DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PHF3 and Phf3

DIOPT Version :9

Sequence 1:	XP_011533950.1	Gene:	PHF3 / 23469	HGNCID:	8921	Length:	2048	Species:	Homo sapiens
Sequence 2:	NP_001102261.1	Gene:	Phf3 / 363210	RGDID:	1304925	Length:	2020	Species:	Rattus norvegicus

Alignment Length:	2050	Identity:	1603/2050 - (78%)
Similarity:	1776/2050 - (86%)	Gaps:	41/2050 - (2%)

- Green bases have known domain annotations that are detailed below.

Human    10 MDIVDTFNHLIPTEHLDDALFLGSNLENEVCEDFSASQNVLEDSLKNMLSDKDPMLGSASNQFCL 74
            |||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||
  Rat     1 MDIVDTFNHLIPTEHLDDALFLGSNLENEVCEDFSTSQNVLEDSLKNMLSDKDPMLGSASNQFCL 65

Human    75 PVLDSNDPNFQMPCSTVVGLDDIMDEGVVKESGNDTIDEEELILPNRNLRDKVEENSVRSPRKSP 139
            ||||||||||||||:||||||||||||||||||||||||||||||||:|||:||:||||||||||
  Rat    66 PVLDSNDPNFQMPCTTVVGLDDIMDEGVVKESGNDTIDEEELILPNRSLRDRVEDNSVRSPRKSP 130

Human   140 RLMAQEQVRSLRQSTIAKRSNAAPLSNTKKASGKTVSTAKAGVKQPERSQVKEEVCMSLKPEYHK 204
            |||||||||||||||||||||||||| |||.||||.||:|||||.|||.|.||||..|||.|:.|
  Rat   131 RLMAQEQVRSLRQSTIAKRSNAAPLS-TKKPSGKTFSTSKAGVKPPERCQGKEEVYASLKSEHPK 194

Human   205 ENRRCSRNSGQIEVVPEVSVSSSHSSVSSCLEMKDEDGLDSKHKCNNPGEIDVPSHELNCSLLSE 269
            |:||.||::..:::|.|||.||:.|.|.||:.||:...|..:|.|||.||:..||.:|:||..||
  Rat   195 ESRRNSRHAEHMDMVLEVSASSADSPVPSCVGMKEAAELHPRHACNNQGEVSAPSPDLSCSPPSE 259

Human   270 TCVT--IGEKKNEALMECKAKPVGSPLFKFSDKEEHEQNDSISGKTGETVVEEMIATRKVEQDSK 332
            ...:  :|.|:.|||||||..  .|||||.|.||: ||:|.:||:..:| :|.:.|..::||:|:
  Rat   260 ASASAGVGGKRTEALMECKTS--SSPLFKVSVKED-EQSDLVSGELDDT-IEGVNAVGRLEQESE 320

Human   333 ETVKLSHEDDHILEDAGSSDISSDAACTNPNKTENSLVGLPSCVDEVTECNLELKDTMGIADKTE 397
            | :|.|.|.|.:..:..|||:|||:|||:.||||.         :|..:|:||||:|:.|.||.|
  Rat   321 E-IKFSCEGDRMSTEPESSDVSSDSACTDKNKTEK---------NEGAQCHLELKNTVDIVDKPE 375

Human   398 NTLERNKIEPLGYCEDAESN-RQLESTEFNKSNLEVVDTSTFGPESNILENAICDVPDQNSKQLN 461
            |:...|::|.|.|.||..:| .||:||||.||:||.|||..|.||::..||.|||||||||||||
  Rat   376 NSPPSNQMEMLDYGEDVGTNDAQLQSTEFTKSHLEEVDTCAFEPETSTFENTICDVPDQNSKQLN 440

Human   462 AIESTKIESHETANLQDDRNSQSSSVSYLESKSVKSKHTKPVIHSKQNMTTDAPKKIVAAKYEVI 526
            ..:|.|:   ||:||||||       |.|..|::||||||.|.|||.:||.:.|:|.||.|.||.
  Rat   441 ITQSIKM---ETSNLQDDR-------SGLGPKNMKSKHTKSVTHSKPSMTIETPRKTVAVKPEVG 495

