DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HEY1 and h

DIOPT Version :9

Sequence 1:	NP_001035798.1	Gene:	HEY1 / 23462	HGNCID:	4880	Length:	308	Species:	Homo sapiens
Sequence 2:	NP_001014577.1	Gene:	h / 38995	FlyBaseID:	FBgn0001168	Length:	337	Species:	Drosophila melanogaster

Alignment Length:	370	Identity:	84/370 - (22%)
Similarity:	130/370 - (35%)	Gaps:	140/370 - (37%)

- Green bases have known domain annotations that are detailed below.

Human    31 NLSSALGSM--------SPTTSSQILARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQVMEQ 87
            |:::.||:.        :|..|.    |:..:.|:|||||.||||.|:||:.|:..|.:|.....
  Fly     9 NMTNVLGTAVVPAQLKETPLKSD----RRSNKPIMEKRRRARINNCLNELKTLILDATKKDPARH 69

Human    88 GSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASD 152
              :|||||:||:.||.||:.|..........|....::....||.:|:.||:|:    .|::.:.
  Fly    70 --SKLEKADILEKTVKHLQELQRQQAAMQQAADPKIVNKFKAGFADCVNEVSRF----PGIEPAQ 128

Human   153 PLRVRLVSHLNN---------YASQREAASGAHAGLGHIPWGTVFGHHPHIAHPLLLPQNGHGNA 208
              |.||:.||:|         :..||:                   ......|..:||
  Fly   129 --RRRLLQHLSNCINGVKTELHQQQRQ-------------------QQQQSIHAQMLP------- 165

Human   209 GTTASPTEPHHQGRLGSAHP-------EAPALRAP----------PSGSLGPVLP---------- 246
               :.|:.|....:.|:|.|       .|.....|          |:||:..|||
  Fly   166 ---SPPSSPEQDSQQGAAAPYLFGIQQTASGYFLPNGMQVIPTKLPNGSIALVLPQSLPQQQQQQ 227

Human   247 -----------------VVTSASKLSPPLLS--------------SVASLSAFPFSFGSFHLLSP 280
                             ...:|::..|.|:|              |.|...:.|.|..|.....|
  Fly   228 LLQHQQQQQQLAVAAAAAAAAAAQQQPMLVSMPQRTASTGSASSHSSAGYESAPGSSSSCSYAPP 292

Human   281 NA---------LSPS----APTQAANLG-----------KPYRPW 301
            :.         :.||    .|.:...|.           :|:|||
  Fly   293 SPANSSYEPMDIKPSVIQRVPMEQQPLSLVIKKQIKEEEQPWRPW 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HEY1	NP_001035798.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		6/28 (21%)
		bHLH_SF	41..126	CDD:381792	32/84 (38%)
		ORANGE	124..170	CDD:128787	14/54 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..238		9/54 (17%)
		YRPW motif	298..301		1/2 (50%)
h	NP_001014577.1	HLH	29..88	CDD:238036	29/64 (45%)
h	NP_001014577.1	ORANGE	106..141	CDD:128787	13/40 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810