DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PHF3 and BYE1

DIOPT Version :9

Sequence 1:	XP_011533950.1	Gene:	PHF3 / 23469	HGNCID:	8921	Length:	2048	Species:	Homo sapiens
Sequence 2:	NP_012921.3	Gene:	BYE1 / 853865	SGDID:	S000001488	Length:	594	Species:	Saccharomyces cerevisiae

Alignment Length:	705	Identity:	137/705 - (19%)
Similarity:	243/705 - (34%)	Gaps:	210/705 - (29%)

- Green bases have known domain annotations that are detailed below.

Human   652 VKEELEHPGVEHFKEEDKLKLKKPEKNLQPRQRRSSKSFSLDEPPLFIPDNIATIRREGSDHSSS 716
            ::||.|.|           |.|:.:|.:.....::.||.|..||    ..:...:|.:..|.:..
Yeast    21 LQEETEAP-----------KKKRTKKKVDSAIEKNKKSDSSQEP----RKDTENVRTDEVDEADE 70

Human   717 FESKYMWTPSKQCG-------FCKKPHGNRFMVGCGRCDDWFHGDCVGLSLSQAQQMGEEDKEYV 774
            ...:.:      ||       ..:..||:  ||.|..||.|.|..|:.........:..||.:|.
Yeast    71 GYVRCL------CGANNENYDAAEYSHGD--MVQCDGCDTWQHIKCMTDGKDTIDGLMSEDSKYY 127

Human   775 CVKCCAEEDKKTEILDPDT---LENQATVEFHSGDKTMECEKLGLSKHTTNDRTKYIDDTVKHKV 836
            |           |:.||..   ||.....|....:...:.....::.|..||...::|:....|
Yeast   128 C-----------ELCDPSLYAHLETSKEAEVSEDEDYHDDVYKPVNDHDDNDADVFLDEESPRK- 180

Human   837 KILKRESGEGRNSSDCRDNEIKKWQLAPLRKMGQPVLPRRSSEEKSEKIPKESTTVTCTGEKASK 901
               ::.|.:.......:..::||               ...|:::::.|            .|:|
Yeast   181 ---RKRSPDSAKGIHIKSKQVKK---------------SNGSKKRNKSI------------DAAK 215

Human   902 PGTHEKQEMKKKKVEKGVLNVHPAASASKPSADQIRQSVRHSLKDILMKRLTDSNL-----KVPE 961
            ..|.|.:...:|..|             .....::|.:.......:..|.:....:     ::|:
Yeast   216 SDTAENEMPTRKDFE-------------SEKEHKLRYNAEKMFSTLFSKFIVPETIEAKLYELPD 267

Human   962 EK-----AAKVATKIEKELFSF-----FRDTDAKYKNKYRSLMFNLKDPKNNILFKKVLKGEVTP 1016
            .|     :.:.|..:|:||:..     |...|..|..|.|||..||||.||..|...|::|::..
Yeast   268 GKDVISISQEFAHNLEEELYKACLNVEFGTLDKIYTEKVRSLYSNLKDKKNLELKAHVVEGKLPL 332

Human  1017 DHLIRMSPEELASKELAAWRRRENRHTIEMIEKEQREVERRPITKITHKGEIEIESDAPMKEQEA 1081
            :.|:.|:..|||:.:|..:  :|.|..| ::|....||..:|:...||||:..||
Yeast   333 NKLVNMNASELANPDLQEF--KEKRDKI-ILENFIVEVPDKPMYVKTHKGDELIE---------- 384

Human  1082 AMEIQEPAANKSLEKPEGSEKQKEEVDSMSKDTTSQHRQHLFDLNCKICIGRMAPPVDDLSPKKV 1146
              :|.||               :|:: ..|||:...|.                  :|.:...|.
Yeast   385 --DIAEP---------------QEDI-LYSKDSIRLHN------------------IDSIDSDKS 413

Human  1147 KVVVGVARKHSDNEAESIADALSSTSNILASEFFEEEKQESPKSTFSPAPRPEMPGTVEVESTFL 1211
            |:          .:..:|:...|.::.|         .:||....|.      .||   :...|.
Yeast   414 KI----------EQTHAISKEPSPSTII---------NEESLNCAFL------YPG---LGLEFT 450

Human  1212 ARLNFIWKGFINMPSVAKFVTKAYPVSGSPEYLTEDL------PDSIQVGGRISPQTVWDYVEKI 1270
            ..||:|                     |:.:.|..|:      ...:.|.||:...|...|:::|
Yeast   451 GYLNYI---------------------GASQKLRRDIFKEAIGDGKLYVEGRLPTTTAAPYLKEI 494

Human  1271 KASGTKEICVVRFTPVTE-EDQISYTLLFAYFSSRKRYGVAANNMKQVKDMYLIP 1324
            ..|  :.|.|.:..|..: |.:.::..:.....::.|........:..||.|::|
Yeast   495 SCS--RAILVYQLFPSNDSESKTTFADVVDSLENKGRIAGIKPKTRYEKDFYIVP 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PHF3	XP_011533950.1	PHD_PHF3	728..778	CDD:277108	16/56 (29%)
		TFIIS_M	934..1044	CDD:284835	32/124 (26%)
		SPOC	1218..1324	CDD:285043	18/112 (16%)
		PRP38_assoc	<1941..2035	CDD:289628
		DUF1777	1954..>2048	CDD:285811
BYE1	NP_012921.3	PHD_Bye1p_SIZ1_like	74..131	CDD:277045	17/75 (23%)
		TFS2M	235..354	CDD:128786	30/120 (25%)
		SPOC	434..589	CDD:400205	28/146 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I3141
eggNOG	1	0.900	-	-		E1_KOG1634
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6592
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11477
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950