Protein Alignment HEY1 and E(spl)m3-HLH

DIOPT Version :10

• Sequence 1: NP_001035798.1
• Gene: HEY1 / 23462
• HGNCID: 4880
• Length: 308
• Species: Homo sapiens
• Sequence 2: NP_524509.2
• Gene: E(spl)m3-HLH / 43156
• FlyBaseID: FBgn0002609
• Length: 224
• Species: Drosophila melanogaster
• Alignment Length: 287
• Identity: 62/287 - (21%)
• Similarity: 99/287 - (34%)
• Gaps: 109/287 - (37%)

Human    50 RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLHTAGGK 114
            ||..:.::|::||.|||..|.:|:.|:....:::  .:...:||||:||::||||::.|...||
  Fly    12 RKVMKPLLERKRRARINKCLDDLKDLMVECLQQE--GEHVTRLEKADILELTVDHMRKLKQRGG- 73

Human   115 GYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGL 179
                                       ||:                            .|..||:
  Fly    74 ---------------------------LSL----------------------------QGVVAGV 83

Human   180 GHIPWGTVFGH-------HPHIAHPL---LLPQNGHGNAGTTAS----------PTEPHHQGRLG 224
            |..|..|...|       :.|.|..:   ||........|....          .|:...|.:..
  Fly    84 GSPPTSTSTAHVESFRSGYVHAADQITQVLLQTQQTDEIGRKIMKFLSTRLIELQTQLLQQQQQQ 148

Human   225 SAHPEAPALRAPPSGSLGPVLPVVTSASKLSPPLLSSVA-SLSAFPFSFGSFHLLSP-------- 280
            ..|.:.               .:..|:.:|:.|||.... :.:|...|:.|| |.|.
  Fly   149 QQHQQQ---------------QIPQSSGRLAFPLLGGYGPAAAAAAISYSSF-LTSKDELIDVTS 197

Human   281 ---NALSPSA--PTQAANLGKP-YRPW 301
               ||||.:|  .:|.:...:| :|||
  Fly   198 VDGNALSETASVSSQESGASEPVWRPW 224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HEY1	NP_001035798.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52		1/1 (100%)
		bHLH_SF	41..126	CDD:469605	24/75 (32%)
		ORANGE	124..170	CDD:128787	2/45 (4%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	200..238		5/47 (11%)
		YRPW motif	298..301		1/2 (50%)
E(spl)m3-HLH	NP_524509.2	bHLH-O_ESMB_like	5..71	CDD:381584	22/60 (37%)
		ORANGE	96..136	CDD:128787	5/39 (13%)