DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PHF3 and phf3

DIOPT Version :9

Sequence 1:	XP_011533950.1	Gene:	PHF3 / 23469	HGNCID:	8921	Length:	2048	Species:	Homo sapiens
Sequence 2:	XP_005157087.1	Gene:	phf3 / 553518	ZFINID:	ZDB-GENE-090313-207	Length:	1691	Species:	Danio rerio

Alignment Length:	2122	Identity:	691/2122 - (32%)
Similarity:	960/2122 - (45%)	Gaps:	518/2122 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    10 MDIV-DTFNHLIPTEHLDDALFLGSNLENEVCEDFSASQNVLEDSLKNMLSDKDPMLGSASNQFC 73
            |||| .:||||:|::.|||:|.||.|||.|..::|.|..   ||||||||||||||.||||.||.
Zfish     1 MDIVGGSFNHLVPSDQLDDSLLLGQNLECEASDEFEAKP---EDSLKNMLSDKDPMFGSASTQFH 62

Human    74 LPVLDSNDPNFQMPCSTVVGLDDIMDEGVVKESGNDTIDEEELILPNR------NLRDKVEENSV 132
            |  |::.|  |::..|  ...|..|....|::|.:|....:...|.:|      ..|.......|
Zfish    63 L--LENED--FKLGSS--ADADHEMTGAGVRQSPSDGEHNQSGFLQDRRQAGQMQRRQTASRGRV 121

Human   133 RSPRKSPRLMAQEQVRSLRQSTIAKRSNAAPLSNTKKASGKTVSTAKAGVKQPERSQVKEEVCMS 197
            |..|..|...|.|...  |:||.::..:.   .|:.....:.:.:.:.||         .||..|
Zfish   122 RGRRLGPARKAAESYN--RESTCSEEHDR---DNSPDEKREALLSRRFGV---------HEVDSS 172

Human   198 LKPEYHKENRRCSRNSGQIEVVPEVSVSSSHSSVSSCLEMKDED--------GLDSKHKCNNPGE 254
            :.|.........:....:||::|..|.|....|.|:...:..:|        |||
Zfish   173 MNPVVVLRRLTVTVGGYKIELLPGPSQSFGSFSTSALQSLGFQDDGIIADGLGLD---------- 227

Human   255 IDVPSHELNCSLLSETCVTIGEKKNEALMECKAKPVGSPLFKFSDKEEHEQNDSISGKTGETVVE 319
                               :|:.::|.::: .:.|.............|:.............|:
Zfish   228 -------------------LGQNQDEQVVD-NSTPEAVGEVSIDQSTSHDVPMDFGPYVNPNEVQ 272

Human   320 E----MIATRKVE----QDSK------ETVKLSHEDDHILEDAGSSDISSDAACTNPNKTENSLV 370
            :    |:...|||    :|:|      :|.|||.:     :....:..::..|.....|.:.||.
Zfish   273 DTNSTMVLKPKVENATSEDAKKKNNQIKTQKLSAQ-----KPGNKNGTAARPAVKKLLKNKQSLS 332

Human   371 GLPSCVDEVTECNLELKDTMGIADKTENT--LERNKIEPLGYCEDAESNRQLESTEFNKSNLEVV 433
            ...:.....|:..|..|::....||..:|  .|.:|.:|:                  |..|: .
Zfish   333 AAKNKPSSPTKPGLLQKESKHPQDKKIHTGQPEVHKGKPI------------------KVGLK-R 378

Human   434 DTSTFGPESNILENAICDVPDQNSKQLNAIES-------TKIESHETANLQ--DDRNSQSSSVSY 489
            ..:..||:..   :.|..:.|.:|....|..|       ||..|.|:..|.  :.|...|.||..
Zfish   379 PGAALGPKDG---SKIQKIQDGHSASKTASPSGPLSPTITKKSSSESGPLSPTNSRKPSSDSVPL 440

