DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PHF3 and SPCC645.13

DIOPT Version :9

Sequence 1:	XP_011533950.1	Gene:	PHF3 / 23469	HGNCID:	8921	Length:	2048	Species:	Homo sapiens
Sequence 2:	NP_001342882.1	Gene:	SPCC645.13 / 2538700	PomBaseID:	SPCC645.13	Length:	721	Species:	Schizosaccharomyces pombe

Alignment Length:	787	Identity:	190/787 - (24%)
Similarity:	316/787 - (40%)	Gaps:	163/787 - (20%)

- Green bases have known domain annotations that are detailed below.

Human   742 VGCGRCDDWFHGDCVGLSLSQAQQMGEEDKE----YVCVKCCAEEDKKTEILD-PDTLENQATVE 801
            |.|..||.|.|..||||:          ||:    |.|..|.:..|..:::.: |:..|...|.:
pombe    36 VQCDGCDCWQHASCVGLA----------DKDIPESYYCEVCHSRSDVSSQVQNSPNKDEEHQTAD 90

Human   802 FHSGDKTMECEKLGLSKHTTNDRTKYIDDTVKHKVK-ILKRESGEGRNSSDCRDNE------IKK 859
            .             |:.:..|::....::.|....| .:.:|||....||:.....      .:.
pombe    91 L-------------LASNEGNEKNNEENNVVSSDSKEAITKESGAELESSEPASTNSNVGMTTRS 142

Human   860 WQLAPLRKMGQPVLPRRSSEEKSEKIPKESTTVTCTGEKASK--PGTHEKQEMKKKKVEKGVLNV 922
            .:.:|...:|. ..|:.|....|.:..:.|...|.|..|.||  |.|..|....:...::..|::
pombe   143 GRQSPRTPIGS-TTPKSSHSPPSTRKRRGSVGTTATHTKRSKNAPKTSPKDASNETADQEKELSL 206

Human   923 HPAASASKPSADQIRQSVRHSL--------KDILMKRLTDSNLKVPEEKAAKVATKIEKELF--- 976
            |       .|.|:|:..||.|:        :.|:.|...:....:.:..:..:|.::|..:|
pombe   207 H-------TSIDEIQNPVRKSVAKAWVSVFEKIIEKAKLEGVQGLEDLNSTSLALQLEHIMFMVL 264

Human   977 SFFRD----TDAKYKNKYRSLMFNLKDPKNNILFKKVLKGEVTPDHLIRMSPEELASKEL----A 1033
            |:..|    .:.||:.|:|:|.|||.|.||.....:|||.|::.:.|:.:|.||:|:.:|    .
pombe   265 SYTTDHSLTPNNKYREKFRALRFNLVDDKNPAFRARVLKNEISFNDLVNLSSEEMANPDLKNLAE 329

Human  1034 AWRRRENRHTI---EMIEKEQREVERRPITKITHKGEIEIESDAPMKEQEAAMEIQEPAANKSLE 1095
            ..|::...:|:   .:|....|.::.   .|:|.:.|:.|      .|.:.||..:.|.   .|.
pombe   330 EIRQQSTENTVIKQHLIAPRDRLLDE---DKLTQQDELGI------AENDDAMFPKPPG---ELV 382

Human  1096 KPEGSEKQKEEVDSMSKDTTSQHRQHLFDLNCKICIGRMAPPV--DDLS--PKKVKVVVGVARKH 1156
            .|....:::..:||.| .|..:|.                 |:  ||.|  .|..|      ||.
pombe   383 APISIAEEEPTIDSKS-PTLPEHN-----------------PLSEDDTSNGDKAAK------RKG 423

Human  1157 SDNEAESIADALS----STSNILASEFFEEE---KQESPKSTFSPAPRPEMPGTVEVESTFLARL 1214
            |.|:.:.|.:..|    ....||  :..|||   :.:|..|.:|||.      .:..||.|....
pombe   424 SFNDTKPIVNVPSIVEIDDPTIL--DIVEEEPLARNDSFSSPYSPAE------DMAEESEFFGMK 480

Human  1215 NFIWKGFINMPSVAKFVTKAYPVSG--SPEYLTEDLPDSIQVGGRISPQTVWDYVEKIKASGTKE 1277
            ..||.|.:.|.:|::|...|..:.|  |..:|.|.|..:..:.||||..:|..|...::.:.:||
pombe   481 EKIWTGKVKMATVSEFHANALNLFGDVSASHLFEILSATALIEGRISVSSVLQYFHALRKTPSKE 545

Human  1278 ICVVRFTPVTEEDQISYTLLFAYFSSRKRYGVAANNMKQVKDMYLIPLGATDKIPHPLVPFDGPG 1342
            |..|.|.| ||::...:.:|:.||..|.||||..:....|||.|:||:.:.:.:|..|...  |.
pombe   546 IIAVLFVP-TEQNSQGFDILYDYFVKRNRYGVLHSKSNSVKDAYIIPMPSGNSVPELLDLL--PK 607

Human  1343 LELHRP---NLLLGLIIRQKLKRQHSACASTSHIAETPESAPPIALPPDKKSKIEVSTEEAPEEE 1404
            ::|.:.   ...:||.:..|...:|          |:.|.|.||.          .||...|...
pombe   608 VDLPKDRNFQYFMGLFVLNKSSSRH----------ESVERATPIT----------TSTNGIPSTY 652

Human  1405 NDFFNSFTTVLHKQRNKPQQNLQEDLPTAVEP-----LMEVTKQEPPKPLRFLPGVLIGWENQPT 1464
            .....:.|..:|...:      .|.:..|:.|     :.:|.:..|  .:|..|.:.|..:....
pombe   653 QSASGTPTNPVHSYPS------LESIINALTPSDMLLIKDVVENNP--QIRANPSLAINPQFMQN 709

Human  1465 TLELANK 1471
            .:..|.|
pombe   710 AISAAQK 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PHF3	XP_011533950.1	PHD_PHF3	728..778	CDD:277108	14/39 (36%)
		TFIIS_M	934..1044	CDD:284835	34/128 (27%)
		SPOC	1218..1324	CDD:285043	37/107 (35%)
		PRP38_assoc	<1941..2035	CDD:289628
		DUF1777	1954..>2048	CDD:285811
SPCC645.13	NP_001342882.1	PHD_SF	22..66	CDD:328929	14/39 (36%)
		TFS2M	215..330	CDD:128786	31/114 (27%)
		SPOC	474..624	CDD:311609	48/152 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	74	1.000	Domainoid score	I2864
eggNOG	1	0.900	-	-		E1_KOG1634
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007798
OrthoInspector	1	1.000	-	-		oto146766
orthoMCL	1	0.900	-	-		OOG6_112465
Panther	1	1.100	-	-	O	PTHR11477
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.810