DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HEY1 and E(spl)m8-HLH

DIOPT Version :9

Sequence 1:	NP_001035798.1	Gene:	HEY1 / 23462	HGNCID:	4880	Length:	308	Species:	Homo sapiens
Sequence 2:	NP_524513.1	Gene:	E(spl)m8-HLH / 43161	FlyBaseID:	FBgn0000591	Length:	179	Species:	Drosophila melanogaster

Alignment Length:	177	Identity:	45/177 - (25%)
Similarity:	78/177 - (44%)	Gaps:	21/177 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    39 MSPTTSSQILARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVD 103
            |..||.:||. :|.::.::|::||.|:|..|..|:.||.....    :.|..:::|||:|:..|.
  Fly     1 MEYTTKTQIY-QKVKKPMLERQRRARMNKCLDNLKTLVAELRG----DDGILRMDKAEMLESAVI 60

Human   104 HLKMLHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHL----NN 164
            .::...|. .|...:..:|.:|....|:...:.||:|.::...|:  |..|...:::||    .|
  Fly    61 FMRQQKTP-KKVAQEEQSLPLDSFKNGYMNAVNEVSRVMASTPGM--SVDLGKSVMTHLGRVYKN 122

Human   165 YASQREAASGAH--------AGLGHIPWGTV-FGHHPHIAHPLLLPQ 202
            .....||.|.|.        :.:...|.... .|:|.....|...||
  Fly   123 LQQFHEAQSAADFIQNSMDCSSMDKAPLSPASSGYHSDCDSPAPSPQ 169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HEY1	NP_001035798.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		5/12 (42%)
		bHLH_SF	41..126	CDD:381792	23/84 (27%)
		ORANGE	124..170	CDD:128787	11/49 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..238		2/3 (67%)
		YRPW motif	298..301
E(spl)m8-HLH	NP_524513.1	HLH	10..67	CDD:238036	16/61 (26%)
E(spl)m8-HLH	NP_524513.1	ORANGE	81..125	CDD:128787	11/45 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140880
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740