Human   527 HSKTKVNVKSVKRNTDVPESQQNFHRPVKVRKKQIDKEPKIQSCNSGVKSVKNQAHSVLKKTLQD 591
            |||||.|.|::|||.|.||.|.:..|||||||||:||:.|.|||||||||||.|.||||||..||
  Rat   496 HSKTKSNAKTMKRNADEPEPQPDCQRPVKVRKKQVDKDLKSQSCNSGVKSVKGQVHSVLKKIPQD 560

Human   592 QTLVQIFKPLTHSLSDKSHAHPG-CLKEPHHPAQTGHVSHSSQKQCHKPQQQAPAMKTNSHVKEE 655
            ||.:||.||||||::||...|.| .|::|.||..|||:.||:|||.||||.||.|::..|||::|
  Rat   561 QTAMQISKPLTHSVNDKLPGHSGHSLEKPPHPGHTGHLVHSNQKQSHKPQPQAGAVRVTSHVRDE 625

Human   656 LEHPGVEHFKEEDKLKLKKPEKNLQPRQRRSSKSFSLDEPPLFIPDNIATIRREGSDHSSSFESK 720
            .||||.||.|||||||.||.::||||||||||:|||||||||||||||||:::||||.::|.|:|
  Rat   626 HEHPGTEHPKEEDKLKPKKLDRNLQPRQRRSSRSFSLDEPPLFIPDNIATVKKEGSDQTTSVENK 690

Human   721 YMWTPSKQCGFCKKPHGNRFMVGCGRCDDWFHGDCVGLSLSQAQQMGEEDKEYVCVKCCAEEDKK 785
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||::||||||||
  Rat   691 YMWTPSKQCGFCKKPHGNRFMVGCGRCDDWFHGDCVGLSLSQAQQMGEEDKEYVCIRCCAEEDKK 755

Human   786 TEILDPDTLENQATVEFHSGDKTMECEKL--GLSKHT-TNDRTKYIDDTVKHKVKILKRESGEGR 847
            |:|||.:|||.||::|.||.||.:||.||  ..|||: |.|:.:::||..:|||||:||:||||:
  Rat   756 TDILDTETLETQASLEAHSEDKRVECGKLTSSSSKHSVTEDKHRHMDDPGRHKVKIVKRDSGEGK 820

Human   848 NSSDCRDNEIKKWQLAPLRKMGQPVLPRRSSEEKSEKIPKESTTVTCTGEKASKPGTHEKQEMKK 912
            .|||.|||||||||||||||:|||:|||||||||||||.|:|..:||.||||::.|||||||.||
  Rat   821 TSSDSRDNEIKKWQLAPLRKLGQPLLPRRSSEEKSEKIAKDSAALTCAGEKAARSGTHEKQETKK 885

Human   913 KKVEKGVLNVH-PAASASKPSADQIRQSVRHSLKDILMKRLTDSNLKVPEEKAAKVATKIEKELF 976
            ||||||..||| |||:|.|||||||||||||||||||||||||||||:||||:||||||||||||
  Rat   886 KKVEKGGPNVHPPAAAAIKPSADQIRQSVRHSLKDILMKRLTDSNLKIPEEKSAKVATKIEKELF 950

Human   977 SFFRDTDAKYKNKYRSLMFNLKDPKNNILFKKVLKGEVTPDHLIRMSPEELASKELAAWRRRENR 1041
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   951 SFFRDTDAKYKNKYRSLMFNLKDPKNNILFKKVLKGEVTPDHLIRMSPEELASKELAAWRRRENR 1015

Human  1042 HTIEMIEKEQREVERRPITKITHKGEIEIESDAPMKEQEAAMEIQEP-AANKSLEKPEGSEKQKE 1105
            ||||||||||||||||||||||||||||||||||||||||||||||| :||||.||||.||||||
  Rat  1016 HTIEMIEKEQREVERRPITKITHKGEIEIESDAPMKEQEAAMEIQEPSSANKSSEKPEASEKQKE 1080

