DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PHF3 and Phf3

DIOPT Version :9

Sequence 1:	XP_011533950.1	Gene:	PHF3 / 23469	HGNCID:	8921	Length:	2048	Species:	Homo sapiens
Sequence 2:	NP_001074549.1	Gene:	Phf3 / 213109	MGIID:	2446126	Length:	2025	Species:	Mus musculus

Alignment Length:	2052	Identity:	1602/2052 - (78%)
Similarity:	1756/2052 - (85%)	Gaps:	40/2052 - (1%)

- Green bases have known domain annotations that are detailed below.

Human    10 MDIVDTFNHLIPTEHLDDALFLGSNLENEVCEDFSASQNVLEDSLKNMLSDKDPMLGSASNQFCL 74
            |||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||
Mouse     1 MDIVDTFNHLIPTEHLDDALFLGSNLENEVCEDFSTSQNVLEDSLKNMLSDKDPMLGSASNQFCL 65

Human    75 PVLDSNDPNFQMPCSTVVGLDDIMDEGVVKESGNDTIDEEELILPNRNLRDKVEENSVRSPRKSP 139
            |||||||||||||||||||||||||||||||||||||||||||||||:|||:||:||||||||||
Mouse    66 PVLDSNDPNFQMPCSTVVGLDDIMDEGVVKESGNDTIDEEELILPNRSLRDRVEDNSVRSPRKSP 130

Human   140 RLMAQEQVRSLRQSTIAKRSNAAPLSNTKKASGKTVSTAKAGVKQPERSQVKEEVCMSLKPEYHK 204
            |||||||||||||||||||||||.|| |||.||||:||:|.|||..||.|.||||..|||.|:.|
Mouse   131 RLMAQEQVRSLRQSTIAKRSNAATLS-TKKPSGKTLSTSKVGVKPAERCQGKEEVYASLKSEHPK 194

Human   205 ENRRCSRNSGQIEVVPEVSVSSSHSSVSSCLEMKDEDGLDSKHKCNNPGEIDVPSHELNCSLLSE 269
            |:||..|::.|::|.||||.||..||||||..||:|...|.||.|||.||::|||.||:|.||||
Mouse   195 ESRRSGRHAEQMDVAPEVSASSVDSSVSSCAGMKEEAEFDPKHACNNQGEVNVPSPELDCPLLSE 259

Human   270 TCVTIGEKKNEALMECKAKPVGSPLFKFSDKEEHEQNDSISGKTGETVVEEMIATRKVEQDSKET 334
            |..::.||..|||||||||...||||||..:|: ||:|.:||:..:| :|...|..|.:|:|:|
Mouse   260 TSASVEEKNIEALMECKAKTNSSPLFKFPVRED-EQSDLVSGELNDT-IEGKDAGGKPDQESEE- 321

Human   335 VKLSHEDDHILEDAGSSDISSDAACTNPNKTENSLVGLPSCVDEVTECNLELKDTMGIADKTENT 399
            ||...|.|...|:..|||:|||:||.|.||.|.         :|..||:||||:|:.|.||.||:
Mouse   322 VKFPCEGDQTAEEPESSDVSSDSACANKNKAEK---------NEGAECHLELKNTVDIVDKPENS 377

Human   400 LERNKIEPLGYCEDAESN-RQLESTEFNKSNLEVVDTSTFGPESNILENAICDVPDQNSKQLNAI 463
            .:||::|.|||.||.||| .:|:|||||||:||.||...|.||::.|||.||||.||||||||..
Mouse   378 PQRNELETLGYGEDTESNDARLQSTEFNKSDLEEVDACAFEPEASTLENTICDVLDQNSKQLNIT 442

Human   464 ESTKIESHETANLQDDRNSQSSSVSYLESKSVKSKHTKPVIHSKQNMTTDAPKKIVAAKYEVIHS 528
            :|.|:   |||||||||       |.||.|::|.||.|.|.||||:|||:.|:|.||||:||.||
Mouse   443 QSIKM---ETANLQDDR-------SGLEPKNIKPKHIKSVTHSKQSMTTETPRKTVAAKHEVGHS 497

