Protein Alignment HEY1 and E(spl)m7-HLH

DIOPT Version :10

• Sequence 1: NP_001035798.1
• Gene: HEY1 / 23462
• HGNCID: 4880
• Length: 308
• Species: Homo sapiens
• Sequence 2: NP_536753.1
• Gene: E(spl)m7-HLH / 43160
• FlyBaseID: FBgn0002633
• Length: 186
• Species: Drosophila melanogaster
• Alignment Length: 252
• Identity: 61/252 - (24%)
• Similarity: 99/252 - (39%)
• Gaps: 79/252 - (31%)

Human    50 RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLHTAGGK 114
            ||..:.::|::||.|||..|.||:.|:...    |.:.|.||.|||:||::||.||:.|..:  |
  Fly    14 RKVMKPLLERKRRARINKCLDELKDLMAEC----VAQTGDAKFEKADILEVTVQHLRKLKES--K 72

Human   115 GYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGL 179
            .:..|:. ...:|: |:.....||:|.|:.:..:|.:  ....|::||....:|.|
  Fly    73 KHVPANP-EQSFRA-GYIRAANEVSRALASLPRVDVA--FGTTLMTHLGMRLNQLE--------- 124

Human   180 GHIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGSLGPV 244
                            .|:..||                             |:..|
  Fly   125 ----------------QPMEQPQ-----------------------------AVNTP-------- 136

Human   245 LPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRPW 301
            |.:|..:|..|....|:.:..|..|.|.| :...:.:.|..|:|      |:.:|||
  Fly   137 LSIVCGSSSSSSTYSSASSCSSISPVSSG-YASDNESLLQISSP------GQVWRPW 186

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HEY1	NP_001035798.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52		1/1 (100%)
		bHLH_SF	41..126	CDD:469605	28/75 (37%)
		ORANGE	124..170	CDD:128787	11/45 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	200..238		4/37 (11%)
		YRPW motif	298..301		1/2 (50%)
E(spl)m7-HLH	NP_536753.1	bHLH-O_ESMB_like	7..73	CDD:381584	26/64 (41%)
		ORANGE	81..125	CDD:128787	12/71 (17%)