DRSC/TRiP Functional Genomics Resources

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Protein Alignment BRD4 and tbrd-3

DIOPT Version :9

Sequence 1:NP_001366220.1 Gene:BRD4 / 23476 HGNCID:13575 Length:1362 Species:Homo sapiens
Sequence 2:NP_726307.1 Gene:tbrd-3 / 246604 FlyBaseID:FBgn0050417 Length:268 Species:Drosophila melanogaster


Alignment Length:332 Identity:94/332 - (28%)
Similarity:140/332 - (42%) Gaps:83/332 - (25%)


- Green bases have known domain annotations that are detailed below.


Human   343 APEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKL 407
            |.:::.:.|.::..|..|:|.:|:..:...||.||:|:|.:.||||||.:|::.|||:||::.:|
  Fly     3 AKQETERSSPEINACKVIIKRLFSSTYKNIAWVFYEPLDPQLLGLHDYHEIVREPMDLSTVRHRL 67

Human   408 EAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPA 472
            ....|..|.:|..|:||:|.|.|.|..|||....||::||.:||..::::      .:...||  
  Fly    68 NTGCYLSAADFAKDIRLIFYNTYLYTNPDHLCYHMAKQLQIIFEEMYSQV------QLYICSS-- 124

Human   473 VPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPK 537
               .:||.|...||...|||||..|                                        
  Fly   125 ---GSKVRAEEESSSDESDSSSPED---------------------------------------- 146

Human   538 KKEKDKKEKKKEKHKRKEEVEENKKSKA-KEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYES 601
                              ||..::.|.: ...||..|.....:        |.| ...||.|.|:
  Fly   147 ------------------EVNGSEVSPSIMGAPPSCTPTTECT--------PTP-DWTPPATLET 184

Human   602 EEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRE 666
            .|:.  :|.:.||...|...|.:|.||.|..|:|.||..| ..:..| .|:|.|...||..|.|.
  Fly   185 SEQQ--EPFTTEEDLDLHAKIQQLDGEVLLHVIHFIQRME-GAEYCN-KELEFDICKLKVHTKRG 245

Human   667 LERYVTS 673
            :..|:.|
  Fly   246 IRDYLAS 252

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BRD4NP_001366220.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..58
Bromo_Brdt_I_like 58..164 CDD:99929
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 174..229
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 242..352 1/8 (13%)
Bromo_Brdt_II_like 353..454 CDD:99930 42/100 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 463..615 28/152 (18%)
NPS region 484..503 8/18 (44%)
BID region 524..579 6/55 (11%)
BET 609..673 CDD:407211 23/63 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 674..1100 94/332 (28%)
PRK03427 <809..>922 CDD:235124
C-terminal (CTD) region 1047..1362
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1116..1339
BRD4_CDT 1319..1362 CDD:407248
tbrd-3NP_726307.1 Bromo_Brdt_II_like 13..114 CDD:99930 42/100 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000322
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR22880
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X197
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.910

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