Human   529 KTKVNVKSVKRNTDVPESQQNFHRPVKVRKKQIDKEPKIQSCNSGVKSVKNQAHSVLKKTLQDQT 593
            |||.|||:||||:..||.|.:..|||||||||.||..|.|||||||||||:|||||||:..|||.
Mouse   498 KTKSNVKAVKRNSGEPEPQPDSQRPVKVRKKQGDKVWKSQSCNSGVKSVKSQAHSVLKRMPQDQN 562

Human   594 LVQIFKPLTHSLSDKSHAHPGCLKEPHHPAQTGHVSHSSQKQCHKPQQQAPAMKTNSHVKEELEH 658
            .:||.|||||..|||.|.|.|..|||.||.||||:.||||||..||||||...|.:||||:|.:|
Mouse   563 TMQISKPLTHPHSDKLHGHSGFSKEPPHPVQTGHLVHSSQKQSQKPQQQAAVGKGSSHVKDEHDH 627

Human   659 PGVEHFKEEDKLKLKKPEKNLQPRQRRSSKSFSLDEPPLFIPDNIATIRREGSDHSSSFESKYMW 723
            |..||.||:||||.:||::||||||||||:|||||||||||||||||:::||||.::|.||||||
Mouse   628 PVSEHLKEDDKLKPRKPDRNLQPRQRRSSRSFSLDEPPLFIPDNIATVKKEGSDQTTSIESKYMW 692

Human   724 TPSKQCGFCKKPHGNRFMVGCGRCDDWFHGDCVGLSLSQAQQMGEEDKEYVCVKCCAEEDKKTEI 788
            |||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||:|
Mouse   693 TPSKQCGFCKKPHGNRFMVGCGRCDDWFHGDCVGLSLSQAQQMGEEDKEYVCVRCCAEEDKKTDI 757

Human   789 LDPDTLENQATVEFHSGDKTMECEKLGLSKH-TTNDRTKYIDDTVKHKVKILKRESGEGRNSSDC 852
            ||.:..|.||.:|.||.||.|||.||..||| .|:|:.::.||..||||||||||||||:.|||.
Mouse   758 LDTEIFEAQAPIEAHSEDKRMECGKLTSSKHAVTDDKHRHSDDPGKHKVKILKRESGEGKTSSDS 822

Human   853 RDNEIKKWQLAPLRKMGQPVLPRRSSEEKSEKIPKESTTVTCTGEKASKPGTHEKQEMKKKKVEK 917
            |||||||||||||||:.||.|||||||||||||.||||.:..|||:.::.|||||||.||||:||
Mouse   823 RDNEIKKWQLAPLRKLSQPHLPRRSSEEKSEKIAKESTALASTGERVARSGTHEKQETKKKKMEK 887

Human   918 GVLNVHPAASASKPSADQIRQSVRHSLKDILMKRLTDSNLKVPEEKAAKVATKIEKELFSFFRDT 982
            |..||||.|:.||||||||||||||||||||||||||||||:|||||||||||||||||||||||
Mouse   888 GGPNVHPPAATSKPSADQIRQSVRHSLKDILMKRLTDSNLKIPEEKAAKVATKIEKELFSFFRDT 952

Human   983 DAKYKNKYRSLMFNLKDPKNNILFKKVLKGEVTPDHLIRMSPEELASKELAAWRRRENRHTIEMI 1047
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   953 DAKYKNKYRSLMFNLKDPKNNILFKKVLKGEVTPDHLIRMSPEELASKELAAWRRRENRHTIEMI 1017

Human  1048 EKEQREVERRPITKITHKGEIEIESDAPMKEQEAAMEIQEPAANKSLEKPEGSEKQKEEVDSMSK 1112
            |||||||||||||||||||||||||||||||||||:|||||:||||:|||:.||||||||||.||
Mouse  1018 EKEQREVERRPITKITHKGEIEIESDAPMKEQEAAIEIQEPSANKSMEKPDVSEKQKEEVDSTSK 1082