Human  1106 EVDSMSKDTTSQHRQHLFDLNCKICIGRMAPPVDDLSPKKVKVVVGVARKHSDNEAESIADALSS 1170
            |:||.||||||||||||||||||||||||||||||||||.||||||.||||||||||||||||||
  Rat  1081 ELDSTSKDTTSQHRQHLFDLNCKICIGRMAPPVDDLSPKTVKVVVGGARKHSDNEAESIADALSS 1145

Human  1171 TSNILASEFFEEEKQESPKSTFSPAPRPEMPGTVEVESTFLARLNFIWKGFINMPSVAKFVTKAY 1235
            |:||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||
  Rat  1146 TTNILASEFFEEEKQESPKSTFSPTPRPEMPGTVEVESTFLARLNFIWKGFINMPSVAKFVTKAY 1210

Human  1236 PVSGSPEYLTEDLPDSIQVGGRISPQTVWDYVEKIKASGTKEICVVRFTPVTEEDQISYTLLFAY 1300
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1211 PVSGSPEYLTEDLPDSIQVGGRISPQTVWDYVEKIKASGTKEICVVRFTPVTEEDQISYTLLFAY 1275

Human  1301 FSSRKRYGVAANNMKQVKDMYLIPLGATDKIPHPLVPFDGPGLELHRPNLLLGLIIRQKLKRQHS 1365
            |||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||
  Rat  1276 FSSRKRYGVAANNMKQVKDMYLIPLGAADKIPHPLVPFDGPGLELHRPNLLLGLIIRQKLKRQHS 1340

Human  1366 ACASTSHIAETPESAPPIALPPDKKSKIEVSTEEAPEEENDFFNSFTTVLHKQRNKPQQNLQEDL 1430
            |.|..||.||||||| ||:||||||.|:|.|||||.|||:|||||||||||||||||.|..||||
  Rat  1341 ASAGPSHTAETPESA-PISLPPDKKGKMESSTEEAAEEESDFFNSFTTVLHKQRNKPPQPPQEDL 1404

Human  1431 PTAVEPLMEVTKQEPPKPLRFLPGVLIGWENQPTTLELANKPLPVDDILQSLLGTTGQVYDQAQS 1495
            |||.|||||||||||||||||||||||||||||:||||||||||||||||||||||||||:|||.
  Rat  1405 PTAAEPLMEVTKQEPPKPLRFLPGVLIGWENQPSTLELANKPLPVDDILQSLLGTTGQVYEQAQP 1469

Human  1496 VMEQNTVKEIPFLNEQTNSKIEKTDNVEVTDGENKEIKVKVDNISESTDKSAEI-ETSVVGSSSI 1559
            |:||:|:|||||:|:||..|:||.|.||||:||.||||||.:|:||||.|::.: |||:||||||
  Rat  1470 VVEQSTLKEIPFINDQTTPKVEKIDKVEVTEGEAKEIKVKAENVSESTGKNSGVEETSLVGSSSI 1534

Human  1560 SAGSLTSLSLRGKPPDVSTEAFLTNLSIQSKQEETVESKEKTLKRQLQEDQENNLQDNQTSNSSP 1624
            |.|.|.||||||||||||||||||||||.||||||||:||:||||.|.:||||:.|||:|.::||
  Rat  1535 SPGPLASLSLRGKPPDVSTEAFLTNLSIPSKQEETVENKERTLKRPLLQDQENSSQDNRTCSNSP 1599

Human  1625 CRSNVGKGNIDGNVSCSENLVANTARSPQFINLKRDPRQAAGRSQPVTTSESKDGDSCRNGEKHM 1689
            ||.:.|||::|||||||||||||| ||||||||||||||||||||. |.|:||||:||||||:|.
  Rat  1600 CRPSTGKGSVDGNVSCSENLVANT-RSPQFINLKRDPRQAAGRSQQ-TVSDSKDGESCRNGERHS 1662

