Protein Alignment HEY1 and cwo

DIOPT Version :9

• Sequence 1: NP_001035798.1
• Gene: HEY1 / 23462
• HGNCID: 4880
• Length: 308
• Species: Homo sapiens
• Sequence 2: NP_524775.1
• Gene: cwo / 44669
• FlyBaseID: FBgn0259938
• Length: 698
• Species: Drosophila melanogaster
• Alignment Length: 406
• Identity: 89/406 - (21%)
• Similarity: 140/406 - (34%)
• Gaps: 146/406 - (35%)

Human     4 AHP-EYSS----------SDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGII 57
            ||| :|.|          ::|.|:.:......|.|:   ...|.|..:.|:....|:.:    ||
  Fly    13 AHPVKYESEAAVSSFPYCTESSLNFSTSATAYSEDD---AEYATGRRNKTSRQDPLSHR----II 70

Human    58 EKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHAL 122
            |||||||:|:.|::|.||:|..:::    :|..::||.||::|.:.|||.|.:       :....
  Fly    71 EKRRRDRMNSCLADLSRLIPPQYQR----KGRGRIEKTEIIEMAIRHLKHLQS-------ECQQK 124

Human   123 AMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNN------YASQR--------EAAS 173
            ..|||| |:.:|:.|.|::|..:...|....|..||..|::.      |.|.|        .|:|
  Fly   125 ESDYRS-GYMDCMKEAAKFLYDVHMQDFCHRLLGRLQEHIDEMFKTDCYKSTRSCHMPDNVSASS 188

Human   174 GA-HAGLGHIPWGTVFGHHPHIAH----------------------------------------- 196
            |: |.           .:||.:.|
  Fly   189 GSPHQ-----------AYHPPLCHLRDMLATSASDVEHSQDHNDVKDLSFRNHLNQLQRSQQAAA 242

Human   197 ---------------------------PLLLPQNGHGNAGT-TASPTEPHHQGRLGSA------- 226
                                       ||   .||.|..|. .|:...|.:....|||
  Fly   243 AAAVAAAAVAVANGSSPASNAGVDSKVPL---TNGGGTGGAPPAADNVPSNSTGSGSAAACAGGN 304

Human   227 --------HPEAPALRAPPSGSLGP--VLPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPN 281
                    ...|.:...||:|...|  |.|:.........|:::|.|.......:..|.|... :
  Fly   305 SNSSGSNSSNAASSTICPPAGGSCPAKVTPLAAHQQPHQAPVITSTAPHHHHHHTDSSHHDFE-S 368

Human   282 ALSPSAPTQAANLGKP 297
            :..|...|..:|:..|
  Fly   369 SREPILHTDTSNMHSP 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HEY1	NP_001035798.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52		13/58 (22%)
		bHLH_SF	41..126	CDD:381792	27/84 (32%)
		ORANGE	124..170	CDD:128787	17/59 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	200..238		11/53 (21%)
		YRPW motif	298..301		89/406 (22%)
cwo	NP_524775.1	HLH	66..118	CDD:306515	24/59 (41%)
		ORANGE	126..168	CDD:128787	14/42 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140965
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840