Human   490 LESKSVKSKHTKPVIHSKQNMTTDAPKKIVAAKYEVIHSKTKVNVKSVKRNTDVPESQQNFHR-- 552
            ..:.|.|..::.|:                          :..|.:....|: ||.|..|..:
Zfish   441 SPTNSRKPSNSVPL--------------------------SSTNSRKPSSNS-VPLSPSNSRKPS 478

Human   553 -------PVKVRKKQIDKEPKIQSCNSGVKSVKNQAHSVLKKTLQDQTLVQIFKPL--THSLSDK 608
                   |...||...|..|.     |...|.|..:.||               ||  |:|....
Zfish   479 SNLVPLSPTNSRKLSSDSGPL-----SPTNSRKPSSDSV---------------PLSPTNSRRPS 523

Human   609 SHAHPG--CLKEPHHPAQTGHVSHSSQKQCHKPQQ-QAPAMKTNSHVKEELEHPGVEHFKEEDKL 670
            |.:.||  .::.||.|              .|||. .....|||..|...      :..:|:||:
Zfish   524 SESGPGVKSVQSPHPP--------------KKPQNPPTSGNKTNPPVANS------QGDEEQDKV 568

Human   671 KLKKPEKNLQPRQRRSSKSFSLDEPPLFIPDNIATIRREGSDHSSSFESKYMWTPSKQCGFCKKP 735
            |.||.||..|..:.|:|:|.|::||.||||||...:::| ::..:..||:.:|.|:|.|..||||
Zfish   569 KAKKIEKTQQRHKSRNSRSISIEEPQLFIPDNAPVVKKE-AEGDALAESETVWDPTKNCVLCKKP 632

Human   736 HGNRFMVGCGRCDDWFHGDCVGLSLSQAQQMGEEDKEYVCVKCCAEEDKKTEILDPDTLENQATV 800
            |.|||||||||||||||||||||.|::.|||.:||:||||:||||:||:||
Zfish   633 HNNRFMVGCGRCDDWFHGDCVGLDLAKVQQMEKEDQEYVCLKCCAQEDEKT-------------- 683

Human   801 EFHSGDKTMECEKLGLSKHTTNDRTKYIDDTVKHKVKILKRESGEGRNSSDCRDNEIKKWQLAPL 865
                     :..:|...|.....:.:.........::..::::||
Zfish   684 ---------QASELSDDKSAAKQKQRPQQSLTAGGIRPFRKDAGE-------------------- 719

Human   866 RKMGQPVLPRRSSEEKSEKIPKESTTVTCTGEKASKPGTHEKQEMKKKKVEKGVLNVHPAASASK 930
                     ||.||:.::|                  |.:.|.|.||.|:.        ..|:.|
Zfish   720 ---------RRPSEDSAQK------------------GPNVKHETKKVKIS--------PVSSKK 749

Human   931 PSADQIRQSVRHSLKDILMKRLTDSNLKVPEEKAAKVATKIEKELFSFFRDTDAKYKNKYRSLMF 995
            ||...||:|||.||::||:||..:|:||:..::.|:||.:.|||||:.|:..|:|||||||||.|
Zfish   750 PSTGHIRRSVRDSLEEILLKRSKESDLKISSDRPAEVARRTEKELFALFQGVDSKYKNKYRSLTF 814

Human   996 NLKDPKNNILFKKVLKGEVTPDHLIRMSPEELASKELAAWRRRENRHTIEMIEKEQREVERRPIT 1060
            ||||.|||:|||:||||||:|..|:||:.||||||||||||:|||||||||||||||||||||||
Zfish   815 NLKDAKNNVLFKRVLKGEVSPADLVRMTAEELASKELAAWRKRENRHTIEMIEKEQREVERRPIT 879

Human  1061 KITHKGEIEIESDAPMKEQEAAMEIQEPAANKSLEKPEGSEKQKE-EVDSMSK--DTTSQHRQHL 1122
            |||||||||||:..|.|..| |:|::.....|.:|.||  ||..| :|:|..|  |||:.|:.||
Zfish   880 KITHKGEIEIENQEPAKAPE-AIEVEPEPVLKVVEVPE--EKPPEIKVESPKKSIDTTNLHKSHL 941