Human  1113 DTTSQHRQHLFDLNCKICIGRMAPPVDDLSPKKVKVVVGVARKHSDNEAESIADALSSTSNILAS 1177
            |||||||||||||||||||||||||:||||||.||||||.|||||||||||:|||||||:|||.|
Mouse  1083 DTTSQHRQHLFDLNCKICIGRMAPPIDDLSPKTVKVVVGGARKHSDNEAESLADALSSTTNILTS 1147

Human  1178 EFFEEEKQESPKSTFSPAPRPEMPGTVEVESTFLARLNFIWKGFINMPSVAKFVTKAYPVSGSPE 1242
            :.|||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1148 DLFEEEKQESPKSTFSPTPRPEMPGTVEVESTFLARLNFIWKGFINMPSVAKFVTKAYPVSGSPE 1212

Human  1243 YLTEDLPDSIQVGGRISPQTVWDYVEKIKASGTKEICVVRFTPVTEEDQISYTLLFAYFSSRKRY 1307
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1213 YLTEDLPDSIQVGGRISPQTVWDYVEKIKASGTKEICVVRFTPVTEEDQISYTLLFAYFSSRKRY 1277

Human  1308 GVAANNMKQVKDMYLIPLGATDKIPHPLVPFDGPGLELHRPNLLLGLIIRQKLKRQHSACASTSH 1372
            ||||||||||||||||||||.||||||||||||||||||||||||||||||||||.|||.|..||
Mouse  1278 GVAANNMKQVKDMYLIPLGAADKIPHPLVPFDGPGLELHRPNLLLGLIIRQKLKRPHSASAGPSH 1342

Human  1373 IAETPESAPPIALPPDKKSKIEVSTEEAPEEENDFFNSFTTVLHKQRNKPQQNLQEDLPTAVEPL 1437
            ..|||||| ||.||||||.|:|..||||.|||:|||||||||||||||||.|.||||||||.|||
Mouse  1343 TGETPESA-PIVLPPDKKGKMESCTEEAAEEESDFFNSFTTVLHKQRNKPSQPLQEDLPTAAEPL 1406

Human  1438 MEVTKQEPPKPLRFLPGVLIGWENQPTTLELANKPLPVDDILQSLLGTTGQVYDQAQSVMEQNTV 1502
            ||||||||||||||||||||||:|||:||||||||||||||||||||||||||:|||.::||:|:
Mouse  1407 MEVTKQEPPKPLRFLPGVLIGWDNQPSTLELANKPLPVDDILQSLLGTTGQVYEQAQPLVEQSTL 1471

Human  1503 KEIPFLNEQTNSKIEKTDNVEVTDGENKEIKVKVDNISESTDKSAEIETSVVGSSSISAGSLTSL 1567
            |||||:|:|.|.|:||.|.||||:|:.||||||.:|||.||.|::..|||.|||||||.|.|.||
Mouse  1472 KEIPFINDQANPKVEKIDKVEVTEGDAKEIKVKAENISVSTSKNSGEETSSVGSSSISPGPLASL 1536

Human  1568 SLRGKPPDVSTEAFLTNLSIQSKQEETVESKEKTLKRQLQEDQENNLQDNQTSNSSPCRSNVGKG 1632
            ||||||||||||||||||||.|||||:||:||:||||.|.:||||:||||:||:.|||....|||
Mouse  1537 SLRGKPPDVSTEAFLTNLSIPSKQEESVENKERTLKRLLLQDQENSLQDNRTSSDSPCWPGTGKG 1601

Human  1633 NID--------GNVSCSENLVANTARSPQFINLKRDPRQAAGRSQPVTTSESKDGDSCRNGEKHM 1689
            .:|        |:.|.||..|||| |:||||||||||||||||||. |.|||||.:|||||:||.
Mouse  1602 GMDGDGSGSGSGSGSGSEGPVANT-RAPQFINLKRDPRQAAGRSQQ-TASESKDAESCRNGDKHA 1664

