DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CBX5 and chp2

DIOPT Version :9

Sequence 1:	NP_001120793.1	Gene:	CBX5 / 23468	HGNCID:	1555	Length:	191	Species:	Homo sapiens
Sequence 2:	NP_596808.1	Gene:	chp2 / 2540047	PomBaseID:	SPBC16C6.10	Length:	380	Species:	Schizosaccharomyces pombe

Alignment Length:	224	Identity:	57/224 - (25%)
Similarity:	91/224 - (40%)	Gaps:	72/224 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    11 SSSSED---EEEYVVEKVLDRRVVK--GQVEYLLKWKGFSE-EHNTWEPEKN-LDCPELISEFMK 68
            ||.|||   :||:.||.:||.|:.|  ...:|.|||:|:.: ..|||..|:: ..|.|||..:.
pombe   164 SSGSEDKNSDEEFAVEMILDSRMKKDGSGFQYYLKWEGYDDPSDNTWNDEEDCAGCLELIDAYW- 227

Human    69 KYKKMKEGENNKP---------REKSESNK-----RKSNFSNSADDIKSKKKREQS--------- 110
                  |....||         |.::.|:.     .|...|||.|.|..|::|.::
pombe   228 ------ESRGGKPDLSSLIRLTRSRARSSNEASYVEKDESSNSDDSISYKRRRSRNAANRITDYV 286

Human   111 -NDIARGF--ERGLEPEKIIGATDS------------------C---------GDLMFLMKWKD- 144
             :|::...  |:..:.||.:.:..|                  |         |.|:..:|||:
pombe   287 DSDLSESSMKEKQSKIEKYMKSDKSSKNFKPPFQKKSWEDLVDCVKTVQQLDNGKLIAKIKWKNG 351

Human   145 -TDEADLVLAKEANVKCPQIVIAFYEERL 172
             ....|.::..:   |||..:|.:||..:
pombe   352 YVSTHDNIIIHQ---KCPLKIIEYYEAHI 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CBX5	NP_001120793.1	CD_HP1alpha_Cbx5	19..68	CDD:349298	20/52 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	70..117		14/70 (20%)
		CSD_HP1alpha_Cbx5	116..173	CDD:349302	17/88 (19%)
chp2	NP_596808.1	CHROMO	174..228	CDD:237991	21/60 (35%)
chp2	NP_596808.1	ChSh	316..380	CDD:197638	13/65 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	48	1.000	Domainoid score	I3903
eggNOG	1	0.900	-	-		E1_KOG1911
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22812
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.870