Human  1690 LPGLSHNKEHLTEQINVEEKLCSAEKNSCVQQSDNLKVAQNSPSVENIQTSQAEQAKPLQEDILM 1754
            :...|:|:|.: |.::.|.|..|.||:|||:|||:.:...||.||||..:||||||.|||||||.
  Rat  1663 VCAPSYNREPV-EPVSGEGKPSSLEKSSCVEQSDDSEAVPNSSSVENSNSSQAEQANPLQEDILT 1726

Human  1755 QNIETVHPFRRGSAVATSHFEVGNTCPSEFPSKSITFTSRSTSPRTSTNFSPMRPQQPNLQHLKS 1819
            |||||:||||||||.::||||.||||.||||||||.||.||||||.|||||||||||||||||||
  Rat  1727 QNIETIHPFRRGSATSSSHFEGGNTCQSEFPSKSINFTPRSTSPRASTNFSPMRPQQPNLQHLKS 1791

Human  1820 SPPGFPFPGPPNFPPQSMFGFPPHLPPPLLPPPGFGFAQN-PMVPWPPVVHLPGQPQRMMGPLSQ 1883
            ||||||||||.||||||:|||||||||||||||||||.|| ||.|||| ||:|||||||||||||
  Rat  1792 SPPGFPFPGPQNFPPQSVFGFPPHLPPPLLPPPGFGFPQNPPMAPWPP-VHVPGQPQRMMGPLSQ 1855

Human  1884 ASRYIGPQNFYQVKDIRRPERRHSDPWGRQDQQQLDRPFNRGKGDRQRFYSDSHHLKRERHEKEW 1948
            ||||:|||||||||||||||||||||||||||||.|||||||||||||||||||||||:||:|||
  Rat  1856 ASRYMGPQNFYQVKDIRRPERRHSDPWGRQDQQQPDRPFNRGKGDRQRFYSDSHHLKRDRHDKEW 1920

Human  1949 EQESERHRRRDRSQDKDRDRKSREEGHKDKERARLSHGDRGTDGKASRDSRNVDKKPDKPKSEDY 2013
            ||||||||.|||||:|||||||:||.||||||.||||.||..||||:|:|::.|||||:||.||:
  Rat  1921 EQESERHRHRDRSQEKDRDRKSKEEAHKDKERPRLSHSDRAADGKANRESKSADKKPDRPKGEDH 1985

Human  2014 EKDKEREKSKHREGEKDRDRYHKDRDHTDRTKSKR 2048
            ||:|||||||||||||||:|||||||||||.||||
  Rat  1986 EKEKEREKSKHREGEKDRERYHKDRDHTDRAKSKR 2020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PHF3	XP_011533950.1	PHD_PHF3	728..778	CDD:277108	48/49 (98%)
		TFIIS_M	934..1044	CDD:284835	107/109 (98%)
		SPOC	1218..1324	CDD:285043	105/105 (100%)
		PRP38_assoc	<1941..2035	CDD:289628	73/93 (78%)
		DUF1777	1954..>2048	CDD:285811	74/93 (80%)
Phf3	NP_001102261.1	PHD_PHF3	698..748	CDD:277108	48/49 (98%)
		TFIIS_M	908..1018	CDD:284835	107/109 (98%)
		SPOC	1193..1299	CDD:285043	105/105 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83677860
Domainoid	1	1.000	1122	1.000	Domainoid score	I1164
eggNOG	1	0.900	-	-		E1_KOG1634
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9040
Inparanoid	1	1.050	3141	1.000	Inparanoid score	I463
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG37752
OrthoDB	1	1.010	-	-		D16978at32523
OrthoFinder	1	1.000	-	-		FOG0007798
OrthoInspector	1	1.000	-	-		oto136250
orthoMCL	1	0.900	-	-		OOG6_112465
Panther	1	1.100	-	-	LDO	PTHR11477
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6674
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270