Protein Alignment CBX5 and Su(var)205

DIOPT Version :10

• Sequence 1: NP_036249.1
• Gene: CBX5 / 23468
• HGNCID: 1555
• Length: 191
• Species: Homo sapiens
• Sequence 2: NP_476755.1
• Gene: Su(var)205 / 34119
• FlyBaseID: FBgn0003607
• Length: 206
• Species: Drosophila melanogaster
• Alignment Length: 206
• Identity: 88/206 - (42%)
• Similarity: 121/206 - (58%)
• Gaps: 26/206 - (12%)

Human     1 MGKKTKRTADSS----SSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDCPE 61
            ||||......|:    :.|:||||.|||::||||.||:|||.|||||:.|..||||||.||||.:
  Fly     1 MGKKIDNPESSAKVSDAEEEEEEYAVEKIIDRRVRKGKVEYYLKWKGYPETENTWEPENNLDCQD 65

Human    62 LISEFMKKYK-----------------KMKEGENNKPREKSESNKRKSNFSNSADDIKSKKKREQ 109
            ||.::....|                 |.||.:.......|.::||||....:....|||:..:.
  Fly    66 LIQQYEASRKDEEKSAASKKDRPSSSAKAKETQGRASSSTSTASKRKSEEPTAPSGNKSKRTTDA 130

Human   110 SNDI-----ARGFERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYE 169
            ..|.     :.||:||||.|||:||:|:.|.|.||:::|..|:|::|.:..||.|.|::||.|||
  Fly   131 EQDTIPVSGSTGFDRGLEAEKILGASDNNGRLTFLIQFKGVDQAEMVPSSVANEKIPRMVIHFYE 195

Human   170 ERLTWHAYPED 180
            |||:|::..||
  Fly   196 ERLSWYSDNED 206

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CBX5	NP_036249.1	CD_HP1alpha_Cbx5	19..68	CDD:349298	32/48 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	70..117		13/68 (19%)
		CSD_HP1alpha_Cbx5	116..173	CDD:349302	31/56 (55%)
Su(var)205	NP_476755.1	CD_HP1a_insect	24..72	CDD:349300	31/47 (66%)
		CSD_HP1a_insect	146..198	CDD:349305	27/51 (53%)