|.::.|.|   |.....::.|::: .:.|..:|:..|::..
  Fly   529 SDTSDDDVSAPVKLSAIGGTPMRNLPINSNPLQMQPIRSPPKLPHVVE-LQMSSSSSSESEMKSK 592

Human   656 FETLKPSTLRELE----RYVTSCLRKKRKPQAEKVDVIAGSSK-MKGFSSSESESSSESSSSDSE 715
            ...|..|..|.:.    |..::.....|...:......||||. .:..|||.|.|||.:||..::
  Fly   593 SGRLSRSRSRSMSDTKLRPRSNSSASSRSNSSSSSGSNAGSSSGSRSRSSSSSSSSSNNSSESND 657

Human   716 DSETEMAP 723
            .|:.|:.|
  Fly   658 SSDVEVVP 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BRD4	NP_001366220.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		6/27 (22%)
		Bromo_Brdt_I_like	58..164	CDD:99929	43/105 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..229		6/54 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..352		13/133 (10%)
		Bromo_Brdt_II_like	353..454	CDD:99930	18/128 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	463..615		30/182 (16%)
		NPS region	484..503		5/18 (28%)
		BID region	524..579		14/61 (23%)
		BET	609..673	CDD:407211	14/75 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	674..1100		17/51 (33%)
		PRK03427	<809..>922	CDD:235124
		C-terminal (CTD) region	1047..1362
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1116..1339
		BRD4_CDT	1319..1362	CDD:407248
tbrd-2	NP_611401.2	Bromo_gcn5_like	34..136	CDD:99941	40/101 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.860