Human  1123 FDLNCKICIGRMAPPVDDLSPKKVKVVVGVARKHSDNEAESIADALSSTSNILASEFFEEEKQES 1187
            ||||||||.||||||.::.|.|.|||...|.|:.|....||.....:.|| .|..:......:|.
Zfish   942 FDLNCKICTGRMAPPTEEASTKVVKVATTVVRRQSSATEESQPSTTTPTS-ALMDDLTLRAMEEG 1005

Human  1188 PKSTFSPAPRPEMPGTVEVESTFLARLNFIWKGFINMPSVAKFVTKAYPVSGSPEYLTEDLPDSI 1252
            ..:....:.|.:...:.|..:|||:.|..:|.|:::||:||:|:||:|.|||:.::||:||||:|
Zfish  1006 LLNFLPESSRADSLCSKEDTATFLSSLESLWGGYVDMPAVARFLTKSYLVSGTLDHLTQDLPDNI 1070

Human  1253 QVGGRISPQTVWDYVEKIKASGTKEICVVRFTPVTEEDQISYTLLFAYFSSRKRYGVAANNMKQV 1317
            |||||||||.||||||||:|||||||||:||:|.||||:||||||:||||||:||||.|||.|||
Zfish  1071 QVGGRISPQIVWDYVEKIRASGTKEICVIRFSPDTEEDEISYTLLYAYFSSRRRYGVVANNRKQV 1135

Human  1318 KDMYLIPLGATDKIPHPLVPFDGPGLELHRPNLLLGLIIRQKLKRQHSACASTSHIAETP----E 1378
            |||||||||:|:||||.:|||||||||.:||||||||||||:.||...... .|.::|.|    |
Zfish  1136 KDMYLIPLGSTEKIPHQIVPFDGPGLETNRPNLLLGLIIRQRPKRDFGVIL-PSDVSEAPSFLAE 1199

Human  1379 SAPPIALPPDKKSKIEVSTEEAPEEENDFFNSFTTVLHKQRNKPQQNLQEDLPTAVEPLMEVTKQ 1443
            |.|.:..|  :|:.:.:.||:          ||.:.|...|.|...:|.:.:  ..||::: |:.
Zfish  1200 SKPQVDYP--QKTPVALDTEQ----------SFISDLGNARKKDTTDLIKSV--VEEPILD-TET 1249

Human  1444 EPPKPLRFLPGVLIGWENQPTTLELANKPLPVDDILQSLLGTTGQVYDQAQSVMEQN-------T 1501
            :....||||||||               .||                ::|.|....|       |
Zfish  1250 DENVSLRFLPGVL---------------KLP----------------EKAASCSNDNMKSDSTKT 1283

Human  1502 VKEIPFLNEQTNSKIE--------KTDNVEVTDGENKEIKVKVDNISESTDKSAE-IETSVVGSS 1557
            ..:.|.::...|:.:.        :.|...:...|.|.:|.:...:|.|.:.|:| .||:||
Zfish  1284 EAKTPSVDSGNNATVSPKPIASAPRLDRFVIKKKEPKAVKTEQAPVSVSLEISSEKKETAVV--- 1345

Human  1558 SISAGSLTSLSLRGKPPDVSTEAFLTNLSIQSKQEETVESKEKTLKRQLQEDQENNLQDNQTSNS 1622
                     |||..||.|||||:||::|:....:||:......:...|         :.:||::|
Zfish  1346 ---------LSLSDKPADVSTESFLSSLTNTKPKEESESCSTASPTSQ---------ETSQTTSS 1392