Human  1690 LPGLSHNKEHLTEQINVEEKLCSAEKNSCVQQSDNLKVAQNSPSVENIQTSQAEQAKPLQEDILM 1754
            .....||||.|.|.:..|.||.|.||:|||:|:|:.:.|.||.||||:.:||||||.|.|||:|.
Mouse  1665 ASAPPHNKEPLAEAVGGEGKLPSQEKSSCVEQNDDSEAAPNSSSVENLNSSQAEQANPSQEDVLT 1729

Human  1755 QNIETVHPFRRGSAVATSHFEVGNTCPSEFPSKSITFTSRSTSPRTSTNFSPMRPQQPNLQHLKS 1819
            ||||||||||||||..:|.||.||||.|||||||::||.||:|||.|||||||||||||||||||
Mouse  1730 QNIETVHPFRRGSAPTSSRFEGGNTCQSEFPSKSVSFTCRSSSPRASTNFSPMRPQQPNLQHLKS 1794

Human  1820 SPPGFPFPGPPNFPPQSMFGFPPHLPPPLLPPPGFGFAQN-PMVPWPPVVHLPGQPQRMMGPLSQ 1883
            ||||||||||.|||||:||||||||.|||||||||||.|| ||||||| ||:|||||||||||||
Mouse  1795 SPPGFPFPGPQNFPPQNMFGFPPHLSPPLLPPPGFGFPQNPPMVPWPP-VHVPGQPQRMMGPLSQ 1858

Human  1884 ASRYIGPQNFYQVKDIRRPERRHSDPWGRQDQQQLDRPFNRGKGDRQRFYSDSHHLKRERHEKEW 1948
            ||||:|||||||||||||||||||||||||||||.||||||||||||||||||||||||||:|:|
Mouse  1859 ASRYMGPQNFYQVKDIRRPERRHSDPWGRQDQQQPDRPFNRGKGDRQRFYSDSHHLKRERHDKDW 1923

Human  1949 EQESERHRRRDRSQDKDRDRKSREE--GHKDKERARLSHGDRGTDGKASRDSRNVDKKPDKPKSE 2011
            ||||||||.|||||::||||||:||  .||||||.|||||||..|||||||.::.|||||:||.|
Mouse  1924 EQESERHRHRDRSQERDRDRKSKEEAAAHKDKERPRLSHGDRAPDGKASRDGKSADKKPDRPKGE 1988

Human  2012 DYEKDKEREKSKHREGEKDRDRYHKDRDHTDRTKSKR 2048
            |:||:|||:||||:||||||:|||||||||||.||||
Mouse  1989 DHEKEKERDKSKHKEGEKDRERYHKDRDHTDRVKSKR 2025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PHF3	XP_011533950.1	PHD_PHF3	728..778	CDD:277108	49/49 (100%)
		TFIIS_M	934..1044	CDD:284835	108/109 (99%)
		SPOC	1218..1324	CDD:285043	105/105 (100%)
		PRP38_assoc	<1941..2035	CDD:289628	72/95 (76%)
		DUF1777	1954..>2048	CDD:285811	73/95 (77%)
Phf3	NP_001074549.1	PHD_PHF3	697..747	CDD:277108	49/49 (100%)
		TFIIS_M	904..1017	CDD:369395	111/112 (99%)
		PHA03369	<983..1184	CDD:223061	185/200 (93%)
		SPOC	1181..1327	CDD:369497	144/145 (99%)
		SF-CC1	1916..>2025	CDD:273721	84/108 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83952405
Domainoid	1	1.000	1086	1.000	Domainoid score	I1375
eggNOG	1	0.900	-	-		E1_KOG1634
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9040
Inparanoid	1	1.050	3144	1.000	Inparanoid score	I543
Isobase	1	0.950	-	0	Normalized mean entropy	S6592
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG37752
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007798
OrthoInspector	1	1.000	-	-		oto119959
orthoMCL	1	0.900	-	-		OOG6_112465
Panther	1	1.100	-	-	LDO	PTHR11477
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6674
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	17.210