Human  1623 SPCRSNVGKGNIDG--NVSCSENLVANTARSPQFINLKRDPRQAAGRSQPVTTSESKDGDSCRNG 1685
            ...:.:|.:|:...  |.:.| :..|.|..||..| |||      ..|.|..|.......|....
Zfish  1393 GTSKDSVDEGSSSAPKNETIS-SPTATTKVSPAGI-LKR------ASSAPEPTESKLPESSSEKP 1449

Human  1686 EKHMLPGLSHNKEHLTEQINVEEKLCSAEKNSCVQQSDNLKVAQNSPSVENIQTSQAEQAKPLQE 1750
            |:.:.|..|..:....|.|.....:.|..||..::||   :.:..:|.|.|         .|:..
Zfish  1450 EQKVTPQPSTQECKAIEDIQAITTISSIGKNEGLKQS---RSSSFNPKVYN---------PPVFH 1502

Human  1751 DILMQNIETVHPFRRGSAVATSHFEVGNTCPSEFPSKSITFTSRSTSPRTSTNFSPMRPQQPNLQ 1815
            ..|.                      |...|..:|           .|....:|.|::      .
Zfish  1503 SYLS----------------------GPPDPQFYP-----------PPANPAHFLPLQ------A 1528

Human  1816 HLKSSPPGFPFPGPPNFPPQSMFGFPPHLPPPLLPPPGFGFAQNPMVPWPPVVHLPGQPQRMMGP 1880
            ||   ||  ||..||..||..||   |...|.:|.||.........:|.||:.:....|..:  |
Zfish  1529 HL---PP--PFQFPPGPPPLQMF---PQSDPHMLAPPWPQTVPPQTLPPPPMAYESSLPTAL--P 1583

Human  1881 LSQASRYIGPQNFYQVKDIRRPERRHS---DPWGRQDQQQLDRPFNRGKGDRQRFYSDSHHLKRE 1942
            ||              ||.:..|:.:|   |...|:.::      ...|..|.|.:.|.||.|
Zfish  1584 LS--------------KDEKVSEKSYSDFVDKLSRRSEE------THRKDSRDREHYDKHHHK-- 1626

Human  1943 RHEKEWEQESERHRRRDRSQDKDRDRKSREEGHKDKERARLSHGDRGTDGKASRDSRNVDKKPDK 2007
                      .||..|||       .|.||..|..|||    |.
Zfish  1627 ----------SRHYERDR-------EKHRERSHSHKER----HS--------------------- 1649

Human  2008 PKSEDYEKDKEREKSKHREGEKDRDRYH-KDRDHTDRTKSKR 2048
             |.|.|||.:||..|.|   .:|||::. :|.||....|..|
Zfish  1650 -KDERYEKHRERRHSSH---HRDRDKHRSRDSDHEKHRKDSR 1687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PHF3	XP_011533950.1	PHD_PHF3	728..778	CDD:277108	37/49 (76%)
		TFIIS_M	934..1044	CDD:284835	71/109 (65%)
		SPOC	1218..1324	CDD:285043	80/105 (76%)
		PRP38_assoc	<1941..2035	CDD:289628	25/93 (27%)
		DUF1777	1954..>2048	CDD:285811	29/94 (31%)
phf3	XP_005157087.1	DUF4045	<341..732	CDD:330572	145/550 (26%)
		PHD_PHF3	625..675	CDD:277108	37/49 (76%)
		TFIIS_M	755..863	CDD:311443	71/107 (66%)
		SPOC	1027..1176	CDD:311609	112/148 (76%)
		Endomucin	1271..>1449	CDD:330316	51/206 (25%)
		RRM	1605..>1690	CDD:330708	37/137 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194324418
Domainoid	1	1.000	244	1.000	Domainoid score	I9970
eggNOG	1	0.900	-	-		E1_KOG1634
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	828	1.000	Inparanoid score	I3286
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D174961at2759
OrthoFinder	1	1.000	-	-		FOG0007798
OrthoInspector	1	1.000	-	-		oto46008
orthoMCL	1	0.900	-	-		OOG6_112465
Panther	1	1.100	-	-	LDO	PTHR11477
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6674
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	15	15.300